Results 101 to 110 of about 106,709 (199)

Transcriptional regulation of the human ALDH1A1 promoter by the oncogenic homeoprotein TLX1/HOX11 [PDF]

open access: yes, 2009
The homeoprotein TLX1, which is essential to spleen organogenesis and oncogenic when aberrantly expressed in immature T cells, functions as a bifunctional transcriptional regulator, being capable of activation or repression depending on cell type and/or ...
Rice, K.L.   +4 more
core   +3 more sources

Functional Profiling of Transcription Factor Genes in Neurospora crassa. [PDF]

open access: yes, 2017
Regulation of gene expression by DNA-binding transcription factors is essential for proper control of growth and development in all organisms. In this study, we annotate and characterize growth and developmental phenotypes for transcription factor genes ...
Bekman, Thomas   +17 more
core   +1 more source

High-dimensional switches and the modeling of cellular differentiation [PDF]

open access: yes, 2004
Many genes have been identified as driving cellular differentiation, but because of their complex interactions, the understanding of their collective behaviour requires mathematical modelling.
Cinquin, O, Demongeot, J
core   +1 more source

Generation of ID1/3 knockout human embryonic stem cell lines (WAe009-A-2A and WAe009-A-2B) derived from H9 using CRISPR/Cas9

open access: yesStem Cell Research
ID1 and ID3 are the members of the Inhibitor of DNA Binding (ID) protein family, which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers, are involved in neurodevelopment, cardiovascular development, and
Yihui Li, Mingxia Du, Zibing Jin
doaj   +1 more source

Predicting variation of DNA shape preferences in protein-DNA interaction in cancer cells with a new biophysical model

open access: yes, 2017
DNA shape readout is an important mechanism of target site recognition by transcription factors, in addition to the sequence readout. Several models of transcription factor-DNA binding which consider DNA shape have been developed in recent years.
Batmanov, Kirill, Wang, Junbai
core   +2 more sources

A regulatory transcriptional loop controls proliferation and differentiation in Drosophila neural stem cells.

open access: yesPLoS ONE, 2014
Neurogenesis is initiated by a set of basic Helix-Loop-Helix (bHLH) transcription factors that specify neural progenitors and allow them to generate neurons in multiple rounds of asymmetric cell division.
Tetsuo Yasugi   +4 more
doaj   +1 more source

Ethylene Response of Plum ACC Synthase 1 (ACS1) Promoter is Mediated through the Binding Site of Abscisic Acid Insensitive 5 (ABI5). [PDF]

open access: yes, 2019
The enzyme 1-amino-cyclopropane-1-carboxylic acid synthase (ACS) participates in the ethylene biosynthesis pathways and it is tightly regulated transcriptionally and post-translationally.
Blumwald, Eduardo   +7 more
core   +1 more source

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