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Bax: Addressed to kill

Biochimie, 2011
The pro-apoptototic protein Bax (Bcl-2 Associated protein X) plays a central role in the mitochondria-dependent apoptotic pathway. In healthy mammalian cells, Bax is essentially cytosolic and inactive. Following a death signal, the protein is translocated to the outer mitochondrial membrane, where it promotes a permeabilization that favors the release ...
Stephen Manon
exaly   +3 more sources

Characterisation of the Bax-nucleophosmin interaction: the importance of the Bax C-terminus

open access: yesApoptosis, 2008
The molecular chaperone nucleophosmin has been identified as a novel Bax binding protein with this interaction proposed to be a key event in the activation and translocation of Bax in mitochondrial dysfunction and apoptotic cell death. Using a proximity assay, we have quantitatively defined the high affinity and saturable interaction between Bax and ...
Thompson, Jane   +6 more
openaire   +4 more sources

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