Results 41 to 50 of about 148,826 (294)
Solving the mystery of human sleep schedules one mutation at a time. [PDF]
, 2013 Sleep behavior remains one of the most enigmatic areas of life. The unanswered questions range from "why do we sleep?" to "how we can improve sleep in today's society?" Identification of mutations responsible for altered circadian regulation of human ...
Fu, Ying-Hui +2 more
core +1 more source
Structure of a rare non-standard sequence k-turn bound by L7Ae protein [PDF]
, 2014 Kt-23 from Thelohania solenopsae is a rare RNA kink turn (k-turn) where an adenine replaces the normal guanine at the 2n position. L7Ae is a member of a strongly conserved family of proteins that bind a range of k-turn structures in the ribosome, box C/D
Huang, Lin, Lilley, David M J
core +3 more sources
Target Specificities of Drosophila Enhancer of split Basic Helix-Loop-Helix Proteins [PDF]
Molecular and Cellular Biology, 1999 Seven Enhancer of split genes in Drosophila melanogaster encode basic-helix-loop-helix transcription factors which are components of the Notch signalling pathway. They are expressed in response to Notch activation and mediate some effects of the pathway by regulating the expression of target genes.
B H, Jennings, D M, Tyler, S J, Bray
openaire +2 more sources
A Novel Approach to Predict Core Residues on Cancer-Related DNA-Binding Domains
Cancer Informatics, 2016 Protein–DNA interactions are involved in different cancer pathways. In particular, the DNA-binding domains of proteins can determine where and how gene regulatory regions are bound in different cell lines at different stages.
Ka-Chun Wong
doaj +1 more source
BMC Plant Biology, 2018 Background Basic helix-loop-helix/helix-loop-helix (bHLH/HLH) transcription factors play important roles in plant development. Many reports have suggested that bHLH/HLH proteins participate in brassinosteroid (BR) hormone signaling pathways to promote ...
Rui Lu +5 more
doaj +1 more source
, 2008 The key to understanding a protein's function often lies in its conformational dynamics. We develop a coarse-grained variational model to investigate the interplay between structural transitions, conformational flexibility and function of N-terminal ...
Portman, John J., Tripathi, Swarnendu
core +1 more source
Cellular Physiology and Biochemistry, 2013 Background: The Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT, HIF-1β) is a member of the basic-Helix-Loop-Helix PER/ARNT/SIM (bHLH/PAS) protein family and a vital transcriptional regulator regarding development and physiological adaptation ...
Matthias Wolff +3 more
doaj +1 more source
The Essential Basic Helix-Loop-Helix Protein FIT1 Is Required for the Iron Deficiency Response [PDF]
The Plant Cell, 2004 Regulation of iron uptake is critical for plant survival. Although the activities responsible for reduction and transport of iron at the plant root surface have been described, the genes controlling these activities are largely unknown. We report the identification of the essential gene Fe-deficiency Induced Transcription Factor 1 (FIT1), which encodes
Elizabeth P, Colangelo +1 more
openaire +2 more sources
Regulation ofArabidopsisBrassinosteroid Signaling by Atypical Basic Helix-Loop-Helix Proteins [PDF]
The Plant Cell, 2009 AbstractBasic helix-loop-helix (bHLH) proteins are highly conserved transcription factors critical for cell proliferation and differentiation. Recent studies have implicated bHLH proteins in many plant signaling processes, including brassinosteroid (BR) signaling.
Hao, Wang +5 more
openaire +2 more sources
Molecular dynamics simulation unveils the conformational flexibility of the interdomain linker in the bacterial transcriptional regulator GabR from Bacillus subtilis bound to pyridoxal 5'-phosphate [PDF]
, 2017 GabR from Bacillus subtilis is a transcriptional regulator belonging to the MocR subfamily of the GntR regulators. The structure of the MocR regulators is characterized by the presence of two domains: i) a N-terminal domain, about 60 residue long ...
Guidoni, Leonardo +4 more
core +9 more sources