Results 161 to 170 of about 113,312 (290)

Preoperative Low Serum Basophil Levels Predict Poor Prognosis for the Patients with Esophageal Squamous Cell Carcinoma. [PDF]

Ann Thorac Cardiovasc Surg
Shiratori F, Yajima S, Suzuki T, Oshima Y, Yamakawa T, Ohtsuka Y, Shimada H.   +6 more
europepmc   +1 more source

Bruton tyrosine kinase (Btk) in neutrophils is indispensable for initiating and maintaining skin inflammation in a model of pemphigoid diseases

British Journal of Pharmacology, EarlyView.
Background and Purpose Bruton tyrosine kinase (Btk) is essential for B cell function. Its role in myeloid cells is less understood. Greater insights into Btk significance in myeloid cells are needed to evaluate its potential as a therapeutic target during the effector phase of antibody‐induced autoimmune diseases, where inhibiting autoantibody ...
Henning Olbrich, Paul Schilf, Sripriya Murthy, Sina Gonther, Mareike Neumann, Christoph M. Hammers, Jasper N. Pruessmann, Christian D. Sadik   +7 more
wiley   +1 more source

Human blood cell traits and sporadic lymphangioleiomyomatosis: results from mediation joint multi-omics and eQTL Mendelian randomization analysis. [PDF]

Orphanet J Rare Dis
Liu T, Cai Y.
europepmc   +1 more source

Safety, tolerability, pharmacokinetics and pharmacodynamics of the spleen tyrosine kinase inhibitor BI 894416 in healthy volunteers and patients with asthma

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Spleen tyrosine kinase (SYK) has broad biological functions in inflammation and immunity. The orally administered SYK inhibitor BI 894416 was investigated in a single‐rising‐dose Phase I study in healthy volunteers and in a combined single‐ and multiple‐rising‐dose Phase Ib study in patients with mild asthma ...
Saskia Carstensen‐Aurèche, Tobias Litzenburger, Dorothy De Sousa, Reinhard Sailer, Ewald Benediktus, Denis Delic, Fabian Müller, Meike Müller, Jens M. Hohlfeld   +8 more
wiley   +1 more source

Editorial: The fundamental biology of basophils in health and disease

Frontiers in Immunology, 2023
Christophe Pellefigues, Christophe Pellefigues, Hajime Karasuyama   +2 more
doaj   +1 more source

Allergen extract outperforms molecular components in basophil activation test in a pediatric cohort. [PDF]

Front Immunol
Chhing A, Choi S, Khelifi-Touhami D, Abbas A, Ballot E, Cottel N, Saf S, Germain G, Lambert N, Challier P, Pauliat S, Lemoine A, Bourgoin-Heck M, Just J, Wanin S, Chantran Y.   +15 more
europepmc   +1 more source

Novel drugs approved by the EMA, the FDA and the MHRA in 2025: A year in review

British Journal of Pharmacology, EarlyView.
Abstract In the 2025 novel drug mini‐review, one can take a full measure of the ingenuity that underlies current drug design and development, despite the year's smaller harvest (46 novel drugs) compared to 2024 (53) and 2023 (70). 54% of the novel drugs are first‐in‐class (FIC).
Andreas Papapetropoulos, Stavros Topouzis, Steve P. H. Alexander, Miriam M. Cortese‐Krott, Zsuzsanna Helyes, Kirill Martemyanov, Claudio Mauro, Nithyanandan Nagercoil, Reynold A. Panettieri Jr, Hemal H. Patel, Rainer Schulz, Barbara Stefanska, Gary J. Stephens, Nathalie Vergnolle, Xin Wang, Stephen Ward, Péter Ferdinandy   +16 more
wiley   +1 more source

Low levels of serum albumin and blood basophils as 10-year mortality predictors in a nationwide Korean COPD cohort. [PDF]

Sci Rep
Park HJ, Song Y, Kim Y, Ahn JH, Lee CY, Kim DK, Moon JY, Lee WY, Yoo KH, Byun MK.   +9 more
europepmc   +1 more source

IgE to Galactose-α-1,3-Galactose (α-Gal) and Relevance to Ustekinumab First-Dose Infusion Reactions and Allergenicity. [PDF]

JGH Open
Venkat PG, Nehrbas JF, Bortz PS, Platts-Mills TA, Behm BW, Figueroa EJ, Wilson JM.   +6 more
europepmc   +1 more source

Can a basophil activation test of cord blood predict a cow's milk allergy? [PDF]

Clin Exp Pediatr
Kocacik Uygun DF, Burgucu D, Uygun V, Bulbul GA, Duyar F, Sahnal CY, Bingöl A.   +6 more
europepmc   +1 more source