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Heliyon, 2023 In recent years, the scientific community has focused on traditional natural products and their potential therapeutic benefits. Berberine is a plant-derived isoquinoline alkaloid with a variety of biological properties and identified as a promising ...
Soheila Alipour Noghabi +3 more
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Molecular and Crystal Structures of Three Berberine Derivatives
Molecules, 2001 Berberine azide, berberine thiocyanate, and 8-cyano-8H-berberine were prepared from berberine chloride, a quaternary protoberberine alkaloid. The molecular and crystal structures of all compounds are reported and discussed.
Marek Nečas +2 more
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Effects and mechanisms of berberine in diabetes treatment
Acta Pharmaceutica Sinica B, 2012 Berberine from Rhizoma Coptidis is an oral hypoglycemic agent with anti-dyslipidemia and anti-obesity activities. Its metabolic activity of regulating blood glucose and lipids has been widely studied and evidenced in patients and various animal models ...
Weiping Jia, Jun Yin, Jianping Ye
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Evaluation of the Potential Role of Silver Nanoparticles Loaded with Berberine in Improving Anti-Tumor Efficiency [PDF]
Pharmaceutical Sciences, 2022 Background: Cancer is a progressive disease, its incidence and death rates are rapidly increasing globally. Numerous adverse effects are associated with the available interventions. Hence, the current study was undertaken to explore the anticancer effect
Mohamed Othman +6 more
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Frontiers in Pharmacology, 2022 Lysyl hydroxylase-2 (LH2) involves in the hydroxylation of telopeptide lysine residues during collagen deposition. Recent studies indicate that interleukin (IL)-6 generated by the chronic inflammation disease may trigger the LH2 expression to accelerate ...
Yishan Du +9 more
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Pharmaceutical Biology, 2022 Context Berberine has myocardial protective effects.Objectives The protective effects of berberine on heart ischemia–reperfusion (I/R) injury were explored.Materials and methods Human cardiomyocytes were divided into control group, oxygen-glucose ...
Xiaojing Jia, Wei Shao, Suqing Tian
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EXCLI Journal : Experimental and Clinical Sciences, 2022 Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a secreted protein and a critical regulator of low-density lipoprotein-cholesterol (LDL-C) through inducing degradation of the LDL receptor (LDLR) within the hepatocyte lysosome. PCSK9 deficiency significantly improves the survival rate of cardiovascular disease (CVDs) patients.
Sarina Ataei +2 more
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Berberine induces caspase-independent cell death in colon tumor cells through activation of apoptosis-inducing factor. [PDF]
PLoS ONE, 2012 Berberine, an isoquinoline alkaloid derived from plants, is a traditional medicine for treating bacterial diarrhea and intestinal parasite infections. Although berberine has recently been shown to suppress growth of several tumor cell lines, information ...
Lihong Wang +10 more
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Frontiers in Pharmacology, 2023 Berberine is an isoquinoline alkaloid found in plants. It presents a wide range of pharmacological activities, including anti-inflammatory and antioxidant properties, despite a low oral bioavailability.
Tessa Dehau +5 more
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Frontiers in Immunology, 2021 Berberine, which is a traditional Chinese medicine can inhibit tumorigenesis by inducing tumor cell apoptosis. However, the immunoregulatory of effects berberine on T cells remains poorly understood.
Yunhan Ma +12 more
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