Results 51 to 60 of about 221,308 (340)
Movement of Bax from the Cytosol to Mitochondria during Apoptosis
Journal of Cell Biology, 1997 Bax, a member of the Bcl-2 protein family, accelerates apoptosis by an unknown mechanism. Bax has been recently reported to be an integral membrane protein associated with organelles or bound to organelles by Bcl-2 or a soluble protein found in the ...
K. Wolter +5 more
semanticscholar +1 more source
Chemical composition and cytotoxic properties of Clinacanthus nutans root extracts
Pharmaceutical Biology, 2017 Context: Clinacanthus nutans Lindau (Acanthaceae) is a medicinal plant that has been reported to have anti-inflammatory, antiviral, antimicrobial and antivenom activities.
Peik Lin Teoh +6 more
doaj +1 more source
Inhibition of c-Jun N-terminal kinase (JNK) suppresses porcine oocyte ageing in vitro
Czech Journal of Animal Science, 2013 Oocyte ageing is a complex of processes that occur when matured in vitro oocytes are, after reaching the metaphase II stage, exposed to further in vitro culture.
M. Sedmíková +7 more
doaj +1 more source
Biphasic translocation of Bax to mitochondria [PDF]
Biochemical Journal, 2002 Using green fluorescent protein-tagged Bax, we demonstrate that Bax is sequestered from the cytosol of cardiomyocytes in two distinct phases following the induction of apoptosis with staurosporine. In the first phase, lasting several hours, Bax removal from the cytosol was relatively small.
Michela Capano, Martin Crompton
openaire +3 more sources
Bax directly induces release of cytochrome c from isolated mitochondria.
Proceedings of the National Academy of Sciences of the United States of America, 1998 Bax is a pro-apoptotic member of the Bcl-2 protein family that resides in the outer mitochondrial membrane. It is controversial whether Bax promotes cell death directly through its putative function as a channel protein versus indirectly by inhibiting ...
J. Jürgensmeier +5 more
semanticscholar +1 more source
Allosteric sensitization of proapoptotic BAX [PDF]
Nature Chemical Biology, 2017 BCL-2-associated X protein (BAX) is a critical apoptotic regulator that can be transformed from a cytosolic monomer into a lethal mitochondrial oligomer, yet drug strategies to modulate it are underdeveloped due to longstanding difficulties in conducting screens on this aggregation-prone protein.
Pritz, Jonathan R. +10 more
openaire +4 more sources
Effect of EZH2 Inhibition on Colorectal Cancer Cells: an In Vitro Study [PDF]
Journal of Genetic Resources, 2016 Recently, the epigenetic modifications have been recognized as a regulator of gene expression in various cancers. EZH2 gene is one the most important component of the PRC2 complex. Overexpression of EZH2 was identified in multiple cancers that considered
Farnia Ghafouri Sabzevari +3 more
doaj +1 more source
VDAC2 enables BAX to mediate apoptosis and limit tumor development
Nature Communications, 2018 Intrinsic apoptosis is critical to prevent tumor formation and is engaged by many anti-cancer agents to eliminate tumor cells. BAX and BAK, the two essential mediators of apoptosis, are thought to be regulated through similar mechanisms and act ...
H. S. Chin +26 more
semanticscholar +1 more source
Genes & Development, 2016 In this study, O'Neill et al. used genome editing to generate cells deficient for all eight proapoptotic BH3-only proteins (OctaKO) and cells that lack the entire Bcl-2 family (Bcl-2 allKO).
Katelyn L. O’Neill +4 more
semanticscholar +1 more source
Cumulative exposure to solar ultraviolet A & B increases apoptosis of peripheral blood cutaneous lymphocyte antigen (CLA)+ T-Lymphocytes in outdoor workers [PDF]
JDVI (Journal of General Procedural Dermatology & Venereology Indonesia), 2018 Background: Exposure to ultraviolet A & B (UVA-UVB) plays a role in the survival of human life, but it may cause negative effects, such as immunosuppression and skin cancer.
Afif Nurul Hidayati +3 more
doaj +1 more source