Results 1 to 10 of about 39,868 (244)
Pharmaceutics, 2020 We aimed to develop a berberine formulation to enhance the intestinal absorption and plasma concentrations of berberine through the inhibition of P-glycoprotein (P-gp)-mediated efflux and the intestinal metabolism of berberine in rats.
Im-Sook Song
exaly +3 more sources
Heliyon, 2023 In recent years, the scientific community has focused on traditional natural products and their potential therapeutic benefits. Berberine is a plant-derived isoquinoline alkaloid with a variety of biological properties and identified as a promising ...
Soheila Alipour Noghabi +3 more
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Profiling the Complexity of Resistance Factors in Cancer Cells Towards Berberine and Its Derivatives [PDF]
PharmaceuticalsBackground: Berberine, a benzylisoquinoline alkaloid, has been traditionally used in Ayurvedic and Chinese medicine. We examined the resistance mechanisms to berberine in a panel of different cancer cells and focused on understanding its molecular ...
Nadire Özenver +6 more
doaj +2 more sources
Effects and mechanisms of berberine in diabetes treatment
Acta Pharmaceutica Sinica B, 2012 Berberine from Rhizoma Coptidis is an oral hypoglycemic agent with anti-dyslipidemia and anti-obesity activities. Its metabolic activity of regulating blood glucose and lipids has been widely studied and evidenced in patients and various animal models ...
Jun Yin, Jianping Ye
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Protective effects of berberine-loaded chitosan/solid lipid nanoparticles in streptozotocin-induced gestational diabetes mellitus rats [PDF]
Experimental Biology and MedicineBerberine, known as an antioxidant agent, can improve glycemic indices in animal models of diabetes; however, it is clinically limited by poor bioavailability.
Yu Liu, Shaik Althaf Hussain, Hua Yue
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Berberine ameliorates high-fat diet-induced metabolic disorders through promoting gut Akkermansia and modulating bile acid metabolism [PDF]
Chinese MedicineBackground Coptidis Rhizoma, the rhizome of Coptis chinensis Franch., has long been employed in the treatment of diabetes. Its active component, berberine, has been utilized in clinical practice; however, the underlying mechanisms of its protective ...
Wei-jian Hang +5 more
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Evaluation of the Potential Role of Silver Nanoparticles Loaded with Berberine in Improving Anti-Tumor Efficiency [PDF]
Pharmaceutical Sciences, 2022 Background: Cancer is a progressive disease, its incidence and death rates are rapidly increasing globally. Numerous adverse effects are associated with the available interventions. Hence, the current study was undertaken to explore the anticancer effect
Mohamed Othman +6 more
doaj +1 more source
Pharmaceutical Biology, 2022 Context Berberine has myocardial protective effects.Objectives The protective effects of berberine on heart ischemia–reperfusion (I/R) injury were explored.Materials and methods Human cardiomyocytes were divided into control group, oxygen-glucose ...
Xiaojing Jia, Wei Shao, Suqing Tian
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Frontiers in Pharmacology, 2022 Lysyl hydroxylase-2 (LH2) involves in the hydroxylation of telopeptide lysine residues during collagen deposition. Recent studies indicate that interleukin (IL)-6 generated by the chronic inflammation disease may trigger the LH2 expression to accelerate ...
Yishan Du +9 more
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EXCLI Journal : Experimental and Clinical Sciences, 2022 Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a secreted protein and a critical regulator of low-density lipoprotein-cholesterol (LDL-C) through inducing degradation of the LDL receptor (LDLR) within the hepatocyte lysosome. PCSK9 deficiency significantly improves the survival rate of cardiovascular disease (CVDs) patients.
Sarina Ataei +2 more
openaire +3 more sources