Results 21 to 30 of about 148,826 (294)
Protein chainmail variants in dsDNA viruses. [PDF]
, 2015 First discovered in bacteriophage HK97, biological chainmail is a highly stable system formed by concatenated protein rings. Each subunit of the ring contains the HK97-like fold, which is characterized by its submarine-like shape with a 5-stranded β ...
Chiou, Joshua, Zhou, Z Hong
core +2 more sources
Biological Procedures Online, 2004 Post-translational modifications such as phosphorylation play a vital role in the regulation of protein function. In our study of the basic Helix-loop-Helix (bHLH) transcription factor HAND1, we show that HAND1 is phosphorylated during the trophoblast ...
Centonze Victoria E. +2 more
doaj +1 more source
Context dependence of proneural bHLH proteins [PDF]
, 2008 A key point of neural development is the commitment of progenitor cells to a specific neural fate. In all animals studied, proneural proteins — transcription factors of the basic helix-loop-helix (bHLH) family — are central to this process.
Jarman, Andrew P., Powell, Lynn M.
core +1 more source
Rap1 binding and a lipid-dependent helix in talin F1 domain promote integrin activation in tandem. [PDF]
, 2019 Rap1 GTPases bind effectors, such as RIAM, to enable talin1 to induce integrin activation. In addition, Rap1 binds directly to the talin1 F0 domain (F0); however, this interaction makes a limited contribution to integrin activation in CHO cells or ...
Alexandre R. Gingras +44 more
core +2 more sources
An exploration of alternative visualisations of the basic helix-loop-helix protein interaction network [PDF]
BMC Bioinformatics, 2007 Abstract Background Alternative representations of biochemical networks emphasise different aspects of the data and contribute to the understanding of complex biological systems. In this study we present a variety of automated methods for visualisation of a protein-protein interaction network, using the basic helix ...
Brian J. Holden +4 more
openaire +5 more sources
PLoS Genetics, 2018 The Sterol Regulatory Element Binding Proteins (SREBPs) are basic-helix-loop-helix transcription regulators that control the expression of sterol biosynthesis genes in higher eukaryotes and some fungi.
Valentina Del Olmo Toledo +3 more
doaj +1 more source
Differential Interactions of Id Proteins with Basic-Helix-Loop-Helix Transcription Factors [PDF]
Journal of Biological Chemistry, 1997 Dimerization of three Id proteins (Id1, Id2, and Id3) with the four class A E proteins (E12, E47, E2-2, and HEB) and two groups of class B proteins, the myogenic regulatory factors (MRFs: MyoD, myogenin, Myf-5 and MRF4/Myf-6), and the hematopoietic factors (Scl/Tal-1, Tal-2, and Lyl-1) were tested in a quantitative yeast 2-hybrid assay.
K, Langlands +3 more
openaire +2 more sources
Regulation of protein function by interfering protein species
Biomolecular Concepts, 2012 Most proteins do not function alone but act in protein complexes. For several transcriptional regulators, it is known that they have to homo- or heterodimerize prior to DNA binding.
Graeff Moritz, Wenkel Stephan
doaj +1 more source
Anti-tumor effects of an ID antagonist with no observed acquired resistance
npj Breast Cancer, 2021 ID proteins are helix-loop-helix (HLH) transcriptional regulators frequently overexpressed in cancer. ID proteins inhibit basic-HLH transcription factors often blocking differentiation and sustaining proliferation.
Paulina M. Wojnarowicz +26 more
doaj +1 more source
Transcriptome Analysis of Lolium temulentum Exposed to a Combination of Drought and Heat Stress
Plants, 2021 Drought and heat are two major stresses predicted to increase in the future due to climate change. Plants exposed to multiple stressors elicit unique responses from those observed under individual stresses.
Ruth C. Martin +2 more
doaj +1 more source