Results 161 to 170 of about 116,763 (266)

Lysophosphatidic Acid Reduces Ischemic Brain Injury by Attenuating Vascular Permeability Through LPA4 Receptor Signaling. [PDF]

Transl Stroke Res
Yamada S, Takara K, Hosoe N, Shimizu A, Hayashi Y, Lynda L, Sonoda T, Kikuta K, Kidoya H.   +8 more
europepmc   +1 more source

Hippocampal network activity changes during early epileptogenesis predict subsequent epilepsy

Epilepsia, EarlyView.
Abstract Objective Despite decades of research, the circuit mechanisms that underlie focal epileptogenesis remain incompletely understood. In this study, we aimed to characterize the changes in hippocampal network activity induced by an epileptogenic insult.
Michael Strüber, Tristan Manfred Stöber, Vanessa Schütz, Lara Costard, Valentin Neubert, Sebastian Bauer, Parsa Gharavi, Julika Pitsch, Nico Melzer, Adam Strzelczyk, Jochen Triesch, Kai Siebenbrodt, Felix Rosenow, Ricardo Kienitz   +13 more
wiley   +1 more source

Ultrasound-Enhanced Drug Delivery in Pediatric Neuro-Oncology: A New Therapeutic Strategy. [PDF]

Pharmaceutics
Weber E, Smith CA, Hawkins C, Tabori U, Dirks PB, Rutka JT.   +5 more
europepmc   +1 more source

Gut‐microbiota‐brain Axis and post‐traumatic epilepsy

Epilepsia Open, EarlyView.
Abstract There has been growing evidence that perturbations in gut‐microbiota‐brain axis (GMBA) are involved in mechanisms of chronic sequelae of traumatic brain injury (TBI). This review discusses the connection between GMBA and post‐traumatic epilepsy (PTE), the latter being a common outcome of TBI.
Andrey Mazarati
wiley   +1 more source

Prediction of blood-brain barrier-penetrating peptides using B3BPFN. [PDF]

Front Mol Biosci
Liu X, Zhao Z, Guan J, Wu J, Chen M, Guo Y, Xie P, Chiang YC.   +7 more
europepmc   +1 more source

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

Mural cells protect the adult brain from hemorrhage but do not control the blood-brain barrier in developing zebrafish. [PDF]

Elife
Baltaci OF, Usseglio Gaudi A, Dudczig S, Wang W, Paterson S, Rondon-Galeano MC, Lim YW, Rae J, Lagendijk A, Parton RG, Farley A, Hogan BM.   +11 more
europepmc   +1 more source

Intestinal microbiome alterations in pediatric epilepsy: Implications for seizures and therapeutic approaches

Epilepsia Open, EarlyView.
Abstract The intestinal microbiome plays a pivotal role in maintaining host health through its involvement in gastrointestinal, immune, and central nervous system (CNS) functions. Recent evidence underscores the bidirectional communication between the microbiota, the gut, and the brain and the impact of this axis on neurological diseases, including ...
Teresa Ravizza, Greta Volpedo, Antonella Riva, Pasquale Striano, Annamaria Vezzani   +4 more
wiley   +1 more source

Core Blood-Brain Barrier Disruption in Patients With Large Vessel Occlusion. [PDF]

Stroke
Leigh R, Valyraki N, Wang NY, Abomulay M, Ter Schiphorst A, Valls Carbó A, Hernández-Pérez M, Charbonneau F, Arquizan C, Wacongne A, Sablot D, Costalat V, Ozsancak C, Cohen C, Pasi M, Boulouis G, Yuen N, Desilles JP, Albers GW, Olivot JM, Seners P.   +20 more
europepmc   +1 more source

The gut microbiome and drug‐resistant epilepsy: Microbiome–antiseizure medication interactions and implications for pharmacoresistance

Epilepsia Open, EarlyView.
Abstract Drug‐resistant epilepsy (DRE) affects approximately one‐third of patients with epilepsy and represents a major unmet clinical need. While traditional hypotheses of pharmacoresistance have focused on alterations in drug targets, efflux transporter overexpression, and intrinsic disease severity, the gut microbiome has recently emerged as a ...
Khaled Zammar, Majd A. AbuAlrob, Musab Ali, Simona Lattanzi, Boulenouar Mesraoua   +4 more
wiley   +1 more source