Molecular Oncology, EarlyView.In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton +17 more
wiley +1 more source
A METHOD POTENTIALLY USEFUL FOR ESTABLISHING BASE SEQUENCES IN CODEWORDS
, 1965 Semih Erhan +2 more
openalex +1 more source
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
Regulation of the herpes simplex virus type 1 late (γ2) glycoproteln C gene: sequences between base pairs −34 to +29 control transient expression and responsiveness to transactivation by the products of the immediate early (α) 4 and 0 genes [PDF]
, 1987 Michal Shapira +3 more
openalex +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Fundamental Sequences Based on Localization
Building on Buchholz' assignment for ordinals below Bachmann-Howard ordinal, see Buchholz 2003, we introduce systems of fundamental sequences for two kinds of relativized $\vartheta$-function-based notation systems of strength $Π^1_1{\operatorname{-CA}_0}$ and prove Bachmann property for these systems, which is essential for monotonicity properties of ...
openaire +2 more sources
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source
On the extension of basic sequences to bases [PDF]
Bulletin of the American Mathematical Society, 1974 openaire +3 more sources
DETERMINATION OF BASE SEQUENCE IN NUCLEIC ACIDS WIT THE ELECTRON MICROSCOPE: VISIBILITY OF A MARKER
, 1962 M Beer, Evangelos N. Moudrianakis
openalex +1 more source