Results 11 to 20 of about 144,672 (262)

Activation of apoptosis and G0/G1 cell cycle arrest along with inhibition of melanogenesis by humic acid and fulvic acid: BAX/BCL-2 and Tyr genes expression and evaluation of nanomechanical properties in A375 human melanoma cell line [PDF]

Iranian Journal of Basic Medical Sciences, 2022
Objective(s): Humic acid (HA) and Fulvic acid (FA) are major members of humic substances, which are extracted from organic sources including soil and peat.
Mitra Salehi, Hossein Piri, Alireza Farasat, Babak Pakbin, Nematollah Gheibi   +4 more
doaj   +1 more source

Assessment of the effect of CoFe2O4@Ag synthesized by Spirulina platensis on colon cancer cell line and evaluation the expression of BAX and Bcl-2 genes [PDF]

Journal of Epigenetics, 2023
: Colorectal cancer is a common cancer in both men and women. Colorectal cancer is the third widely diagnosed cancer in the world. The emergence of nanotechnology led the researchers to introduce novel nano-products for cancer diagnosis and treatment ...
Zahra Pouresmaeil, Abdolhassan Doulah, Ali Salehzadeh   +2 more
doaj   +1 more source

Interaction between Bax and Bcl-XL proteins confirmed by partial acceptor photobleaching-based FRET imaging [PDF]

Journal of Innovative Optical Health Sciences, 2020
Exact interaction mechanism between Bax and Bcl-XL, two key Bcl-2 family proteins, is an interesting and controversial issue. Partial acceptor photobleaching-based quantitative fluorescence resonance energy transfer (FRET) measurement, PbFRET, is a ...
Fangfang Yang, Mengyan Du, Xiaoping Wang, Tongsheng Chen   +3 more
doaj   +1 more source

An Autoinhibited Dimeric Form of BAX Regulates the BAX Activation Pathway [PDF]

Molecular Cell, 2016
Pro-apoptotic BAX is a cell fate regulator playing an important role in cellular homeostasis and pathological cell death. BAX is predominantly localized in the cytosol, where it has a quiescent monomer conformation. Following a pro-apoptotic trigger, cytosolic BAX is activated and translocates to the mitochondria to initiate mitochondrial dysfunction ...
Thomas P, Garner, Denis E, Reyna, Amit, Priyadarshi, Hui-Chen, Chen, Sheng, Li, Yang, Wu, Yogesh Tengarai, Ganesan, Vladimir N, Malashkevich, Emily H, Cheng, Evripidis, Gavathiotis   +9 more
openaire   +4 more sources

Reversal of Hyperglycemia and Suppression of Type 1 Diabetes in the NOD Mouse with Apoptotic DNA Immunotherapy™ (ADi™), ADi-100

Biomedicines, 2020
The antigen-specific apoptotic DNA immunotherapeutic, ADi-100, is designed to suppress type 1 diabetes and consists of two DNA plasmids encoding genetic sequences of the apoptosis-inducing molecule, BAX, and the secreted form of the autoantigen, glutamic
David G. Alleva, Melika Rezaee, Linda Yip, Gang Ren, Jarrett Rosenberg, Waldo Concepcion, Alan Escher, Shahrokh Shabahang, Avnesh S. Thakor   +8 more
doaj   +1 more source

Effect of EZH2 Inhibition on Colorectal Cancer Cells: an In Vitro Study [PDF]

Journal of Genetic Resources, 2016
Recently, the epigenetic modifications have been recognized as a regulator of gene expression in various cancers. EZH2 gene is one the most important component of the PRC2 complex. Overexpression of EZH2 was identified in multiple cancers that considered
Farnia Ghafouri Sabzevari, Madjid Momeni-Moghaddam, Faris Farassati, Abolfazl Rad   +3 more
doaj   +1 more source

Pharmacological inhibition of Bax-induced cell death: Bax-inhibiting peptides and small compounds inhibiting Bax [PDF]

Experimental Biology and Medicine, 2019
Bax is an essential mediator of mitochondria-dependent programed cell death. Bax belongs to the Bcl-2 family of proteins and its activities are regulated through interaction with other member proteins in the Bcl-2 family. To date, several apoptosis-inducing drugs activating Bax have been developed, and some of them are already in the market as ...
Kelsey, Jensen, David Jasen, WuWong, Sean, Wong, Mieko, Matsuyama, Shigemi, Matsuyama   +4 more
openaire   +2 more sources

Effects of carfilzomib alone and in combination with cisplatin on the gene expression of Bcl-2 and Bax in ovarian carcinoma cell lines [PDF]

Journal of Preventive and Complementary Medicine
Background: Carfilzomib (CFZ), a proteasome inhibitor, has demonstrated potential in the treatment of ovarian cancer, including variants that are resistant to cisplatin (Cis).Objectives: This study aims to evaluate the effects of CFZ, both as a ...
Alireza Saedi, Javad Zavar Reza, Navid Ghasemzadeh, Moein Moradi, Behnaz Majidi, Amir Hossein Fatehi Marj, Sadegh Zarei   +6 more
doaj   +1 more source

The Induction of Apoptosis by Resveratrol Through Regulatory Effect of miR-21 on the Gene Expression of Bcl2 and Bax in HCT-116 Cells [PDF]

Avicenna Journal of Medical Biochemistry, 2019
Background: Resveratrol (RezV) which is found in several plants including grapes and types of berries has a vital role in inducing apoptosis and suppressing cell proliferation.
Nooshin Shabab, Saeid Afshar, Massoud Saidijam   +2 more
doaj   +1 more source

Effects of melatonin addition to the cold storage medium on cumulus oocyte complex apoptosis, viability and in vitro maturation rates of cat oocytes [PDF]

Kafkas Universitesi Veteriner Fakültesi Dergisi, 2022
Usage of oocytes obtained from ovaries aft er long-term cold storage for in vitro embryo production is a promising tool for the protection of wildlife and endangered animal species. Mammalian oocytes are susceptible to oxidative stress with regard to the
Ramazan ARICI, Kemal AK, Serhat PABUCCUOĞLU, Sema BİRLER, Kamber DEMİR, Selin YAĞCIOĞLU, Ahmet ESER, Nur ERSOY, İdil ORUÇ, Gül BAKIRER ÖZTÜRK, Evrim KÖMÜRCÜ BAYRAK, Bilge ÖZSAİT SELÇUK, Andaç KILIÇKAP, Mithat EVECEN   +13 more
doaj   +1 more source