Results 81 to 90 of about 1,179,686 (304)

Modelling repeated epidemics with general infection kernels [PDF]

, 2004
An integral equation approach is taken to explore the characteristics of a general infectious disease in a homogeneous population. It is shown that the final size of the epidemic depends on the basic reproduction ratio for the infection and the ...
Mann, J., Roberts, M.
core  

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Threshold dynamics of a periodic SIR model with delay in an infected compartment

Mathematical Biosciences and Engineering, 2014
Threshold dynamics of epidemic models in periodic environmentsattract more attention. But there are few papers which are concernedwith the case where the infected compartments satisfy a delaydifferential equation.
Zhenguo Bai
doaj   +1 more source

On the Dynamics of Dengue Virus type 2 with Residence Times and Vertical Transmission

, 2016
A two-patch mathematical model of Dengue virus type 2 (DENV-2) that accounts for vectors' vertical transmission and between patches human dispersal is introduced. Dispersal is modeled via a Lagrangian approach.
Bichara, Derdei, Castillo-Chavez, Carlos, Holechek, Susan A., Murillo, Anarina L., Velazquez-Castro, Jorge   +4 more
core   +2 more sources

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Models for the spread and persistence of hantavirus infection in rodents with direct and indirect transmission

Mathematical Biosciences and Engineering, 2009
Hantavirus, a zoonotic disease carried by wild rodents, is spread among rodents via direct contact and indirectly via infected rodent excreta in the soil.
Curtis L. Wesley, Linda J. S. Allen, Michel Langlais   +2 more
doaj   +1 more source

Mathematical Modeling for Hospitalization due to Temperature Variations [PDF]

International Journal of Mathematical, Engineering and Management Sciences, 2019
Sudden changes in temperature occur due to ecological disturbances which results into global warming, volcanic eruption, depletion of ozone layer etc. This has become a crucial environmental and social issue all over the world.
Nita H. Shah, Purvi M. Pandya, Moksha H. Satia, Foram A. Thakkar   +3 more
doaj   +1 more source

The Basic Reproductive Number for Disease Systems with Multiple Coupled Heterogeneities [PDF]

Mathematical Biosciences, 2017
AbstractIn mathematical epidemiology, a well-known formula describes the impact of heterogeneity on the basic reproductive number,R0, for situations in which transmission is separable and for which there is one source of variation in susceptibility and one source of variation in infectiousness.
Lloyd, Alun L., Kitron, Uriel, Perkins, T. Alex, Vazquez-Prokopec, Gonzalo M., Waller, Lance A.   +4 more
openaire   +3 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source