Results 221 to 230 of about 154,626 (299)

Functional Polymer‐Engineered Magnetic Nanoparticles as Dual‐Modal Theragnostic Probes for Early Alzheimer's Disease Detection and Therapy

Advanced NanoBiomed Research, EarlyView.
The nanoparticle consists of a 3 nm iron oxide core functionalized with an amphiphilic polymer coating containing Aβ‐targeting DSA moieties and biocompatible PEG chains. This design supports measurable transport in a BBB‐related model and specific interaction with Aβ species, while providing MRI contrast enhancement for diagnosis and therapeutic ...
Ao Shen, Liwen Zhang, Helen Forgham, Jiayuan Zhu, Xumin Huang, Changkui Fu, Ibrahim Javed, Thomas P. Davis, Ruirui Qiao   +8 more
wiley   +1 more source

Mechanism-Driven Design of Metal-Phenolic Networks: From Precision Assembly to Multidimensional Synergistic Therapy for Brain Diseases. [PDF]

Pharmaceutics
Ni M, Hu B, Zhu D, Li B, Jia Y, Lu Y, Wang Y.   +6 more
europepmc   +1 more source

Engineering mRNA-LNP Medicines for the Ageing Brain: Opportunities and Challenges for Neurodegenerative Diseases. [PDF]

Exploration (Beijing)
Belaidi AA, Furtado DL, Alves F, Nisbet RM, Ayton S, Bush AI.   +5 more
europepmc   +1 more source

Neurovascular Unit Dysfunction and Neural Barrier Pathology in Dysautonomia: Molecular Links to Cardiovascular Autonomic Failure. [PDF]

Int J Mol Sci
Kordas B, Zglejc-Waszak K, Mizia P, Matuszewski W, Skowrońska A, Majewski M, Juranek JK.   +6 more
europepmc   +1 more source

Editorial: Advancements in translational stroke research: spotlight on the blood-brain barrier. [PDF]

Front Pharmacol
Chen H, Iweka CA, Yang Y, Hermann DM.
europepmc   +1 more source

Spectroscopic and In Silico Determination of the Structural and Antioxidant Properties of Essential Oils From Lavandula Species Cultivated in the Silivri Region of Istanbul

Journal of the American Oil Chemists' Society, EarlyView.
ABSTRACT Plants are important sources of bioactive compounds that contribute to nutrition, health maintenance, and disease prevention. In this study, the chemical composition and antioxidant potential of essential oils obtained from Lavandula angustifolia “Sevtopolis” and Lavandula × intermedia cultivated in the Silivri region of Istanbul were ...
Bilge Bicak, Beray Kizilkaya, Serda Kecel Gunduz, Aliye Demet Demirag, Sabriye Percin Ozkorucuklu   +4 more
wiley   +1 more source

Construction and Applicability Scenarios of 3D Neurovascular Unit Models In Vitro. [PDF]

Biomolecules
Yu B, Shao Z, Ni Z, Gao Y, Ding Z, Jiang W, Li L, Chu L.   +7 more
europepmc   +1 more source

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

Shared neuropathological features of mild traumatic brain injury and anesthesia. [PDF]

Front Neurol
Shanks A, Pan M, Letterio E, Kolady R, Bazarian JJ.   +4 more
europepmc   +1 more source

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source