Results 81 to 90 of about 1,150,117 (291)

Reliability and validity of the Geriatric Self-Care Scale among Chinese older adults

Annals of Medicine
Background Although the Geriatric Self-Care Scale (GSS) has been widely used in community investigations in China, its reliability and validity have yet to be analyzed.Objectives This study aimed to examine the reliability and validity of the GSS in ...
Hongji Zeng, Weijia Zhao, Rui Wang, Xin’ao Wang, Pengchao Luo, Xuyang Zhang, Xi Zeng   +6 more
doaj   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Functional capacity and associated factors among longevous senior individuals living in community: a population study in Northeastern Brazil

Fisioterapia e Pesquisa, 2014
The objective of this study was to determine the prevalence of impaired functional capacity and the associated factors in longevous elderly individuals from a city in the countryside of Northeastern Brazil.
Thaís Alves Brito, Marcos Henrique Fernandes, Raildo da Silva Coqueiro, Cleber Souza de Jesus, Roberta Freitas   +4 more
doaj   +2 more sources

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Apathy and functional disability in behavioral variant frontotemporal dementia [PDF]

, 2018
Background Behavioral variant frontotemporal dementia (bvFTD) has profound consequences on patients and their families. In this multicenter study, we investigated the contribution of cognitive and neuropsychiatric factors to everyday function at ...
Alladi, Suvarna, Almaral-Carvalho, Viviane, Bahia, Valeria S., Balthazar, Marcio L.F., Brucki, Sonia M.D., Caramelli, Paulo, Damasceno, Benito, Guimaraes, Henrique C., Hodges, John R., Lima da Silva, Thais B., Mekala, Shailaja, Mioshi, Eneida, Nitrini, Ricardo, O’Connor, Claire M., Piguet, Olivier, Yassuda, Mônica S.   +15 more
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

The Effect of Medical Check-up and Basic Physical Activities Daily Living: Panel Study on among Indoesian Elderly 1993-2000

Makara Journal of Health Research, 2010
In the 21st Century, Indonesia becomes the fourth biggest ageing country in the World as reported by the Second World Assembly on Ageing (2002). The Indonesian Household Health Survey (2001) reported 88,9% of the elderly suffered from disability ...
Indang Trihandini
doaj   +1 more source

Real-time human ambulation, activity, and physiological monitoring:taxonomy of issues, techniques, applications, challenges and limitations [PDF]

, 2013
Automated methods of real-time, unobtrusive, human ambulation, activity, and wellness monitoring and data analysis using various algorithmic techniques have been subjects of intense research. The general aim is to devise effective means of addressing the
Achumba, Ifeyinwa E., Azzi, Djamel, Bersch, Sebastian D., Khusainov, Rinat   +3 more
core   +2 more sources

Behavioral Competence Among Community Dwelling Older People with Disability in Basic Activities of Daily Living.

Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics, 2000
This study observed the status of independence in behavioral competence among older people who have any disability in basic activities of daily living (BADL) living in a rural community in Japan. Study participants (N = 76) who were regarded as bedridden were surveyed by means of a questionnaire in July to August 1996.
T, Ishizaki, S, Watanabe, T, Suzuki, H, Shibata, H, Yoshida, S, Yasumura, N, Niino   +6 more
openaire   +3 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source