Results 11 to 20 of about 148,826 (294)

The Evolution of the Neural Basic Helix-Loop-Helix Proteins

The Scientific World Journal, 2001
Basic Helix-Loop-Helix (bHLH) transcription factors control various aspects of the formation of the nervous system in the metazoans. In Drosophila some bHLH (such as the achaete-scuteatonal, and amos genes) act as proneural genes, directing ectodermal ...
Michel Vervoort, Valerie Ledent
doaj   +4 more sources

Origin and diversification of basic-helix-loop-helix proteins in plants. [PDF]

Mol Biol Evol, 2010
Basic helix-loop-helix (bHLH) proteins are a class of transcription factors found throughout eukaryotic organisms. Classification of the complete sets of bHLH proteins in the sequenced genomes of Arabidopsis thaliana and Oryza sativa (rice) has defined the diversity of these proteins among flowering plants.
Pires N, Dolan L.
europepmc   +5 more sources

Phylogenetic analysis of the human basic helix-loop-helix proteins [PDF]

Genome Biology, 2002
The basic helix-loop-helix (bHLH) proteins are a large and complex multigene family of transcription factors with important roles in animal development, including that of fruitflies, nematodes and vertebrates. The identification of orthologous relationships among the bHLH genes from these widely divergent taxa allows reconstruction of the putative ...
Ledent, Valérie, Paquet, Odier, Vervoort, Michel   +2 more
openaire   +3 more sources

The basic helix-loop-helix (bHLH) proteins in breast cancer progression [PDF]

Medical Oncology, 2013
The basic helix-loop-helix (bHLH) proteins are the major transcription factors acting as transcriptional enhancers or inhibitors of various genes through binding to the canonical E-box sequence. The bHLH proteins are highly conserved in both vertebrates and invertebrates.
Kabir, Nuzhat N., Rönnstrand, Lars, Kazi, Julhash U.   +2 more
openaire   +3 more sources

Identification of interaction partners for the basic-helix – loop – helix protein E47 [PDF]

Oncogene, 1997
Helix-loop-helix proteins constitute a family of transcription factors with the potential to form homo- and hetero-dimers mediated by the helix-loop-helix domain. Oncogenic mutations in such genes can disrupt the equilibrium of protein-protein interactions in the affected cell.
T N, Dear, T, Hainzl, M, Follo, M, Nehls, H, Wilmore, K, Matena, T, Boehm   +6 more
openaire   +2 more sources

The Basic Helix-Loop-Helix Protein Family: Comparative Genomics and Phylogenetic Analysis [PDF]

Genome Research, 2001
The basic Helix-Loop-Helix (bHLH) proteins are transcription factors that play important roles during the development of various metazoans including fly, nematode, and vertebrates. They are also involved in human diseases, particularly in cancerogenesis. We made an extensive search for bHLH sequences in the completely sequenced genomes ofCaenorhabditis
Ledent, Valérie, Vervoort, Michel
openaire   +3 more sources

Multiple interfaces between a serine recombinase and an enhancer control site-specific DNA inversion. [PDF]

, 2013
Serine recombinases are often tightly controlled by elaborate, topologically-defined, nucleoprotein complexes. Hin is a member of the DNA invertase subclass of serine recombinases that are regulated by a remote recombinational enhancer element containing
Chang, Yong, Dhar, Gautam, Heiss, John K, Johnson, Reid C, McLean, Meghan M   +4 more
core   +1 more source

Dynamics at the serine loop underlie differential affinity of cryptochromes for CLOCK:BMAL1 to control circadian timing. [PDF]

, 2020
Mammalian circadian rhythms are generated by a transcription-based feedback loop in which CLOCK:BMAL1 drives transcription of its repressors (PER1/2, CRY1/2), which ultimately interact with CLOCK:BMAL1 to close the feedback loop with ~24 hr periodicity ...
Abraham, Adams, Anand, Aryal, Battye, Beckett, Berendsen, Brautigam, Bussi, Czarna, Czarna, Edwards, Emsley, Evans, Fairhead, Fuxreiter, Gao, Gekakis, Griffin, Gustafson, Hirota, Hitomi, Huang, Khan, Kim, Kiyohara, Koike, Lee, Levy, Li, Lindorff-Larsen, Liu, Liu, Ludtke, López-Llano, McClendon, McGibbon, Michael, Michael, Miyazaki, Moffett, Nangle, Ode, Park, Park, Parrinello, Partch, Partch, Patke, Pettersen, Preitner, Rapp, Rosensweig, Sancar, Sato, Scheres, Schmalen, Suloway, Takahashi, Ukai-Tadenuma, van der Horst, van Zundert, Vitaterna, Voss, Wagner, Winn, Xing, Xu, Yagita, Zhang, Zhu   +70 more
core   +3 more sources

BMP and FGF signaling interact to pattern mesoderm by controlling basic helix-loop-helix transcription factor activity

eLife, 2018
The mesodermal germ layer is patterned into mediolateral subtypes by signaling factors including BMP and FGF. How these pathways are integrated to induce specific mediolateral cell fates is not well understood.
Richard H Row, Amy Pegg, Brian A Kinney, Gist H Farr 3rd, Lisa Maves, Sally Lowell, Valerie Wilson, Benjamin L Martin   +7 more
doaj   +1 more source

Basic helix-loop-helix proteins E2A and HEB induce immature T-cell receptor rearrangements in nonlymphoid cells [PDF]

, 2001
T-cell receptor (TCR) gene rearrangements are mediated via V(D)J recombination, which is strictly regulated during lymphoid differentiation, most probably through the action of specific transcription factors.
Dongen, J.J.M. (Jacques) van, Gastel-Mol, E.J. (Ellen) van, Langerak, A.W. (Anton), Oud, M.E., Wolvers-Tettero, I.L.   +4 more
core   +2 more sources