Effect of EZH2 Inhibition on Colorectal Cancer Cells: an In Vitro Study [PDF]
Journal of Genetic Resources, 2016 Recently, the epigenetic modifications have been recognized as a regulator of gene expression in various cancers. EZH2 gene is one the most important component of the PRC2 complex. Overexpression of EZH2 was identified in multiple cancers that considered
Farnia Ghafouri Sabzevari +3 more
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An Autoinhibited Dimeric Form of BAX Regulates the BAX Activation Pathway [PDF]
Molecular Cell, 2016 Pro-apoptotic BAX is a cell fate regulator playing an important role in cellular homeostasis and pathological cell death. BAX is predominantly localized in the cytosol, where it has a quiescent monomer conformation. Following a pro-apoptotic trigger, cytosolic BAX is activated and translocates to the mitochondria to initiate mitochondrial dysfunction ...
Thomas P, Garner +9 more
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Effects of carfilzomib alone and in combination with cisplatin on the gene expression of Bcl-2 and Bax in ovarian carcinoma cell lines [PDF]
Journal of Preventive and Complementary MedicineBackground: Carfilzomib (CFZ), a proteasome inhibitor, has demonstrated potential in the treatment of ovarian cancer, including variants that are resistant to cisplatin (Cis).Objectives: This study aims to evaluate the effects of CFZ, both as a ...
Alireza Saedi +6 more
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The Induction of Apoptosis by Resveratrol Through Regulatory Effect of miR-21 on the Gene Expression of Bcl2 and Bax in HCT-116 Cells [PDF]
Avicenna Journal of Medical Biochemistry, 2019 Background: Resveratrol (RezV) which is found in several plants including grapes and types of berries has a vital role in inducing apoptosis and suppressing cell proliferation.
Nooshin Shabab +2 more
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Pharmacological inhibition of Bax-induced cell death: Bax-inhibiting peptides and small compounds inhibiting Bax [PDF]
Experimental Biology and Medicine, 2019 Bax is an essential mediator of mitochondria-dependent programed cell death. Bax belongs to the Bcl-2 family of proteins and its activities are regulated through interaction with other member proteins in the Bcl-2 family. To date, several apoptosis-inducing drugs activating Bax have been developed, and some of them are already in the market as ...
Kelsey, Jensen +4 more
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Креативная хирургия и онкология, 2017 Previously, we designed DTCM-glutarimide as a novel anti-inflammatory agent inhibiting macrophage activation. It also showed anti-inflammatory activity in vivo.
A. Kaneda, Sh. Kh. Gantsev, K. Umezawa
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Effects of melatonin addition to the cold storage medium on cumulus oocyte complex apoptosis, viability and in vitro maturation rates of cat oocytes [PDF]
Kafkas Universitesi Veteriner Fakültesi Dergisi, 2022 Usage of oocytes obtained from ovaries aft er long-term cold storage for in vitro embryo production is a promising tool for the protection of wildlife and endangered animal species. Mammalian oocytes are susceptible to oxidative stress with regard to the
Ramazan ARICI +13 more
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Diagnostic Pathology, 2012 Background In many tumors including ovarian cancer, cell proliferation and apoptosis are important in pathogenesis and there are many alterations in most of the genes related to the cell cycle.
Ozer Hatice +5 more
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Di-san junyi daxue xuebao, 2020 Objective To study the protective effect of Lycium barbarum polysaccharide (LBP) against apoptosis of small intestinal epithelial cells (IECs) in mice with radiation-induced intestinal injury and explore the pathway that mediates this effect.
ZHANG Lei +4 more
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Cumulative exposure to solar ultraviolet A & B increases apoptosis of peripheral blood cutaneous lymphocyte antigen (CLA)+ T-Lymphocytes in outdoor workers [PDF]
JDVI (Journal of General Procedural Dermatology & Venereology Indonesia), 2018 Background: Exposure to ultraviolet A & B (UVA-UVB) plays a role in the survival of human life, but it may cause negative effects, such as immunosuppression and skin cancer.
Afif Nurul Hidayati +3 more
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