Results 11 to 20 of about 197,763 (291)

An Autoinhibited Dimeric Form of BAX Regulates the BAX Activation Pathway [PDF]

Molecular Cell, 2016
Pro-apoptotic BAX is a cell fate regulator playing an important role in cellular homeostasis and pathological cell death. BAX is predominantly localized in the cytosol, where it has a quiescent monomer conformation. Following a pro-apoptotic trigger, cytosolic BAX is activated and translocates to the mitochondria to initiate mitochondrial dysfunction ...
Thomas P, Garner, Denis E, Reyna, Amit, Priyadarshi, Hui-Chen, Chen, Sheng, Li, Yang, Wu, Yogesh Tengarai, Ganesan, Vladimir N, Malashkevich, Emily H, Cheng, Evripidis, Gavathiotis   +9 more
openaire   +4 more sources

Clinical and biochemical improvements in a patient with MNGIE following enzyme replacement. [PDF]

, 2013
Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is a rare autosomal recessive metabolic disorder caused by a deficiency of thymidine phosphorylase (TP, EC2.4.2.4) due to mutations in the nuclear gene TYMP.
Bax, BE, Tonin, P, Bax B. E., Moran N., SCARPELLI, Mauro, Tonin P., Scarpelli M., Filosto M., Bain, MD, TONIN, PAOLA, Scarpelli, M, Filosto, M, Moran, N, Bain M. D.   +13 more
core   +1 more source

Reversal of Hyperglycemia and Suppression of Type 1 Diabetes in the NOD Mouse with Apoptotic DNA Immunotherapy™ (ADi™), ADi-100

Biomedicines, 2020
The antigen-specific apoptotic DNA immunotherapeutic, ADi-100, is designed to suppress type 1 diabetes and consists of two DNA plasmids encoding genetic sequences of the apoptosis-inducing molecule, BAX, and the secreted form of the autoantigen, glutamic
David G. Alleva, Melika Rezaee, Linda Yip, Gang Ren, Jarrett Rosenberg, Waldo Concepcion, Alan Escher, Shahrokh Shabahang, Avnesh S. Thakor   +8 more
doaj   +1 more source

Effect of EZH2 Inhibition on Colorectal Cancer Cells: an In Vitro Study [PDF]

Journal of Genetic Resources, 2016
Recently, the epigenetic modifications have been recognized as a regulator of gene expression in various cancers. EZH2 gene is one the most important component of the PRC2 complex. Overexpression of EZH2 was identified in multiple cancers that considered
Farnia Ghafouri Sabzevari, Madjid Momeni-Moghaddam, Faris Farassati, Abolfazl Rad   +3 more
doaj   +1 more source

Effects of carfilzomib alone and in combination with cisplatin on the gene expression of Bcl-2 and Bax in ovarian carcinoma cell lines [PDF]

Journal of Preventive and Complementary Medicine
Background: Carfilzomib (CFZ), a proteasome inhibitor, has demonstrated potential in the treatment of ovarian cancer, including variants that are resistant to cisplatin (Cis).Objectives: This study aims to evaluate the effects of CFZ, both as a ...
Alireza Saedi, Javad Zavar Reza, Navid Ghasemzadeh, Moein Moradi, Behnaz Majidi, Amir Hossein Fatehi Marj, Sadegh Zarei   +6 more
doaj   +1 more source

The Induction of Apoptosis by Resveratrol Through Regulatory Effect of miR-21 on the Gene Expression of Bcl2 and Bax in HCT-116 Cells [PDF]

Avicenna Journal of Medical Biochemistry, 2019
Background: Resveratrol (RezV) which is found in several plants including grapes and types of berries has a vital role in inducing apoptosis and suppressing cell proliferation.
Nooshin Shabab, Saeid Afshar, Massoud Saidijam   +2 more
doaj   +1 more source

Pharmacological inhibition of Bax-induced cell death: Bax-inhibiting peptides and small compounds inhibiting Bax [PDF]

Experimental Biology and Medicine, 2019
Bax is an essential mediator of mitochondria-dependent programed cell death. Bax belongs to the Bcl-2 family of proteins and its activities are regulated through interaction with other member proteins in the Bcl-2 family. To date, several apoptosis-inducing drugs activating Bax have been developed, and some of them are already in the market as ...
Kelsey, Jensen, David Jasen, WuWong, Sean, Wong, Mieko, Matsuyama, Shigemi, Matsuyama   +4 more
openaire   +2 more sources

INHIBITION OF CELLULAR INVASION AND INDUCTION OF ANOIKIS IN MOUSE MELANOMA CELLS BY AN ANTI-INFLAMMATORY AGENT DTCM-GLUTARIMIDE

Креативная хирургия и онкология, 2017
Previously, we designed DTCM-glutarimide as a novel anti-inflammatory agent inhibiting macrophage activation. It also showed anti-inflammatory activity in vivo.
A. Kaneda, Sh. Kh. Gantsev, K. Umezawa
doaj   +1 more source

Immunohistochemistry with apoptotic-antiapoptotic proteins (p53, p21, bax, bcl-2), c-kit, telomerase, and metallothionein as a diagnostic aid in benign, borderline, and malignant serous and mucinous ovarian tumors

Diagnostic Pathology, 2012
Background In many tumors including ovarian cancer, cell proliferation and apoptosis are important in pathogenesis and there are many alterations in most of the genes related to the cell cycle.
Ozer Hatice, Yenicesu GoncaImir, Arici Sema, Cetin Meral, Tuncer Ersin, Cetin Ali   +5 more
doaj   +1 more source

Lycium barbarum polysaccharide inhibits apoptosis of intestinal epithelial cells through mitochondrial pathway in mice with radiation-induced intestinal injury

Di-san junyi daxue xuebao, 2020
Objective To study the protective effect of Lycium barbarum polysaccharide (LBP) against apoptosis of small intestinal epithelial cells (IECs) in mice with radiation-induced intestinal injury and explore the pathway that mediates this effect.
ZHANG Lei, WANG Zhengjie, LI Wenbo, LI Jia, HUANG Huan   +4 more
doaj   +1 more source