Results 101 to 110 of about 3,706,301 (294)

LAMININ-5. A POTENTIAL TOOL IN DIAGNOSIS OF HEAD AND NECK SQUAMOUS CELL CARCINOMA

Zdravniški Vestnik, 2002
The heterotrimeric extracellular matrix protein laminin-5 (ln-5) is a regular constituent of the basement membrane in oral and pharyngeal mucosa consisting of the α 3, β 3 and γ 2 chain.
Hartwig Kosmehl, Alexander Berndt, Karl Michael Haas, Peter Hyckel   +3 more
doaj  

Advances in 3D Bioprinting for Breast Cancer Modeling: Tumor Microenvironment, Metastasis, and Drug Screening

Advanced Healthcare Materials, EarlyView.
Three‐dimensional bioprinting transforms breast cancer modeling from simple constructs into spatially organized, multicellular, perfused, and patient‐derived platforms. This review shows how bioinks, cellular composition, architecture, and flow govern tumor behavior and drug response, while revealing why complexity alone is insufficient without ...
Mustafa Nakipoglu, Mahboobeh Mahmoodi, Ehsanul Hoque Apu, Fahimeh Shahabipour, Sibel Emir Diltemiz, Sanjib Saha, Halima Alem, Nureddin Ashammakhi   +7 more
wiley   +1 more source

Engineering Pluripotent Stem Cells‐Derived Inner Ear Organoids With Enhanced Maturation and Reproducibility by Micro‐Topographical Cues

Advanced Materials, EarlyView.
Micro‐topographical cues applied through temporally controlled microscale confinement improve the reproducibility, spatial organization, and neurosensory‐associated features of pluripotent stem cell‐derived inner ear organoids. Integration with a vascularized organoid platform further enables controlled investigation of vascular‐epithelial interactions
Harshita Sharma, Jungeun Lim, Woochan Kim, Yeon Ju Kim, Dream Kim, Shinyull Lee, Chaeyeon Park, Stephen Rhee, Shruthy Kuttapan, Jungho Ha, Sang Wook Park, Kyunghoon Kim, Noo Li Jeon, Sunho Park, Yun‐Hoon Choung, Jangho Kim   +15 more
wiley   +1 more source

ADAP1 promotes invasive squamous cell carcinoma progression and predicts patient survival

Life Science Alliance, 2019
ADAP1, a GTPase-activating protein (GAP) for the small GTPase ARF6, is a strong predictor of poor survival in early-stage squamous cell carcinoma patients and a critical mediator of TGF-β-induced invasive cell migration by facilitating basement membrane ...
Avery Van Duzer, Sachiko Taniguchi, Ajit Elhance, Takahiro Tsujikawa, Naoki Oshimori   +4 more
doaj   +1 more source

The Basement Membrane in a 3D Breast Acini Model Modulates Delivery and Anti-Proliferative Effects of Liposomal Anthracyclines

Pharmaceuticals, 2020
Breast cancer progression is marked by cancer cell invasion and infiltration, which can be closely linked to sites of tumor-connected basement membrane thinning, lesion, or infiltration.
Tabea Wiedenhoeft, Tobias Braun, Ronald Springer, Michael Teske, Erik Noetzel, Rudolf Merkel, Agnes Csiszár   +6 more
doaj   +1 more source

Invadopodia and basement membrane invasion in vivo

Cell Adhesion & Migration, 2014
Over 20 years ago, protrusive, F-actin-based membrane structures, termed invadopodia, were identified in highly metastatic cancer cell lines. Invadopodia penetrate artificial or explanted extracellular matrices in 2D culture conditions and have been ...
L. Lohmer, L. C. Kelley, Elliott J. Hagedorn, D. Sherwood   +3 more
semanticscholar   +1 more source

Basement membrane: Carbohydrates and X-ray diffraction [PDF]

, 1969
Epithelial basement membrane, synthesized by a parietal yolk sac carcinoma in vitro or in the ascites, is free of connective tissue cells and products.
Goldstein, Irwin J., Lee, P. A., I. J. Goldstein, Blasey, K., K. Blasey, P. A. Lee, G. B. Pierces, Pierce, G. B.   +7 more
core   +1 more source

Nuclear Pore Mechanotransduction in Oncology: A Structural Axis of Vulnerability for Targeted Intervention

Advanced Materials, EarlyView.
Cancer‐associated NPC remodeling creates a high‐flux, low‐stringency nuclear state that supports malignant adaptation but increases mechanical fragility. Targeting the FG‐barrier or NPC scaffold may drive mechanostat failure, envelope rupture, DNA damage, and loss of nuclear integrity.
Sílvio Terra Stefanello, Caren Rigon Mizdal, Aline Franzen da Silva, Yun Qian, Wei‐En Yuan, Victor Shahin   +5 more
wiley   +1 more source

Cellular and Molecular Mechanisms regulating Cell Proliferation during the Forebrain Development of the Mouse [PDF]

, 2005
The predominant precursor cell type during cortical neurogenesis are radial glia cells, which receive extrinsic and intrinsic signals that might influence cell proliferation and neurogenesis.
Haubst, Nicole
core   +1 more source

Role of laminin and basement membrane in the morphological differentiation of human endothelial cells into capillary-like structures

Journal of Cell Biology, 1988
We have defined a signal responsible for the morphological differentiation of human umbilical vein and human dermal microvascular endothelial cells in vitro.
Yasuo Kubota, H. Kleinman, G. Martin, T. Lawley   +3 more
semanticscholar   +1 more source