The newfound relationship between extrachromosomal DNAs and excised signal circles
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Sum Rate Analysis of MU-MIMO with a 3D MIMO Base Station Exploiting Elevation Features
Although the three-dimensional (3D) channel model considering the elevation factor has been used to analyze the performance of multiuser multiple-input multiple-output (MU-MIMO) systems, less attention is paid to the effect of the elevation variation. In
Xingwang Li +4 more
doaj +1 more source
Possibility and purpose of using metallic conductors in double base propellants
Based on preliminary developed treatment of obtaining blocks of double base propellants, examinations of internal-ballistics and mechanical characteristics of propellants with and without metallic conductors of wire configuration have been performed ...
Panto Maslak +2 more
doaj +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Progressivity of personal income tax in Croatia: decomposition of tax base and rate effects [PDF]
This paper presents progressivity breakdowns for Croatian personal income tax (henceforth PIT) in 1997 and 2004. The decompositions reveal how the elements of the system – tax schedule, allowances, deductions and credits – contribute to the achievement ...
Ivica Urban
doaj
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Considerations regarding the influence of the base leading rate over actualization rate of investment projects financed by EU funds [PDF]
The investment process is a complex economic process that implies risks. Allotting capital resources in an investment project without using an adequate discount rate of the cash flows, which will take into account the evolution of the base leading rate ...
Attila TAMAS SZORA, Iulian DOBRA
core
On minor-closed classes of matroids with exponential growth rate [PDF]
Let $\cM$ be a minor-closed class of matroids that does not contain arbitrarily long lines. The growth rate function, $h:\bN\rightarrow \bN$ of $\cM$ is given by $$h(n) = \max(|M|\, : \, M\in \cM, simple, rank-$n$).$$ The Growth Rate Theorem shows that ...
Geelen, Jim, Nelson, Peter
core

