Results 71 to 80 of about 123,197 (246)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
The basic reproduction number of vector-borne plant virus epidemics
Virus Research, 2017 The basic reproduction number R0 is a key parameter in plant disease epidemiology, which largely determines whether or not an epidemic will occur in a plant population. The next generation matrix approach to deriving and calculating the basic reproduction number of a plant virus epidemic is described.
Van den Bosch, F, Jeger, MJ
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Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
The linear stability and basic reproduction numbers for autonomous FDEs
Discrete and Continuous Dynamical Systems - S, 2023 In this paper, we first prove the stability equivalence between a linear autonomous and cooperative functional differential equation (FDE) and its associated autonomous and cooperative system without time delay. Then we present the theory of basic reproduction number $\mathcal{R}_0$ for general autonomous FDEs.
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Basic Reproduction Numbers for a Class of Reaction-Diffusion Epidemic Models
Bulletin of Mathematical Biology, 2020 We study the basic reproduction numbers for a class of reaction-diffusion epidemic models that are developed from autonomous ODE systems. We present a general numerical framework to compute such basic reproduction numbers; meanwhile, the numerical formulation provides useful insight into their characterizations.
Yang, Chayu, Wang, Jin
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Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Results in Control and OptimizationThis study presents a mathematical model to investigate the patterns of transmission in lymphatic filariasis. The model considers chronic, acute, and asymptomatic individuals and integrates key control strategies.
Mussa A. Stephano +2 more
doaj +1 more source
Journal of Applied Sciences and Environmental Management, 2016 In this work we present an infection-age-structured mathematical model of AIDS disease dynamics and examine the endemic equilibrium state for stability.
T.T. Ashezua +2 more
doaj +1 more source
The basic reproduction number in epidemic models with periodic demographics
Journal of Biological Dynamics, 2009 Patterns of contact in social behaviour and seasonality due to environmental influences often affect the spread and persistence of diseases. Models of epidemics with seasonality and patterns in the contact rate include time-periodic coefficients, making the systems nonautonomous.
Curtis L, Wesley, Linda J S, Allen
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source