Results 81 to 90 of about 88,645 (280)

Association of Age-Related Trends in Blood Pressure and Body Composition Indices in Healthy Adults

Frontiers in Physiology, 2018
Purpose: Adiposity is one of the important determinants of blood pressure. The aim of this study is to evaluate the association between blood pressure and body composition indices throughout the whole lifespan of healthy adults.Patients and Methods: This
Wei Li, Yan He, Yan He, Lili Xia, Xinghua Yang, Feng Liu, Jingang Ma, Zhiping Hu, Yajun Li, Dongxue Li, Jiajia Jiang, Guangliang Shan, Changlong Li   +12 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Integrated rating system of sustainable construction's life cycle

, 2010
The present doctoral thesis includes the development of a holistic management system of construction, in construction activities that aim at the response of the construction to the requirements of Sustainable Development.
Siouta, Niki, Σιούτα, Νίκη
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

The German MultiCare-study : patterns of multimorbidity in primary health care - protocol of a prospective cohort study

, 2009
Background Multimorbidity is a highly frequent condition in older people, but well designed longitudinal studies on the impact of multimorbidity on patients and the health care system have been remarkably scarce in numbers until today.
Weyerer Siegfried, Gerlach, Ferdinand M., Gerlach Ferdinand M, Höfels Susanne, Bullinger, Monika, Gensichen Jochen, Rudolph, Anja, Bussche, Hendrik van den, Werle, Jochen, Wegscheider Karl, Altiner Attila, Gensichen, Jochen, Luppa Melanie, Werle Jochen, Hansen, Heike, Kaduszkiewicz, Hanna, Riedel-Heller Steffi, Wiese Birgitt, Altiner, Attila, Schulz, Sven, Bickel, Horst, Luppa, Melanie, Knesebeck, Olaf von dem, Wegscheider, Karl, Knesebeck Olaf, Schön Gerhard, Schäfer, Ingmar, Maier, Wolfgang, Petersen Juliana J, Riedel-Heller, Steffi Gerlinde, Barth, Kerstin, Schulz Sven, Hansen Heike, Bullinger Monika, Schön, Gerhard, Fuchs, Angela, Maier Wolfgang, Wiese, Birgitt, Fuchs Angela, Prokein, Jana, König Hans-Helmut, Eisele Marion, König, Hans-Helmut, Prokein Jana, Weyerer, Siegfried, Petersen, Juliana, Rudolph Anja, Bussche Hendrik, Barth Kerstin, Eisele, Marion, Bickel Horst, Schäfer Ingmar, Höfels, Susanne, Kaduszkiewicz Hanna   +53 more
core   +1 more source

ANALISIS BASIC RATING LIFE BEARING UCP 211-32 AKIBAT UNBALANCE MENGGUNAKAN METODE SKF DAN SIMULASI ANSYS PADA ALAT SIMULATOR BALANCING

Prosiding Seminar Nasional Teknologi Energi dan Mineral
Penelitian ini menganalisis lifetime dan fatigue life bearing UCP 211-32 akibat pengaruh unbalance serta variasi repeated load (2x–5x) pada alat simulator balancing. Metode yang digunakan meliputi perhitungan manual berbasis persamaan SKF dan simulasi numerik dengan ANSYS Workbench serta Discovery.
Rifandi Winadhi Mahardika, Totok Widiyanto, Nabal AmruHaq   +2 more
openaire   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

A Survey on Socio-Economic Factors in Relation to Quality of Life

جامعه شناسی کاربردی, 2009
This study has been performed by quantitative approach, survey method, and questionnaire technique.The theoretical framework has been synthesized from Maslow's theory of hierarchical needs, and humanecological-systems theory.
Habib Ahmadi, Alireza Eslam
doaj  

Sleep disorders in Parkinson's disease

Неврология, нейропсихиатрия, психосоматика, 2011
Nocturnal sleep disorders are common and clinically significant neuropsychic manifestations of Parkinson's disease (PD).Objective: to specify the clinical features of sleep disorders in patients with PD and to evaluate the impact of dopaminergic therapy ...
M. R. Nodel
doaj   +1 more source