Results 91 to 100 of about 31,885,483 (388)

RY-Coding and Non-Homogeneous Models Can Ameliorate the Maximum-Likelihood Inferences from Nucleotide Sequence Data with Parallel Compositional Heterogeneity

open access: yesEvolutionary Bioinformatics, 2012
In phylogenetic analyses of nucleotide sequences, ‘homogeneous’ substitution models, which assume the stationarity of base composition across a tree, are widely used, albeit individual sequences may bear distinctive base frequencies.
Sohta A. Ishikawa   +2 more
doaj   +1 more source

Sequence-specific double-strand cleavage of DNA by penta-N-methylpyrrolecarboxamide-EDTA·Fe(II) [PDF]

open access: yes, 1983
In the presence of O2 and 5 mM dithiothreitol, penta-N-methylpyrrolecarboxamide-EDTA·Fe(II) [P5E·Fe(II)] at 0.5 µ M cleaves pBR322 plasmid DNA (50 µ M in base pairs) on opposite strands to afford discrete DNA fragments as analyzed by agarose gel ...
Dervan, Peter B., Schultz, Peter G.
core  

On the last nonzero digits of $n!$ in a given base

open access: yes, 2018
In this paper we study the sequence of strings of $k$ last nonzero digits of $n!$ in a given base $b$. We determine for which $b$ this sequence is automatic and show how to generate it using a uniform morphism.
Sobolewski, Bartosz
core   +1 more source

Insights into the renal pathophysiology in Hermansky‐Pudlak syndrome‐1 from urinary extracellular vesicle proteomics and a new mouse model

open access: yesFEBS Letters, EarlyView.
Hermansky‐Pudlak syndrome type 1 (HPS‐1) is a rare, autosomal recessive disorder with poorly understood renal involvement. Urinary extracellular vesicle (uEV) proteomics and a novel Hps1 mouse model reveal mitochondrial abnormalities and lipid accumulation in HPS‐1 kidney proximal tubule cells. Serum ApoA1 correlates with kidney function in our patient
Dawn M. Maynard   +7 more
wiley   +1 more source

Contribution of nonconsensus base pairs within ArsR binding sequences toward ArsR-DNA binding and arsenic-mediated transcriptional induction

open access: yesJournal of Biological Engineering, 2019
Background A transcriptional reporter is the key component in bacterial biosensors which are employed to monitor the induction or repression of a reporter gene corresponding to environmental change.
Xingjuan Chen   +8 more
doaj   +1 more source

Some integer sequences based on derangements [PDF]

open access: yesarXiv, 2007
Sequences whose terms are equal to the number of functions with specified properties are considered. Properties are based on the notion of derangements in a more general sense. Several sequences which generalize the standard notion of derangements are thus obtained.
arxiv  

Integrating alignment-based and alignment-free sequence similarity measures for biological sequence classification [PDF]

open access: yes, 2014
Alignment-based sequence similarity searches, while accurate for some type of sequences, can produce incorrect results when used on more divergent but functionally related sequences that have undergone the sequence rearrangements observed in many bacterial and viral genomes. Here, we propose a classification model that exploits the complementary nature
arxiv   +1 more source

Secondary structure determination of the conserved 98-base sequence at the 3' terminus of hepatitis C virus genome RNA

open access: yesJournal of Virology, 1997
The RNA genome of hepatitis C virus (HCV) terminates with a highly conserved 98-base sequence. Enzymatic and chemical approaches were used to define the secondary structure of this 3'-terminal element in RNA transcribed in vitro from cloned cDNA.
K. Blight, Charles M. Rice
semanticscholar   +1 more source

Cytosolic‐enhanced dark Epac‐based FRET sensors allow for intracellular cAMP detection in live cells via FLIM

open access: yesFEBS Letters, EarlyView.
We describe a novel set of Epac‐based FRET‐FLIM biosensors with improved fully cytosolic distribution, achieved without compromising the state‐of‐the‐art performance of our original designs, for detecting cAMP dynamics in real time in live cells with high precision and reliability.
Giulia Zanetti   +2 more
wiley   +1 more source

The complete mitogenome and phylogenetic analysis of Japanese firefly ‘Genji Botaru’ Luciola cruciata (Coleoptera: Lampyridae)

open access: yesMitochondrial DNA. Part B. Resources, 2017
We performed mitogenome analysis of Japanese firefly Luciola cruciata (Coleoptera: Lampyridae), which is unique species in Japan. It is classified into six haplotypes based on the difference of COII sequence on mitochondrial DNA.
Juri Maeda   +5 more
doaj   +1 more source

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