Results 81 to 90 of about 198,523 (293)

SOX5 Orchestrates Malignant Evolution via Promoter‐Centric Chromatin Remodeling in MYC‐Driven B‐Cell Lymphoma

Advanced Science, EarlyView.
In MYC‐enforced B‐cell lymphoma, SOX5 occupies promoter‐proximal regulatory regions and is associated with reduced chromatin accessibility at the PCNP locus. PCNP repression promotes proliferative remodeling by limiting apoptosis and cell‐cycle restraint.
Yiyou Mao, Zhenyuan Jia, Xiao‐Qin Mu, Ruilin Wang, Jianli Ma, Qingyuan Zhang, Yuwei Deng   +6 more
wiley   +1 more source

Combined Effects of Regular Aerobic Exercise with Vitamin D Supplementation on Some Apoptosis Indices in the Lung of Rats Exposed to Hydrogen Peroxide

Medical Laboratory Journal, 2019
Background and Objectives: Exercise is a strong physiological stimulus that can affect apoptosis in the lungs by altering a number of extracellular and intracellular signaling pathways.
somayeh ramezani, Maghsoud peeri, Mohammad Ali Azarbaijani, Firoozeh Dehghan   +3 more
doaj  

Hair growth potential of Salvia plebeia extract and its associated mechanisms

Pharmaceutical Biology, 2020
Context Although Salvia plebeia (SP) R. Brown (Labiatae) is known to possess various biological activities, the effects of SP on hair growth have not been elucidated.
Guang-Ri Jin, Yi-Lin Zhang, Jonathan Yap, William A. Boisvert, Bog-Hieu Lee   +4 more
doaj   +1 more source

Cancer‐Associated BCL‐2 Mutants Reveal Mechanisms Towards Venetoclax Resistance

Advanced Science, EarlyView.
Venetoclax (VEN) resistance in chronic lymphocytic leukemia arises from diverse BCL2 mutations. We map mechanisms contributing to VEN resistance across common BCL‐2 variants. G101V and D103Y reduce drug binding and increase sequestration of pro‐apoptotic proteins. V156D blocks VEN allosterically.
Jonas Aufdermauer, Ian de Ridder, Mahjoobeh Ehsani, Marasim Khan, Justin Kale, Lukas P. Frenzel, David Andrews, Spyridoula Karamanou, Ana J. Garcia‐Saez, Geert Bultynck   +9 more
wiley   +1 more source

اثر تمرینات هوازی تداومی و تناوبی بر بیان ژن‌های p53 و Bax و ارتباط آن با استرس اکسیداتیو و مرگ برنامه‌ریزی‌شده سلولی در میوکارد رت‌های مبتلا به انفارکتوس [PDF]

Majallah-i Dānishkadah-i Pizishkī-i Dānishgāh-i ̒ Ulūm-i Pizishkī-i Mashhad.
مقدمه: آنفارکتوس میوکارد (MI) یکی از عوامل اصلی مرگ‌ومیر قلبی‌عروقی در جهان است که باعث ایجاد استرس اکسیداتیو و مرگ برنامه‌ریزی‌شده سلولی در بافت قلب می‌شود. این مطالعه تأثیر تمرینات هوازی تداومی (MICT) و تناوبی با شدت بالا (HIIT) را بر بیان ژن‌های p53 و
بهاره مردانی, سعید کشاورز, حسین مجتهدی, لیلا صرامی   +3 more
doaj   +1 more source

Variations sur Cadet Roussel [music] /

, 1920
J.W.C. 3835 (Publisher number). For voice and piano.; Title from list t.p.; "Harmonisées par Arnold Bax, Frank Bridge, Eugène Goossens, John Ireland."; Individual sections within the work by each of the composers are marked with their initials.; Pl. no.:
Bax, Arnold, 1883-1953.
core  

Human Dental Pulp Stem Cell Secretome Restores Ischemic Stroke–Impaired Motor and Cognitive Functions by Reprogramming Redox and Inflammatory Signaling

Advanced Science, EarlyView.
Human dental pulp stem cell secretome emerges as a cell‐free therapeutic strategy for ischemic stroke by reprogramming redox and inflammatory signaling. hDPSC secretome‐derived antioxidant and immunomodulatory factors suppress the TLR4–NOX–ROS–NF‐κB axis, reduce microglial inflammatory responses and apoptosis, and promote neurogenesis, angiogenesis ...
Kyung‐Joo Seong, Sehoon Park, Sun‐Woong Bae, Daseul Kim, Jin Ho Lee, Won‐Seok Choi, Zee‐Yong Park, Ji‐Yeon Jung, Won‐Jae Kim   +8 more
wiley   +1 more source

Bax clustering under apoptotic stress.

, 2012
A) Bax clustering- MCF-7 cells stably expressing GFP-Bax were incubated 6 hours at 37°C with the different conditions and nuclei were stained with Hoechst (100 ng/mL).
Yara Reis (187851), Roland Eils (90), Marti Bernardo-Faura (187859), Benedikt Brors (14082), Thomas Wolf (136760), Anne Hamacher-Brady (177723), Daniela Richter (187864), Nathan R. Brady (51959)   +7 more
core   +1 more source

Engineering‐Modulated Molybdenum Enzymes Strategy for Tumor‐Specific Metabolic‐Immunotherapy

Advanced Science, EarlyView.
Biodegradable molybdenum sulfide nanoparticles were synthesized via a one‐pot strategy to increase molybdenum enzyme activity and thus effectively potentiate anti‐tumor immunity by integrating molybdenum‐based metalloimmunotherapy with hydrogen sulfide gas therapy.
Xiaoxiao Pan, Zifan Pei, Jie Wu, Nan Jiang, Qian Li, Yuqi Yang, Jie Cao, Yechen Huang, Shumin Sun, Qialu Du, Zhicheng Liu, Lin Zhang, Fei Gong, Jinhua Zhou, Liang Cheng   +14 more
wiley   +1 more source

Aberrant GRP78 Phase Transition Sustains Endothelial IRE1α Signaling and Drives Blood–Brain Barrier Failure in Cerebral Amyloid Angiopathy

Advanced Science, EarlyView.
Vascular Aβ40 corrupts GRP78 phase behavior in brain endothelial cells, sustaining IRE1α–TRAF2–JNK signaling and driving apoptosis, tight junction loss, and blood–brain barrier failure in cerebral amyloid angiopathy. Pharmacological IRE1α inhibition restores vascular integrity, reduces leakage, and improves functional outcomes, revealing a targetable ...
Honglin Zheng, Qiang Li, Haiyang Luo, Yapei Yuan, Na Zhang, Yongting Lu, Suying Duan, Jieshi Zhong, Hang Zhang, Chenyang Liu, Yaochong Zhang, Wenzhuo Zhao, Yaxuan Song, Tuo Wang, Si Yan, Yapeng Li, Han Liu, Yuan Gao, Zongping Xia, Yuming Xu   +19 more
wiley   +1 more source