Results 61 to 70 of about 1,179,686 (304)

Limiting the spread of disease through altered migration patterns [PDF]

, 2015
We consider a model for an epidemic in a population that occupies geographically distinct locations. The disease is spread within subpopulations by contacts between infective and susceptible individuals, and is spread between subpopulations by the ...
McVinish, R., Pollett, P. K., Shausan, A.   +2 more
core   +2 more sources

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Transmission dynamics of the ongoing chikungunya outbreak in Central Italy. From coastal areas to the metropolitan city of Rome, summer 2017 [PDF]

, 2017
A large chikungunya outbreak is ongoing in Italy, with a main cluster in the Anzio coastal municipality. With preliminary epidemiological data, and a transmission model using mosquito abundance and biting rates, we estimated the basic reproduction number
Caputo, Beniamino, DELLA TORRE, Alessandra, Filipponi, Federico, Guzzetta, Giorgio, Manica, Mattia, Merler, Stefano, Poletti, Piero, Rosà, Roberto, Solimini, ANGELO GIUSEPPE   +8 more
core   +2 more sources

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Edge-based compartmental modelling of an SIR epidemic on a dual-layer static-dynamic multiplex network with tunable clustering [PDF]

, 2018
The duration, type and structure of connections between individuals in real-world populations play a crucial role in how diseases invade and spread. Here, we incorporate the aforementioned heterogeneities into a model by considering a dual-layer static ...
Barnard, Rosanna C, Berthouze, Luc, Kiss, Istvan Z, Miller, Joel C   +3 more
core   +3 more sources

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

SEIR epidemiological model with varying infectivity and infinite delay [PDF]

, 2008
A new SEIR model with distributed infinite delay is derived when the infectivity depends on the age of infection. The basic reproduction number R-0, which is a threshold quantity for the stability of equilibria, is calculated.
Röst, Gergely
core   +1 more source

On the basic reproduction number in a random environment

Journal of Mathematical Biology, 2012
The concept of basic reproduction number R0 in population dynamics is studied in the case of random environments. For simplicity the dependence between successive environments is supposed to follow a Markov chain. R0 is the spectral radius of a next-generation operator.
/Bacaër, Nicolas, Khaladi, M.
openaire   +5 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Evaluating different epidemiological models with the identical basic reproduction number ℛ0

Journal of Biological Dynamics, 2020
Epidemiological models with the identical basic reproduction number $ \mathcal {R}_0 $ may behave differently on both short time scale and long time scale.
Fan Bai
doaj   +1 more source