Results 31 to 40 of about 7,899 (183)

Development and In Vitro Evaluation of Linear PEI-Shelled Heparin/Berberine Nanoparticles in Human Osteosarcoma U-2 OS Cells

Molecules, 2018
Berberine (BBR), a natural isoquinoline alkaloid derived from Chinese herbs, exerts many biological effects, including antiviral, antimicrobial, antidiarrhea, anti-inflammatory, and antitumor effects.
Hung-Kun Hsu, Kuang-Hsing Hsu, Ya-Ming Cheng, Hao-Yi Suen, Shu-Fen Peng   +4 more
doaj   +1 more source

Self-nanoemulsifying system improves oral absorption and enhances anti-acute myeloid leukemia activity of berberine

Journal of Nanobiotechnology, 2018
Background Recently, we found that berberine (BBR) exerts anti-acute myeloid leukemia activity, particularly toward high-risk and relapsed/refractory acute myeloid leukemia MV4-11 cells in vitro. However, the poor water solubility and low bioavailability
Jieping Li, Li Yang, Rui Shen, Li Gong, Zhiqiang Tian, Huarong Qiu, Zhe Shi, Lichen Gao, Hongwu Sun, Guangsen Zhang   +9 more
doaj   +1 more source

Berberine Targets AP-2/hTERT, NF-κB/COX-2, HIF-1α/VEGF and Cytochrome-c/Caspase Signaling to Suppress Human Cancer Cell Growth. [PDF]

PLoS ONE, 2013
Berberine (BBR), an isoquinoline derivative alkaloid isolated from Chinese herbs, has a long history of uses for the treatment of multiple diseases, including cancers.
Lingyi Fu, Wangbing Chen, Wei Guo, Jingshu Wang, Yun Tian, Dingbo Shi, Xiaohong Zhang, Huijuan Qiu, Xiangsheng Xiao, Tiebang Kang, Wenlin Huang, Shusen Wang, Wuguo Deng   +12 more
doaj   +1 more source

Berberine a traditional Chinese drug repurposing: Its actions in inflammation-associated ulcerative colitis and cancer therapy

Frontiers in Immunology, 2022
Berberine (BBR), an isoquinoline alkaloid extracted from Coptidis Rhizoma, has a long history of treating dysentery in the clinic. Over the past two decades, the polytrophic, pharmacological, and biochemical properties of BBR have been intensively ...
Cuipeng Zhu, Kaiqi Li, Xiao-Xu Peng, Tong-Jia Yao, Zi-Yu Wang, Ping Hu, Demin Cai, Hao-Yu Liu, Hao-Yu Liu   +8 more
doaj   +1 more source

Berberine regulates glucose metabolism in largemouth bass by modulating intestinal microbiota

Frontiers in Physiology, 2023
This study examined the role of intestinal microbiota in berberine (BBR)-mediated glucose (GLU) metabolism regulation in largemouth bass. Four groups of largemouth bass (133.7 ± 1.43 g) were fed with control diet, BBR (1 g/kg feed) supplemented diet ...
Yun Xia, Yun Xia, Hui-Ci Yang, Hui-Ci Yang, Kai Zhang, Kai Zhang, Jing-Jing Tian, Jing-Jing Tian, Zhi-Fei Li, Zhi-Fei Li, Er-Meng Yu, Er-Meng Yu, Hong-Yan Li, Hong-Yan Li, Wang-Bao Gong, Wang-Bao Gong, Wen-Ping Xie, Wen-Ping Xie, Guang-Jun Wang, Guang-Jun Wang, Jun Xie, Jun Xie   +21 more
doaj   +1 more source

PEG–lipid–PLGA hybrid nanoparticles loaded with berberine–phospholipid complex to facilitate the oral delivery efficiency

Drug Delivery, 2017
The natural product berberine (BBR), present in various plants, arouses great interests because of its numerous pharmacological effects. However, the further development and application of BBR had been hampered by its poor oral bioavailability.
Fei Yu, Mingtao Ao, Xiao Zheng, Nini Li, Junjie Xia, Yang Li, Donghui Li, Zhenqing Hou, Zhongquan Qi, Xiao Dong Chen   +9 more
doaj   +1 more source

Transformation of berberine to its demethylated metabolites by the CYP51 enzyme in the gut microbiota

Journal of Pharmaceutical Analysis, 2021
Berberine (BBR) is an isoquinoline alkaloid extracted from Coptis chinensis that improves diabetes, hyperlipidemia and inflammation. Due to the low oral bioavailability of BBR, its mechanism of action is closely related to the gut microbiota.
Zheng-Wei Zhang, Lin Cong, Ran Peng, Pei Han, Shu-Rong Ma, Li-Bin Pan, Jie Fu, Hang Yu, Yan Wang, Jian-Dong Jiang   +9 more
doaj   +1 more source

Requirement for Ergosterol in Berberine Tolerance Underlies Synergism of Fluconazole and Berberine against Fluconazole-Resistant Candida albicans Isolates

Frontiers in Cellular and Infection Microbiology, 2017
Candida albicans is one of the most common fungal pathogens. Our previous study demonstrated that concomitant use of berberine (BBR) and fluconazole (FLC) showed a synergistic action against FLC-resistant C.
Yi Xu, Hua Quan, Hua Quan, Yan Wang, Hua Zhong, Jun Sun, Jianjiang Xu, Nuan Jia, Yuanying Jiang   +8 more
doaj   +1 more source

HOF‐Stabilized Apple EV Nanocargo in an NIR‐Responsive Hydrogel Enables On‐Demand Therapeutic Modulation for Transdermal Deep‐Joint Osteoarthritis Therapy

Advanced Healthcare Materials, EarlyView.
An NIR‐responsive transdermal hydrogel integrating apple EV nanocargo, berberine, piperine, HOFs, and graphene oxide enables localized osteoarthritis modulation. The platform supports enhanced transdermal delivery together with mild hyperthermia‐associated and redox‐related responses, leading to reduced inflammation and oxidative stress, improved ...
Yu‐Wen Tseng, Pei‐Wei Weng, Hsien‐Tsung Lu, Jiunn‐Horng Kang, Lekha Rethi, Lekshmi Rethi, Yan‐Ting Chen, Hieu Trung Nguyen, Yao‐Tung Tsai, Andrew E.‐Y. Chuang   +9 more
wiley   +1 more source

Behavior of Stone Mastic Asphalt at Low Temperatures

Romanian Journal of Transport Infrastructure
This paper presents a detailed analysis of the influence of bitumen on low-temperature cracking of MAS 16 asphalt mixtures (stone mastic asphalt) used as wearing course on heavily trafficked roads.
Daniela Dermengiu Roxana, Carmen Răcănel, Mihai Dicu   +2 more
doaj   +1 more source