Results 41 to 50 of about 197,763 (291)
Frontiers in Veterinary Science, 2021 Cutaneous papillomaviruses are oncogenic viruses that cause severe, persistent infections that can develop into skin cancers within ultraviolet (UV)-exposed skin of immunodeficient individuals, such as those with X-linked severe combined immunodeficiency
Sarah Quinlan +4 more
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СТРУКТУРНЫЕ ДЕТЕРМИНАНТЫ ВЫТЕСНЕНИЯ БЕЛКА Bax ИЗ КОМПЛЕКСА TOM/Bax БЕЛКОМ tBid ПРИ АПОПТОЗЕ [PDF]
, 2018 Structural factors that induce the proapoptotic activation of Bax by the protein TOM22 of the TOM complex and BH3-only protein tBid are established.
Valery G. Veresov +5 more
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Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Aging and Cancer, EarlyView.Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
Application of cryo-electron microscopy for investigation of Bax-induced pores in apoptosis
Nanotechnology Reviews, 2017 Mitochondrial outer membrane permeabilization (MOMP) is a critical step in apoptosis, the molecular mechanisms of which have been a subject of intensive study.
Kuwana Tomomi
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Mitochondrial targeting of the pro-apoptotic protein Bax : Role of the Bax carboxy-terminal tail. [PDF]
, 2009 Here, I address the function of the carboxy-terminal hydrophobic helix of the pro-apoptotic protein Bax. There has been considerable controversy as to whether this sequence is required for the targeting and insertion of Bax into the mitochondrial outer ...
Brock, Stephanie Erin, 1980-
core +1 more source
Advanced Healthcare Materials, EarlyView.Mitochondria‐targeted nanotherapies emerge as a promising strategy for combating aging‐associated neurodegenerative disorders (NDs) by restoring mitochondrial function, reducing oxidative stress, and improving neuronal survival. Recent advances in nanotechnology, therapeutic delivery, and translational research are highlighted, providing insights into ...
Dnyandev G. Gadhave +8 more
wiley +1 more source
Solo show, Cavalcade, BoLee and Workman, Bruton
Cavalcade is a solo exhibition of new work by artist Olivia Bax. Situated in a former Methodist church, the sculptures respond to the space’s distinctive architecture.
BoLee and Workman, Bax, Olivia
core +3 more sources
Advanced Healthcare Materials, EarlyView.Preparation of RVG‐modified erythrocyte membrane‐coated HMPB nanocarriers loaded with L‐arginine and NBP (RM@HPAN) and its neuroprotective mechanism. After intravenous injection, RM@HPAN achieves prolonged circulation, RVG‐29‐mediated BBB penetration, and ischemic accumulation.
Shaofa Li +9 more
wiley +1 more source
Association of Bax expression and Bcl2/Bax ratio with clinical and molecular prognostic markers in chronic lymphocytic leukemia [PDF]
Journal of Medical Biochemistry, 2016 Background: In chronic lymphocytic leukemia (CLL), in vivo apoptotic resistance of malignant B lymphocytes results, in part, from the intrinsic defects of their apoptotic machinery.
Vučićević Ksenija +8 more
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