Eriodictyol corrects functional recovery and myelin loss in SCI rats
Translational Neuroscience, 2020 This study investigated the therapeutic potential of eriodictyol (EDC) in spinal cord injury (SCI) rats and also the mechanism involved.
Li Chenggang, Wang Chunfang
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Small inhibitor of Bcl-2, HA14-1, selectively enhanced the apoptotic effect of cisplatin by modulating Bcl-2 family members in MDA-MB-231 breast cancer cells [PDF]
, 2010 Inhibition or downregulation of Bcl-2 represents a new therapeutic approach to by-pass chemoresistance in cancer cells. Therefore, we explored the potential of this approach in breast cancer cells.
A Letai +34 more
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Examination of the apelin signaling pathway in acetaminophen-induced hepatotoxicity in rats
Türk Biyokimya DergisiThe present study identifies the level changes of markers (Apelin, Elabela, Meteorin, ALT, AST, GGT) in the liver after acute intake of high-dose paracetamol and their role in determining liver damage.
Dolanbay Turgut +4 more
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Evaluating the effects of hypoxia and taper on expression of Pulmonary Bax and Bcl2 apoptotic proteins [PDF]
Journal of Advanced Biomedical Sciences, 2018 Background & Objective: Due to The limitation of research literature, related to the effect of exercise training with different intensity, Along with Hypoxia Stress on Pulmonary Apoptosis, The purpose of this study was to investigate the effects of ...
Mehdi Yadegari +5 more
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Inhibition of USP7 activity selectively eliminates senescent cells in part via restoration of p53 activity. [PDF]
, 2020 The accumulation of senescent cells (SnCs) is a causal factor of various age-related diseases as well as some of the side effects of chemotherapy. Pharmacological elimination of SnCs (senolysis) has the potential to be developed into novel therapeutic ...
Budamagunta, Vivekananda +9 more
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Zhongguo shiyan zhenduanxue, 2012 目的通过建立小鼠原位肝癌模型,给予化癥散积颗粒灌胃,探讨其对小鼠原位肝癌Bcl-2/Bax表达的影响。方法将H22瘤株直接注射到肝脏的方法建立小鼠原位肝癌模型;分组:模型组、阳性对照组、化癥散积颗粒高、中、低剂量组;采用TUNEL染色法检测凋亡细胞;RT-PCR和Western-Blot分别检测肿瘤组织Bcl-2和Bax mRNA和蛋白表达差异。结果 阳性对照组（又称斑蝥组）和中、高剂量组中药可以诱导肝癌细胞发生凋亡;可以显著增加肿瘤组织中Bax ...
金学洙 +4 more
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Novel insights into the synergistic interaction of Bortezomib and TRAIL: tBid provides the link [PDF]
, 2011 The proteasome inhibitor Bortezomib has been identified as a potent enhancer of TRAIL-induced apoptosis in several human cancers. However, the identification of the underlying molecular mechanisms of this synergistic cell death induction has been ongoing
Fulda, Simone
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Elucidating the mechanism of anti-apoptotic activity of α-crystallin and its therapeutic potential [PDF]
Journal of Stress Physiology & Biochemistryα- Crystallins are the structural proteins of the eye lens which possess anti-apoptotic activity. Both αA- and αB- crystallins are distinct antiapoptotic regulators which can interact with Bax and Bcl-XS, proapoptotic members of the Bcl-2 family in order
Aparajita Chakraborty +2 more
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Heat-shock pretreatment inhibits sorbitol-induced apoptosis in K562, U937 and HeLa cells. [PDF]
, 2009 The aim of this study was to determine whether heat-shock pretreatment exerted a protective effect against sorbitol-induced apoptotic cell death in K562, U937 and HeLa cell lines and whether such protection was associated with a decreased cytochrome c
Aventaggiato, Michele +8 more
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Zhongguo shiyan zhenduanxue, 2007 目的观察凋亡基因Bcl-2、Bax在糖尿病大鼠脑缺血再灌注海马CA1区神经元损伤中的表达。方法采用链脲佐菌素（STZ）诱导和线栓法制备糖尿病大脑中动脉闭塞模型（MCAO）,应用HE染色和免疫组化方法比较糖尿病脑缺血再灌注组与缺血再灌注组海马CA1区神经元缺失、凋亡基因Bcl-2、Bax的表达。结果糖尿病脑缺血再灌注组海马CA1区神经元缺失,明显高于缺血再灌注组 ...
张季声 +7 more
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