Results 1 to 10 of about 608,970 (315)

Large spread in interannual variance of atmospheric CO2 concentration across CMIP6 Earth System Models

npj Climate and Atmospheric Science, 2023
Numerical Earth System Models (ESMs) are our best tool to predict the evolution of atmospheric CO2 concentration and its effect on Global temperature.
Verónica Martín-Gómez, Yohan Ruprich-Robert, Etienne Tourigny, Raffaele Bernardello, Pablo Ortega, Markus G. Donat, Margarida Samsó Cabré   +6 more
doaj   +1 more source

Human α-synuclein aggregation activates ferroptosis leading to parvalbumin interneuron degeneration and motor learning impairment

Communications Biology
The accumulation of α-synuclein induces neuronal loss in midbrain nuclei and leads to the disruption of motor circuits, while the pathology of α-synuclein in cortical regions remains elusive.
Borui Zhang, Kai Chen, Yelin Dai, Xi Luo, Ziwei Xiong, Weijia Zhang, Xiaodan Huang, Kwok-Fai So, Li Zhang   +8 more
doaj   +1 more source

Treadmill exercise prevents stress-induced anxiety-like behaviors via enhancing the excitatory input from the primary motor cortex to the thalamocortical circuit

Nature Communications
Physical exercise effectively prevents anxiety disorders caused by environmental stress. The neural circuitry mechanism, however, remains incomplete. Here, we identified a previously unrecognized pathway originating from the primary motor cortex (M1) to ...
Zhihua Luo, Junlin Chen, Yuchu Liu, Yelin Dai, Hui Gao, Borui Zhang, Haibin Ou, Kwok-Fai So, Ji-an Wei, Li Zhang   +9 more
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Small Molecule Cocktail DLC79 Suppresses Gliomagenesis by Activating Ascl1 and Remodeling Transcriptome

Cells
Glioblastoma (GBM) remains incurable due to its invasive growth and therapeutic resistance. While the neurogenic transcription factor-mediated reprogramming of glioma cells has been reported, pharmacological reprogramming offers a promising alternative ...
Chuxiao Mao, Zhancheng Deng, Zhuming Chen, Lirong Huang, Caiyun Wang, Gong Chen, Qingsong Wang   +6 more
doaj   +1 more source

Effects of tACS-Like Electrical Stimulation on Correlated Firing of Retinal Ganglion Cells: Part III

Eye and Brain, 2022
Franklin R Amthor, Christianne E Strang Department of Psychology, The University of Alabama at Birmingham, Birmingham, AL, 35294, USACorrespondence: Franklin R AmthorDepartment of Psychology, The University of Alabama at Birmingham, 1300 University Blvd,
Amthor FR, Strang CE
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Intrathecal or Intraventricular Tigecycline Therapy for Central Nervous System Infection Associated with Carbapenem-Resistant Klebsiella pneumoniae

Infection and Drug Resistance, 2022
Ning Du,1 En-Qiang Mao,2 Zhi-Tao Yang,2 Hong-Ping Qu,3 Xian Qian,4 Ying Shi,5 Xiao-Lan Bian,6 Juan He,6,* Er-Zhen Chen2,* 1National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of
Du N, Mao EQ, Yang ZT, Qu HP, Qian X, Shi Y, Bian XL, He J, Chen EZ   +8 more
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Uncovering actionable trade-offs of antifungal resistance in a yeast pathogen

Molecular Systems Biology
The increasing prevalence of antifungal resistance represents a major clinical challenge. To explore potential new therapeutic avenues, we investigated fitness trade-offs associated with azole and echinocandin resistance in Nakaseomyces glabratus (syn ...
Juan Carlos Nunez-Rodriguez, Miquel Àngel Schikora-Tamarit, Toni Gabaldón   +2 more
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Lymphatic drainage of the brain in extreme arterial hypertension

Бюллетень сибирской медицины, 2010
In the experiment on rabbits were presents, that experimental arterial hypertension didn’t led to functional failure of lymphatic drainage of brain. On the background of beta-blocker obzidan use failure liquor outflow from brain took place.
Ya. M. Pesin, Yu. I. Borodin, A. A. Beiseembayev, N. K. Omorov   +3 more
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A single-cell transcriptomic dataset profiling traumatic brain injury and NeuroD1-based gene therapy in mice

Scientific Data
Traumatic brain injury (TBI), a leading cause of death and disability globally, often results in functional impairments due to complex pathological mechanisms and limited therapeutic options.
Rongjie Chen, Shuo Zhang, Shanggong Liu, Feng Liao, Ying Sun, Yi Chen, Jiaqi Liang, Jiangyue Liu, Gong Chen, Wenliang Lei   +9 more
doaj   +1 more source

Effects of tACS-Like Electrical Stimulation on Off- and On-Off Center Retinal Ganglion Cells: Part II

Eye and Brain, 2022
Christianne E Strang, Franklin R Amthor Department of Psychology, The University of Alabama at Birmingham, Birmingham, AL, 35294-1170, USACorrespondence: Franklin R AmthorDepartment of Psychology, The University of Alabama at Birmingham, Birmingham, AL ...
Strang CE, Amthor FR
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