Pharmacological inhibition of Bax-induced cell death: Bax-inhibiting peptides and small compounds inhibiting Bax [PDF]
Experimental Biology and Medicine, 2019 Bax is an essential mediator of mitochondria-dependent programed cell death. Bax belongs to the Bcl-2 family of proteins and its activities are regulated through interaction with other member proteins in the Bcl-2 family.
Kelsey M. Jensen +4 more
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Journal of Cell Biology, 1999 Here we report that in staurosporine-induced apoptosis of HeLa cells, Bid, a BH3 domain containing protein, translocates from the cytosol to mitochondria.
S. Desagher +8 more
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Association of Bax expression and Bcl2/Bax ratio with clinical and molecular prognostic markers in chronic lymphocytic leukemia [PDF]
Journal of Medical Biochemistry, 2016 Background: In chronic lymphocytic leukemia (CLL), in vivo apoptotic resistance of malignant B lymphocytes results, in part, from the intrinsic defects of their apoptotic machinery.
Vučićević Ksenija +8 more
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Bad, a heterodimeric partner for Bcl-xL and Bcl-2, displaces bax and promotes cell death
Cell, 1995 E. Yang +5 more
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Physiological and pharmacological modulation of BAX.
Trends in Pharmacological Sciences, 2021 Bcl-2-associated X protein (BAX) is a critical executioner of mitochondrial regulated cell death through its lethal activity of permeabilizing the mitochondrial outer membrane (MOM). While the physiological function of BAX ensures tissue homeostasis, dysregulation of BAX leads to aberrant cell death. Despite BAX being a promising therapeutic target for
A. Spitz, E. Gavathiotis
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تأثیر تمرین هوازی با شدت متوسط و زیاد بر بیان ژنهای آپوپتوزی BAX (BCL2 associated X) و BCL2 (B-cell lymphoma 2) میوکارد موش صحرایی پس از کمخونی و خونرسانی مجدد [PDF]
فیزیولوژی ورزشی, 2020 هدف از انجام پژوهش حاضر، تعیین تأثیر تمرین هوازی با شدت متوسط و زیاد بر بیان ژنهای BAX و BCL2 میوکارد موش‌های صحرایی نر پس از کمخونی و خونرسانی مجدد بود. در این پژوهش از 26 سر موش صحرایی ویستار دوماهه با وزن تقریبی 25/25 ± 25/225 گرم استفاده شد.
حامد علی زاده پهلوانی +5 more
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Effects of melatonin addition to the cold storage medium on cumulus oocyte complex apoptosis, viability and in vitro maturation rates of cat oocytes [PDF]
Kafkas Universitesi Veteriner Fakültesi Dergisi, 2022 Usage of oocytes obtained from ovaries aft er long-term cold storage for in vitro embryo production is a promising tool for the protection of wildlife and endangered animal species. Mammalian oocytes are susceptible to oxidative stress with regard to the
Ramazan ARICI +13 more
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DRP1 interacts directly with BAX to induce its activation and apoptosis
EMBO Journal, 2022 The apoptotic executioner protein BAX and the dynamin‐like protein DRP1 co‐localize at mitochondria during apoptosis to mediate mitochondrial permeabilization and fragmentation.
Andreas Jenner +12 more
semanticscholar +1 more source
World Journal of Traditional Chinese Medicine, 2022 Objective: The aim is to investigate the protective effect of andrographolide (AP) on retinal ganglion cells (RGC) in rats with glaucoma and its mechanism.
Jun Li, Jing Lu, Guang Chen, Dan Li
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اثر تمرینات مقاومتی به همراه مصرف عصاره‌ی زعفران بر بیان ژنهای Bax، Bcl-2 و Caspase-3 در بافت هیپوکامپ رت‌های نر آلزایمری القا شده [PDF]
مجله دانشکده پزشکی اصفهان, 2023 مقاله پژوهشیمقدمه: آلزایمر، یک بیماری مخرب با اختلالات پیشرونده است که با کاهش حافظه همراه و عدم وجود درمان قطعی برای آن می‌باشد، هدف از پژوهش حاضر، بررسی اثر تمرینات مقاومتی به همراه مصرف عصاره‌ی زعفران بر بیان ژنهای Bax، Bcl-2 و Caspase-3 در بافت ...
فاضل بازیار +2 more
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