Non-phosphorylatable mutants of Ser184 lead to incomplete activation of Bax
Frontiers in Oncology, 2023 The S184 residue of Bax is the target of several protein kinases regulating cell fate, including AKT. It is well-established that, in cellulo, the substitution of S184 by a non-phosphorylatable residue stimulates both the mitochondrial localization of ...
Lilit Simonyan +10 more
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Armeniacae Semen Regulates Apoptosis and Cell Cycle Progression in MCF-7, MDA-MB-231, and T47D Breast Cancer Cell Lines [PDF]
Middle East Journal of Cancer, 2021 Background: Amygdalin is a glycoside ingredient of rosacea plants that exerts an antitumor effect by blocking the growth of the tumor cells. Therefore, we aimed to use the Armeniacae semen, a member of the Rosacea family, which contains a large amount of
Shiva Mosadegh Manshadi +2 more
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Inhibition of c-Jun N-terminal kinase (JNK) suppresses porcine oocyte ageing in vitro
Czech Journal of Animal Science, 2013 Oocyte ageing is a complex of processes that occur when matured in vitro oocytes are, after reaching the metaphase II stage, exposed to further in vitro culture.
M. Sedmíková +7 more
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Two Targets, One Hit: new Anticancer Therapeutics to Prevent Tumorigenesis Without Cardiotoxicity
Frontiers in Pharmacology, 2021 A serious adverse effect of cancer therapies is cardiovascular toxicity, which significantly limits the widespread use of antineoplastic agents. The promising new field of cardio-oncology offers the identification of potent anti-cancer therapeutics that ...
Zoltán Szabó +4 more
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4 open, 2019 The anti-hyperglycemic drug, Metformin, is effective in treating early stages of diabetes and has been associated with a 37% decrease in cancer incidence. While the precise mechanisms for the anti-cancer effects of Metformin remain to be elucidated, this
Brücher Björn L.D.M., Jamall Ijaz S.
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Apoptosis status and proliferative activity in mucopolysaccharidosis type I mice tongue mucosa cells
Dental Research Journal, 2012 Background: Mucopolysaccharidosis type I (MPS I) is caused by a deficiency of alfa-iduronidase (IDUA), which leads to intralysosomal accumulation of glysosaminoglycans.
Juliana Noguti +5 more
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Radiology and Oncology, 2023 Deregulation of the apoptotic process underlies the pathogenesis of many cancers, including leukemia, but is also very important for the success of chemotherapy treatment.
Pravdic Zlatko +6 more
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Redox Report, 2021 Background Progression of Benign Prostate hyperplasia (BPH) is vulnerable to oxidative stress (OS) and prostatic enlargement among the aging males through apoptosis deregulation.
Nabila Jahan +5 more
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Activation of apoptosis and G0/G1 cell cycle arrest along with inhibition of melanogenesis by humic acid and fulvic acid: BAX/BCL-2 and Tyr genes expression and evaluation of nanomechanical properties in A375 human melanoma cell line [PDF]
Iranian Journal of Basic Medical Sciences, 2022 Objective(s): Humic acid (HA) and Fulvic acid (FA) are major members of humic substances, which are extracted from organic sources including soil and peat.
Mitra Salehi +4 more
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Investigating the mutual effects of autophagy and apoptosis in heart tissue of type 2 diabetic rats in interaction with aerobic exercise training and vitamin D3 injection [PDF]
فیزیولوژی ورزش و فعالیت بدنیBackground and Purpose: The interplay between autophagy and apoptosis is crucial in understanding heart health, particularly in the context of type 2 diabetes.
Hadi Golpasandi +2 more
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