Results 51 to 60 of about 376,238 (287)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Isopropyl alcohol recovery by heteroazeotropic batch distillation [PDF]

, 2010
Solvent recovery is becoming a major issue in the pharmaceutical and specialty chemical industries. Solvent recovery by conventional batch distillation is limited by the frequent presence of azeotropes in the used solvent mixtures.
Van Baelen, Guy, Vreysen, Steven, Geens, Jeroen, Gerbaud, Vincent, Rodríguez-Donis, Ivonne, Janssens, Bart   +5 more
core  

A two-stage bulk-service queueing model with rework, closedown and multiple vacations

Mathematics in Applied Sciences and Engineering
In the manufacturing industry, the quality of products is of great significance in the preservation of the brand image. Quality inspection is defined as a procedure for ensuring the compliance, reliability, uniformity, and standard of a specific product.
S. Karpagam, R. Lokesh
doaj   +1 more source

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

FEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli, Carlotta Chiesa, Maher Abou Hachem, Ditte Hededam Welner   +3 more
wiley   +1 more source

A CATASTROPHIC-CUM-RESTORATIVE QUEUING SYSTEM WITH CORRELATED BATCH ARRIVALS AND VARIABLE CAPACITY [PDF]

, 2008
In this paper, we study a catastrophic-cum-restorative queuing system with correlated batch arrivals and service in batches of variable sizes. We perform the transient analysis of the queuing model.
Kumar, Rakesh, Rakesh Kumar
core   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Shortage Policies for a Jump Process with Positive and Negative Batch Arrivals in a Random Environment

Mathematics
We study a continuous-review stock management of a retailer for a single item in a limited storage (buffer) in a random environment. The stock level fluctuates according to two independent compound Poisson processes with discrete amounts of items ...
Yonit Barron
doaj   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

EIGENVALUE EXPRESSION FOR A BATCH MARKOVIAN ARRIVAL PROCESS

Journal of the Operations Research Society of Japan, 1997
Summary: Consider a batch Markovian arrival process (BMAP) as the counting process of an underlying process representing the state of environment. Such a process is useful for representing correlated inputs for example. They are used both as a modeling tool and as a theoretical device to represent and approximate superposition of input processes and ...
Nishimura, Shoichi, Sato, Hajime
openaire   +2 more sources