Results 11 to 20 of about 39,868 (244)

Berberine induces caspase-independent cell death in colon tumor cells through activation of apoptosis-inducing factor. [PDF]

PLoS ONE, 2012
Berberine, an isoquinoline alkaloid derived from plants, is a traditional medicine for treating bacterial diarrhea and intestinal parasite infections. Although berberine has recently been shown to suppress growth of several tumor cell lines, information ...
Lihong Wang, Liping Liu, Yan Shi, Hanwei Cao, Rupesh Chaturvedi, M Wade Calcutt, Tianhui Hu, Xiubao Ren, Keith T Wilson, D Brent Polk, Fang Yan   +10 more
doaj   +1 more source

Berberine-microbiota interplay: orchestrating gut health through modulation of the gut microbiota and metabolic transformation into bioactive metabolites

Frontiers in Pharmacology, 2023
Berberine is an isoquinoline alkaloid found in plants. It presents a wide range of pharmacological activities, including anti-inflammatory and antioxidant properties, despite a low oral bioavailability.
Tessa Dehau, Marc Cherlet, Siska Croubels, Michiel Van De Vliet, Evy Goossens, Filip Van Immerseel   +5 more
doaj   +1 more source

Berberine Prolongs Mouse Heart Allograft Survival by Activating T Cell Apoptosis via the Mitochondrial Pathway

Frontiers in Immunology, 2021
Berberine, which is a traditional Chinese medicine can inhibit tumorigenesis by inducing tumor cell apoptosis. However, the immunoregulatory of effects berberine on T cells remains poorly understood.
Yunhan Ma, Guoliang Yan, Junjun Guo, Fujun Li, Haiping Zheng, Chenxi Wang, Yingyu Chen, Yuhan Ye, Helong Dai, Helong Dai, Helong Dai, Zhongquan Qi, Guohong Zhuang   +12 more
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Berberine for prevention of dementia associated with diabetes and its comorbidities: A systematic review [PDF]

, 2020
Background A growing number of epidemiological studies indicate that metabolic syndrome (MetS) and its associated features play a key role in the development of certain degenerative brain disorders, including Alzheimer’s disease and vascular dementia ...
Bell, J.D., Bell, J.D., Bligh, S.W.A., Bligh, S.W.A., Katsuno, T., Katsuno, T., Parkinson, J., Parkinson, J., Shinjyo, N., Shinjyo, N.   +9 more
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Redox regulation of the AMP-activated protein kinase. [PDF]

PLoS ONE, 2010
Redox state is a critical determinant of cell function, and any major imbalances can cause severe damage or death.The aim of this study is to determine if AMP-activated protein kinase (AMPK), a cellular energy sensor, is activated by oxidants generated ...
Yingying Han, Qilong Wang, Ping Song, Yi Zhu, Ming-Hui Zou   +4 more
doaj   +1 more source

Pharmacokinetics and Excretion of Berberine and Its Nine Metabolites in Rats

Frontiers in Pharmacology, 2021
Berberine, a well-known alkaloid, has been proved to possess various pharmacological activities. Previous studies demonstrated that berberine could be extensively metabolized and the metabolites also contributed to its therapeutic effects.
Xinchi Feng, Kun Wang, Shijie Cao, Liqin Ding, Feng Qiu, Feng Qiu   +5 more
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Uptake of and Resistance to the Antibiotic Berberine by Individual Dormant, Germinating and Outgrowing Bacillus Spores as Monitored by Laser Tweezers Raman Spectroscopy. [PDF]

PLoS ONE, 2015
Berberine, an alkaloid originally extracted from the plant Coptis chinensis and other herb plants, has been used as a pharmacological substance for many years.
Shiwei Wang, Jing Yu, Milomir Suvira, Peter Setlow, Yong-qing Li   +4 more
doaj   +1 more source

Molecular dynamics investigation of the interaction between Colletotrichum capsici cutinase and berberine suggested a mechanism for reduced enzyme activity.

PLoS ONE, 2021
Berberine is a promising botanical pesticide against fungal plant pathogens. However, whether berberine inhibits the invasion of fungal pathogen across plant surface remains unclear.
Ying Li, Jinqing Wei, Huizhen Yang, Jing Dai, Xizhen Ge   +4 more
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Berberine inhibits breast carcinoma proliferation and metastasis under hypoxic microenvironment involving gut microbiota and endogenous metabolites

Pharmacological Research, 2023
A potential role of berberine, a benzyl isoquinoline alkaloid, in cancer therapy is apparent. Its underlying mechanisms of berberine against breast carcinoma under hypoxia have not been elucidated.
Yanfang Sun, QianQian Zhou, Fangming Chen, Xiaoyan Gao, Linjun Yang, Xiaoyan Jin, Michael Wink, Farukh S. Sharopov, Gautam Sethi   +8 more
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Alternative final steps in berberine biosynthesis in Coptis japonica cell cultures [PDF]

, 1988
In Coptis japonica cell cultures an alternative pathway has been discovered which leads from (S)-tetrahydrocolumbamine via (S)-canadine to berberine. The two enzymes involved have been partially purified.
Galneder, E., Rüffer, Martina, Tabata, M., Wanner, G., Zenk, Meinhart H.   +4 more
core   +1 more source