Results 71 to 80 of about 1,121,626 (305)

The Basic Reproductive Number for Disease Systems with Multiple Coupled Heterogeneities [PDF]

Mathematical Biosciences, 2017
AbstractIn mathematical epidemiology, a well-known formula describes the impact of heterogeneity on the basic reproductive number,R0, for situations in which transmission is separable and for which there is one source of variation in susceptibility and one source of variation in infectiousness.
Lloyd, Alun L., Kitron, Uriel, Perkins, T. Alex, Vazquez-Prokopec, Gonzalo M., Waller, Lance A.   +4 more
openaire   +5 more sources

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

Molecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé, Lisa Hahnefeld, Katharina J. Wenger, Donat Kögel, Joachim Steinbach, Gerd Geisslinger, Michael W. Ronellenfitsch, Irmgard Tegeder   +7 more
wiley   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

A realistic two-lane traffic model for highway traffic [PDF]

, 2002
A two-lane extension of a recently proposed cellular automaton model for traffic flow is discussed. The analysis focuses on the reproduction of the lane usage inversion and the density dependence of the number of lane changes. It is shown that the single-
A Schadschneider, Brackstone M, Esser J, Gang-Len Chang, Huberman B A, Kaumann O, Kerner B S, Knospe W, Knospe W, L Santen, Leutzbach W, M Schreckenberg, Nagatani T, Nagatani T, Nagel K, Rickert M, Salem H H, Sparmann U, W Knospe, Wagner P   +19 more
core   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Global stability of a distributed delayed viral model with general incidence rate

Open Mathematics, 2018
In this paper, we discussed a infinitely distributed delayed viral infection model with nonlinear immune response and general incidence rate. We proved the existence and uniqueness of the equilibria.
Ávila-Vales Eric, Canul-Pech Abraham, Rivero-Esquivel Erika   +2 more
doaj   +1 more source

MODEL MATEMATIKA PENYEBARAN PENYAKIT PULMONARY TUBERCULOSIS DENGAN PENGGUNAAN MASKER MEDIS

Barekeng, 2020
This research developed a model of tuberculosis disease spread using the SIR model with addition of the medical mask usage factor. First, we create a diagram of the tuberculosis disease spread compartment through contact between individuals with medical ...
Nur Inayah, Muhammad Manaqib, Nina Fitriyati, Ikhwal Yupinto   +3 more
doaj   +1 more source

Computation of the basic reproduction numbers for reaction-diffusion epidemic models

Mathematical Biosciences and Engineering, 2023
<abstract><p>We consider a class of $ k $-dimensional reaction-diffusion epidemic models ($ k = 1, 2, \cdots $) that are developed from autonomous ODE systems. We present a computational approach for the calculation and analysis of their basic reproduction numbers.
Yang, Chayu, Wang, Jin
openaire   +3 more sources

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Mathematical Modeling for Hospitalization due to Temperature Variations [PDF]

International Journal of Mathematical, Engineering and Management Sciences, 2019
Sudden changes in temperature occur due to ecological disturbances which results into global warming, volcanic eruption, depletion of ozone layer etc. This has become a crucial environmental and social issue all over the world.
Nita H. Shah, Purvi M. Pandya, Moksha H. Satia, Foram A. Thakkar   +3 more
doaj   +1 more source