Results 91 to 100 of about 3,508,819 (309)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

open access: yesMolecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi   +6 more
wiley   +1 more source

Concentração de micronutrientes em mudas de maracujazeiro-doce propagado por sementes em função da calagem Concentration of micronutrients in sweet passion fruit seedlings as a function of liming

open access: yesCiência e Agrotecnologia, 2005
Conduziu-se este experimento em casa-de-vegetação visando avaliar a concentração de micronutrientes pelo maracujazeiro-doce (Passiflora alata Curtis) propagado por sementes em função da calagem.
Elda Bonilha Assis Fonseca   +3 more
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

open access: yesMolecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee   +3 more
wiley   +1 more source

Experiences with liming in European countries - results of long-term experiments

open access: yesJournal of Forest Science, 2006
Liming was and still is carried out in many European forests since the beginning of the 1980s. Main objectives of compensation liming is to neutralize actual acidic deposition in order to prevent further soil acidification, to increase base saturation ...
W. Schaaf, R. F. Hüttl
doaj   +1 more source

Marathon adaptation to spatial contrast: Saturation in sight [PDF]

open access: yes, 1985
The contrast thresholds for detecting a 6.0 c/deg vertical sinusoidal test grating were tracked during and after 3 hr inspection of a high-contrast adapting grating of the same spatial frequency and orientation.
Magnussen, S., Greenlee, Mark W.
core   +1 more source

Soil pH and base saturation in 2018.

open access: yes, 2023
The forests of central Europe have undergone remarkable transitions in the past 40 years as air quality has improved dramatically. Retrospective analysis of Norway spruce (Picea abies) tree rings in the Czech Republic shows that air pollution (e.g.
Michal Rybníček (542996)   +6 more
core   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

open access: yesFEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake   +4 more
wiley   +1 more source

Scaling Type-Based Points-to Analysis with Saturation

open access: yesProceedings of the ACM on Programming Languages
Designing a whole-program static analysis requires trade-offs between precision and scalability. While a context-insensitive points-to analysis is often considered a good compromise, it still has non-linear complexity that leads to scalability problems when analyzing large applications.
Christian Wimmer   +3 more
openaire   +3 more sources

Plane Cremona maps: Saturation and regularity of the base ideal [PDF]

open access: yes, 2012
One studies plane Cremona maps by focusing on the ideal theoretic and homological properties of its homogeneous base ideal (“indeterminacy locus”). The leitmotiv driving a good deal of the work is the relation between the base ideal and its saturation ...
Hassanzadeh, Seyed Hamid, Simis, Aron
core   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

open access: yesFEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia   +3 more
wiley   +1 more source

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