Results 91 to 100 of about 2,679,856 (365)

Feedback cooling of a cantilever's fundamental mode below 5 mK

, 2007
We cool the fundamental mechanical mode of an ultrasoft silicon cantilever from a base temperature of 2.2 K to 2.9 +/- 0.3 mK using active optomechanical feedback.
B. C. Buchler, B. W. Chui, C. L. Degen, D. Rugar, H. J. Mamin, M. Poggio   +5 more
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Twist versus Nonlinear Stacking in Short DNA Molecules

, 2014
The denaturation of the double helix is a template for fundamental biological functions such as replication and transcription involving the formation of local fluctuational openings.
Zoli, Marco
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Microstrip filters for measurement and control of superconducting qubits

, 2013
Careful filtering is necessary for observations of quantum phenomena in superconducting circuits at low temperatures. Measurements of coherence between quantum states requires extensive filtering to protect against noise coupled from room temperature ...
Bennett, Douglas A., Chen, Wei, Longobardi, Luigi, Lukens, James E., Patel, Vijay   +4 more
core   +1 more source

Methyl esters selectivity of transesterification reaction with homogenous alkaline catalyst to produce biodiesel in batch, plug flow, and continuous stirred tank reactors [PDF]

, 2014
Selectivity concept is essential in establishing the best operating conditions for attaining maximum production of the desired product. For complex reaction such as biodiesel fuel synthesis, kinetic studies of transesterification reaction have revealed ...
Kamarudin, S. K., Nasir, N. F., W. Daud, W. R., Yaakob, Z.   +3 more
core   +3 more sources

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Temperatura do Ar no Desenvolvimento Reprodutivo de Cultivares de Oliveira

Revista Brasileira de Meteorologia
Resumo A temperatura do ar é uma das variáveis que exerce maior influencia o desenvolvimento reprodutivo da oliveira. O conhecimento dos efeitos da temperatura é vital para determinar o manejo das plantas no campo e escolher as cultivares mais adaptadas ...
Fabrina Bolzan Martins, Mábele de Cássia Ferreira, Luiz Fernando de Oliveira da Silva, Vinícius Ribeiro Moura Ramalho, Emerson Dias Gonçalves   +4 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source