Results 111 to 120 of about 154,626 (299)

PAMPA-BBB assay results.

, 2013
A linear correlation between experimental and reported permeability of selected commercial drugs using the experimental conditions described in the PAMPA-BBB assay methodology was found (10a). The permeability (Pe 10−6 cm s−1) value obtained in the PAMPA-
Valle Palomo (356637), Emanuela Esposito (286778), Carmen Gil (146118), Irene Paterniti (310894), Salvatore Cuzzocrea (37948), Myriam Redondo (356639), Daniel I. Perez (356641), Emanuela Mazzon (37947), Ana Martinez (1313100), Daniela Impellizzeri (310892)   +9 more
core   +1 more source

Targeted β‐Glucan‐Veiled Oral Apremilast Nanotherapy Modulates Key Dysbiosis‐Associated Gut Microbiota and Alleviates Ulcerative Colitis‐Associated Anxiety, Depression, and Neuropsychiatric Behaviors

Advanced Science, EarlyView.
This study introduces β‐glucan‐shielded apremilast laden nanomicelles that withstand gastrointestinal degradation, selectively accumulate in inflamed colon tissue, and modulate the microbiota–gut–brain axis. The formulation restores barrier integrity, reduces systemic and neuroinflammation, and improves anxiety‐ and depression‐like behaviors in colitis
Chandrashekhar Jori, Ahmed Shaney Rehman, Taruna Lamba, Anas Ahmad, Jattin Kumar, Aneesh Ali, Ajesh Joshi, Ashraf Ali, Suhel Parvez, Javed N. Agrewala, Rehan Khan   +10 more
wiley   +1 more source

TITAN-BBB: Predicting BBB Permeability using Multi-Modal Deep-Learning Models

Computational prediction of blood-brain barrier (BBB) permeability has emerged as a vital alternative to traditional experimental assays, which are often resource-intensive and lowthroughput to meet the demands of early-stage drug discovery.
Saeed, Fahad, de Oliveira, Gabriel Bianchin   +1 more
core   +1 more source

Permeability of the BBB.

, 2013
A) Quantification of BBB extravasation of Evans blue (EB) in old mice ...
Jamie N. Mayo (586592), Shawn E. Bearden (586595), Richard S. Beard Jr (586593), Cheng-Hung Chen (586594), Bryce C. Rhodehouse (586591)   +4 more
core   +1 more source

HD‐tDCS Restores Perivascular AQP4 Polarization via PPARγ Modulation to Enhance Glymphatic Clearance After Intracerebral Hemorrhage in Mice

Advanced Science, EarlyView.
HD‐tDCS promotes recovery after intracerebral hemorrhage by enhancing PPARγ‐dependent astrocyte remodeling in a mouse model of ICH. This process suppresses proinflammatory astrocytic activation, restores perivascular AQP4 repolarization, and improves glymphatic influx and efflux, thereby facilitating hematoma and perihematomal edema clearance and ...
Zhiming Li, Yingmei Zhang, Qianqian Tong, Zhitao Gong, Shanyu Zhang, Zhen Qian, Hui Zhang, Qian Yao, Qi Li   +8 more
wiley   +1 more source

Cellular and molecular mechanisms of the blood–brain barrier dysfunction in neurodegenerative diseases

Fluids and Barriers of the CNS
Background Maintaining the structural and functional integrity of the blood–brain barrier (BBB) is vital for neuronal equilibrium and optimal brain function.
Tongli Chen, Yan Dai, Chenghao Hu, Zihao Lin, Shengzhe Wang, Jing Yang, Linghui Zeng, Shanshan Li, Weiyun Li   +8 more
doaj   +1 more source

Human blood–brain barrier spheroid models for the evaluation of drugs targeting brain vascular inflammation

Journal of Pharmacological Sciences
The blood–brain barrier (BBB), primarily formed by brain microvascular endothelial cells (BMECs), restricts substance entry into the brain. BBB inflammation, involving barrier dysfunction and immune cell recruitment, contributes to neurological diseases ...
Ayuka Ebisawa, Hanae Morio, Asuka Minasato, Hiromu Watanabe, Furano Kunitomo, Aleksandra Rutkowska, Tomomi Furihata   +6 more
doaj   +1 more source

Reversing Temozolomide Resistance in Glioblastoma Based on Cuproptosis‐Mediated Positive Feedback Loop

Advanced Science, EarlyView.
To effectively reverse TMZ resistance, this work proposes a cuproptosis‐mediated positive feedback loop that integrates mitochondrial dysfunction, ATP depletion, AMPK‐p53 signaling, and glycolytic inhibition, ultimately amplifying cell death. This cuproptosis‐mediated feedback loop simultaneously disrupts multiple resistance pathways in GBM, including ...
Wenjie Feng, Rui Yang, Chang Weng, Chen Li, Wanrui Shi, Yang Chen, Yang Yang, Yi Liu, Pengfei Ge, Hao Zhang   +9 more
wiley   +1 more source

Surgery on $\widetilde{\Bbb{SL}}\times\Bbb{E}^n$-manifolds

, 2004
7 pages, AMS-LaTeX file, To appear in the Canadian Mathematical Bulletin.
Hillman, J. A., Roushon, S. K.
openaire   +2 more sources

Investigating nanoparticle interactions with the human blood-brain barrier in vitro [PDF]

BIO Web of Conferences
Sahin Hakan, Yucel Oguz, Holloway Paul, Yildirim Eren, Emik Serkan, Gurdag Gulten, Tanriverdi Gamze, Senturk Gozde Erkanli   +7 more
doaj   +1 more source