Results 121 to 130 of about 198,180 (297)

苯甲酰芍药甙对冠心病模型大鼠心肌细胞凋亡的影响

Zhongguo shiyan zhenduanxue, 2011
目的探讨苯甲酰芍药甙对冠心病模型大鼠心肌细胞凋亡的影响。方法高脂饲料饮食制备冠心病大鼠动物模型,给予苯甲酰芍药甙灌胃治疗4周,采用免疫组化方法检测心肌组织中Bc1-2、Bax的蛋白表达。结果同正常组比较,模型组大鼠Bc1-2显著降低而Bax表达增高 ...
张二力, 李洋, 戈宏焱, 洪英杰, 董宇翔, 许丹, 李有田, 华树成   +7 more
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Self‐Propelled HPB@Lip@AB Nanomotors Ameliorate Dry Eye Disease

Advanced Science, EarlyView.
A self‐propelled HPB@Lip@AB nanomotor system is developed for dry eye disease (DED) therapy, facilitating rapid penetration across ocular surface barriers while integrating hydrogen therapy with multi‐enzyme‐like antioxidant activity. The nanoplatform restores mitochondrial function, suppresses oxidative stress, inflammation, and apoptosis, and ...
Jing Li, Xi Wan, Xinru Su, Zechuan Li, Yue Wang, Ying Wang, Ruofei Li, Huangzhao Wei, Jianbin Zhang, Shuai Wang   +9 more
wiley   +1 more source

维生素A缺乏干眼病角膜组织上皮细胞Fas、FasL、Bax和bcl-2的表达与细胞凋亡的关系研究

Zhongguo shiyan zhenduanxue, 2017
目的探究维生素A缺乏干眼病角膜组织上皮细胞Fas、FasL、Bax和bcl-2的表达与细胞凋亡的关系,为干眼病发病机制的研究提供理论依据。方法 5只雄兔维生素A缺乏干眼病模型以及5只正常喂养的雄兔,分别设为观察组与对照组。采用原位末端标记及免疫组织化学方法检测两组试验动物角膜组织上皮细胞的细胞凋亡情况,并检测FasL、Fas、Bax以及bcl-2等相关基因蛋白在角膜上皮细胞中的表达,探讨维生素A缺乏干眼病角膜组织上皮细胞Fas、FasL、Bax和bcl-2的表达与细胞凋亡的关系 ...
丛越, 王万梅
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Fumarate Hydratase Lactylation Exacerbates Traumatic Brain Injury Pathology via Mitochondrial Dysfunction and Neuroinflammation

Advanced Science, EarlyView.
Tian et al. reveal that FH K112 lactylation is elevated after TBI, leading to fumarate accumulation, mitochondrial damage, mtDNA release and amplified neuroinflammation. AARS2 and SIRT3 act as the “writer” and “eraser” for FH K112 lactylation. The peptide Pep‐K112 targeting this site alleviates brain injury, highlighting a potential therapeutic target.
Yang Tian, Shuoyao Ma, Bo Yang, Fei Gao, Hao Guo, Haixiao Liu, Xun Wu, Wenxing Cui, Jingyu Dong, Qian Lin, Yufeng Ge, Jin Ma, Jiazhen Zhao, Yongzhi Zhang, Dongzhi Xue, Jiaxin Tian, Ziwen Zhang, Kai Wang, Meng Xu, Dayun Feng, Jinpeng Zhou, Yan Qu   +21 more
wiley   +1 more source

Involment of p53, Bax, and Bcl-2 Pathway in Microcystins-Induced Apoptosis in Rat Testis

, 2011
It has been reported that microcystins (MCs) could accumulate in the gonads of mammals and MCs exposure exerts obvious toxic effects on male reproductive system of mammals.
xieping@ihb.ac.cn, Hao, Le, Xie, P, Chinese Acad Sci, Donghu Expt Stn Lake Ecosyst, State Key Lab Freshwater Ecol & Biotechnol China, Inst Hydrobiol, Donghu South Rd 7, Wuhan 430072, Peoples R China, Li, Guang-Yu, Xiong, Qian, Li, Hui-Ying, Qiu, Tong, Xie, Ping   +7 more
core  

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source

Parkin promotes proteasomal degradation of misregulated BAX

, 2017
The pro-apoptotic BCL-2 protein BAX commits human cells to apoptosis by permeabilizing the outer mitochondrial membrane. BAX activation has been suggested to require the separation of helix α5 from α6 and thus the ‘latch’ from the ‘core’ domain among ...
Martin van der Laan, Laan, Martin van der, Edlich, Frank, Atsushi Tanaka, Kathrin Funk, Ralf M. Zerbes, Lauterwasser, Joachim, Aline Oelgeklaus, Oelgeklaus, Aline, Joachim Lauterwasser, Frank Edlich, Cakir, Zeynep, Zeynep Cakir, Fimm-Todt, Franziska, Franziska Todt, Funk, Kathrin, Zerbes, Ralf M., Tanaka, Atsushi   +17 more
core   +1 more source

Mitochondria‐Targeted Nanotherapeutics: A Promising Strategy in Modulating Mitochondrial Function, Transfer, and Transplantation

Advanced Science, EarlyView.
This review summarizes the pathogenic role of mitochondria in diseases and highlights mitochondrial transfer and transplantation as emerging therapeutic strategies. It systematically discusses how nanomaterials are engineered to facilitate these processes, and critically examines the current challenges and future perspectives for their clinical ...
Yuanyuan Su, Zhiyan Gong, Jiao Mu, Lili Huang, Pengfei Yang, Chenli Zhang, Lingshan Zhao, Liling Yang, Jun Deng, Xiaohui Liao   +9 more
wiley   +1 more source

Lactylation‐Driven PROS1‐TYRO3‐CARF Signaling Promotes Therapy‐Induced Senescence Escape and Radioresistance in Meningioma

Advanced Science, EarlyView.
A glycolysis‐driven epigenetic switch promotes therapy resistance in meningioma. Increased lactate production enhances histone H3K27 lactylation, which activates PROS1 secretion. Secreted PROS1 engages TYRO3 signaling to degrade the senescence regulator CARF, allowing cancer cells to escape growth arrest.
Zhuohang Wang, Qixiang Zhang, Keman Liao, Xiaoyu Liu, Hongchi Zhang, Yunsheng Chen, Yuxiao Ma, Yikui Liu, Aoqian Xu, Yuhao Sun, Jiayi Chen, Liuguan Bian, Baofeng Wang   +12 more
wiley   +1 more source

Molecular and Anticancer Effects of β-Carotene on the Apoptotic Pathway via Regulation of Bax/Bcl-2 in MCF-7 Breast Cancer Cell Line [PDF]

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām
Introduction:  Breast cancer stands out as the top cancer type and a major reason for cancer deaths in women around the world. New studies point to β-carotene having possible healing impacts on this cancer.
Amineh Majidi, Saeid Ghorbian, Neda Roshanravan   +2 more
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