Synthetic Lethal Analysis of Caenorhabditis elegans Posterior Embryonic Patterning Genes Identifies Conserved Genetic Interactions [PDF]
, 2010 Phenotypic robustness is evidenced when single-gene mutations do not result in an obvious phenotype. It has been suggested that such phenotypic stability results from 'buffering' activities of homologous genes as well as non-homologous genes acting in ...
Baugh, L Ryan +5 more
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A natural classification of the basic helix–loop–helix class of transcription factors [PDF]
Proceedings of the National Academy of Sciences, 1997 A natural (evolutionary) classification is provided for 242 basic helix–loop–helix (bHLH) motif-containing proteins. Phylogenetic analyses of amino acid sequences describe the patterns of evolutionary change within the motif and delimit evolutionary lineages.
W R, Atchley, W M, Fitch
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BMC Plant Biology, 2017 Background Basic helix-loop-helix (bHLH) transcription factors (TFs), which are widely distributed in eukaryotic organisms, play crucial roles in plant development. However, no comprehensive analysis of the bHLH family in wheat (Triticum aestivum L.) has
Xiao-Jiang Guo, Ji-Rui Wang
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Cell Reports, 2021 Summary: The basic helix-loop-helix (bHLH) transcription factor PHYTOCHROME-INTERACTING FACTOR 7 (PIF7) is a central regulator that promotes stem growth by activating growth-related gene expression during shade-avoidance responses.
Chuanwei Yang +7 more
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A basic helix-loop-helix transcription factor, PhFBH4, regulates flower senescence by modulating ethylene biosynthesis pathway in petunia. [PDF]
, 2015 The basic helix-loop-helix (bHLH) transcription factors (TFs) play important roles in regulating multiple biological processes in plants. However, there are few reports about the function of bHLHs in flower senescence.
Bui, Mai +5 more
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Solving the mystery of human sleep schedules one mutation at a time. [PDF]
, 2013 Sleep behavior remains one of the most enigmatic areas of life. The unanswered questions range from "why do we sleep?" to "how we can improve sleep in today's society?" Identification of mutations responsible for altered circadian regulation of human ...
Fu, Ying-Hui +2 more
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The Basic Helix-Loop-Helix Transcription Factor HESR1 Regulates Endothelial Cell Tube Formation [PDF]
Journal of Biological Chemistry, 2001 Human endothelial cells can be induced to form capillary-like tubular networks in collagen gels. We have used this in vitro model and representational difference analysis to identify genes involved in the formation of new blood vessels. HESR1 (HEY-1/HRT-1/CHF-2/gridlock), a basic helix-loop-helix protein related to the hairy/enhancer of split/HES ...
A M, Henderson +4 more
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Genome-wide analysis of the basic Helix-Loop-Helix (bHLH) transcription factor family in maize
BMC Plant Biology, 2018 Background In plants, the basic helix-loop-helix (bHLH) transcription factors play key roles in diverse biological processes. Genome-wide comprehensive and systematic analyses of bHLH proteins have been well conducted in Arabidopsis, rice, tomato and ...
Tingting Zhang +6 more
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The bHLH transcription factors TSAR1 and TSAR2 regulate triterpene saponin biosynthesis in Medicago truncatula [PDF]
, 2015 Plants respond to stresses by producing a broad spectrum of bioactive specialized metabolites. Hormonal elicitors, such as jasmonates, trigger a complex signaling circuit leading to the concerted activation of specific metabolic pathways.
Goossens, Alain +5 more
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A Tripartite Growth Regulatory Cascade of Basic Helix-Loop-Helix Transcription Factors [PDF]
The Plant Cell, 2012 Plant growth is regulated by a multiplicity of factors, many of which are transduced via hormone signaling. However, how these hormone signals converge to affect growth is not entirely clear (reviewed in [Depuydt and Hardtke, 2011][1]). New work from [ Ikeda et al.
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