Results 51 to 60 of about 123,197 (246)
Efficient numerical computation of the basic reproduction number for structured populations
Journal of Computational and Applied Mathematics, 2021 As widely known, the basic reproduction number plays a key role in weighing birth/infection and death/recovery processes in several models of population dynamics. In this general setting, its characterization as the spectral radius of next generation operators is rather elegant, but simultaneously poses serious obstacles to its practical determination.
Dimitri Breda +3 more
openaire +5 more sources
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Health Professionals and the Dynamics of COVID-19 in Manaus during the First Wave
Trends in Computational and Applied Mathematics, 2022 A model is made for the dynamics of the transmission of the new SARS-CoV-2 coronavirus, which caused the COVID-19 pandemic. This model is based on the Susceptible--Infectious--Recovered model with heterogeneity in the susceptible population and in the ...
R. C. Bassanezi +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Global stability of a distributed delayed viral model with general incidence rate
Open Mathematics, 2018 In this paper, we discussed a infinitely distributed delayed viral infection model with nonlinear immune response and general incidence rate. We proved the existence and uniqueness of the equilibria.
Ávila-Vales Eric +2 more
doaj +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
ANALISIS KESTABILAN LOKAL TITIK EKUILIBRIUM MODEL EPIDEMI SEIV DENGAN PERTUMBUHAN LOGISTIK
Majalah Ilmiah Matematika dan Statistika, 2022 The SEIV model uses population growth which is assumed to follow logistical growth. The model is studied then analyzed. The analysis shows that the non-endemic (disease-free) equilibrium point is locally asymptotically stable when the basic reproduction ...
Joko Harianto, Inda Puspita Sari
doaj +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Quantifying the relative effects of environmental and direct transmission of norovirus [PDF]
Royal Society Open Science, 2018 Norovirus is a common cause of outbreaks of acute gastroenteritis in health- and child-care settings, with serial outbreaks also frequently observed aboard cruise ships. The relative contributions of environmental and direct person-to-person transmission
S. Towers +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source