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The Basic Helix-Loop-Helix Transcription Factors in Neural Differentiation
2010During the development of the central nervous system, neural stem cells initially expand their own population by symmetric cell divisions, in which both progeny re-enter the cell cycle. By mid-gestation, the cells initiate neurogenesis by adopting a mode of asymmetric cell division, in which one daughter cell differentiates into a neuron while the ...
Toshiyuki Ohtsuka, Ryoichiro Kageyama
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Phosphorylation of basic helix–loop–helix transcription factor Twist in development and disease
Biochemical Society Transactions, 2012The transcription factor Twist plays vital roles during embryonic development through regulating/controlling cell migration. However, postnatally, in normal physiological settings, Twist is either not expressed or inactivated. Increasing evidence shows a strong correlation between Twist reactivation and both cancer progression and malignancy, where the
Xue Gongda, Hemmings Brian A
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A Synthetic Miniprotein Platform Targeting Basic Helix-Loop-Helix Transcription Factors
2021Transcription factors (TFs) control gene expression by recognizing specific DNA sequences, thereby regulating most, if not all, aspects of cellular function. As such, many cancers are hallmarked by deregulation of TFs, which makes them ideal targets for cancer therapy. However, direct inhibition of the DNA binding of TFs remains largely untapped due to
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Identification and analysis of the mouse basic/Helix-Loop-Helix transcription factor family
Biochemical and Biophysical Research Communications, 2006The basic/Helix-Loop-Helix (bHLH) proteins are a family of transcription factors that regulates a variety of biological processes. Based on a previously defined consensus motif, we identified the complete set of bHLH protein family from the mouse proteome databases and carried out a series of bioinformatics analysis. As results, 124 mouse bHLH proteins
Jing, Li +5 more
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Possible roles of basic helix-loop-helix transcription factors in adaptation to drought
Plant Science, 2014Water deficiency decreases plant growth and productivity. Several mechanisms are activated in response to dehydration that allows plants to cope with stress, including factors controlling stomatal aperture and ramified root system development. In addition, ABA metabolism is also implicated in the regulation of drought responses.
Graciela, Castilhos +4 more
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Journal of Cellular Biochemistry, 2009
AbstractBasic helix‐loop‐helix (bHLH) transcription factors including Twist1 and E2a proteins regulate essential processes. These factors bind DNA as homo‐ or heterodimers and the choice of binding partners determines their functional output. To investigate potential regulators of bHLH dimerization, cells were exposed to the oxidative agent hydrogen ...
Theodora E, Danciu, Malcolm, Whitman
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AbstractBasic helix‐loop‐helix (bHLH) transcription factors including Twist1 and E2a proteins regulate essential processes. These factors bind DNA as homo‐ or heterodimers and the choice of binding partners determines their functional output. To investigate potential regulators of bHLH dimerization, cells were exposed to the oxidative agent hydrogen ...
Theodora E, Danciu, Malcolm, Whitman
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Research progress on the basic helix-loop-helix transcription factors of Aspergillus species
2019Basic helix-loop-helix (bHLH) proteins belong to a superfamily of transcription factors, and they are widely distributed in eukaryotic organisms. Members of the bHLH protein family can form homodimers or heterodimers with themselves or other family members, and they often play bifunctional roles as activators and repressors to uniquely regulate the ...
Bao-Teng, Wang +6 more
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Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2013
The atonal-related Neurogenin/NeuroD family of basic helix-loop-helix (bHLH) transcription factors comprises potent inducers of neuronal and endocrine differentiation programs in the nervous and digestive system. Atonal homolog 8 (Atoh8) displays high similarity in the bHLH domain with NeuroD proteins.
Miriam, Ejarque +3 more
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The atonal-related Neurogenin/NeuroD family of basic helix-loop-helix (bHLH) transcription factors comprises potent inducers of neuronal and endocrine differentiation programs in the nervous and digestive system. Atonal homolog 8 (Atoh8) displays high similarity in the bHLH domain with NeuroD proteins.
Miriam, Ejarque +3 more
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