Frontiers in Pharmacology, 2022 Abnormal lipid metabolism in renal tubular epithelial cells contributes to renal lipid accumulation and disturbed mitochondrial bioenergetics which are important in diabetic kidney disease.
Qingfeng Rong +6 more
doaj +1 more source
Berberine induces autophagic cell death and mitochondrial apoptosis in liver cancer cells: The cellular mechanism [PDF]
, 2010 Extensive studies have revealed that berberine, a small molecule derived from Coptidis rhizoma (Huanglian in Chinese) and many other plants, has strong anti-tumor properties. To better understand berberine-induced cell death and its underlying mechanisms
Meifen Zhu +13 more
core +1 more source
Molecules, 2018 Berberine has many pharmacological effects, such as antidiabetic, antimicrobial, anti-inflammatory, and antioxidant, but the question remains on how its low oral bioavailability has greatly limited its clinical application. As a safer hypoglycemic agent,
Hong-Xin Cui +4 more
doaj +1 more source
Protective effects of berberine on intestinal ischemia and reperfusion injury in rats [PDF]
Archives of Biological Sciences, 2017 This study aims to investigate the potential protective effects of berberine on ischemia and reperfusion (IR) injury in rats. Thirty male rats were randomly divided into three experimental groups as follows: the sham group, the IR group and the ...
Chen Tanzhou, Lv Bin
doaj +1 more source
Berberine: metabolic and cardiovascular effects in preclinical and clinical trials [PDF]
, 2009 Arrigo FG Cicero1, Sibel Ertek21Internal Medicine, Aging and Kidney Diseases Department, Sant’Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy; 2Ufuk University, Medical Faculty, Dr Ridvan Ege Hospital, Department of ...
CICERO, ARRIGO FRANCESCO GIUSEPPE +5 more
core +1 more source
Genetic evidence for inhibition of bacterial division protein FtsZ by berberine. [PDF]
PLoS ONE, 2010 BACKGROUND: Berberine is a plant alkaloid that is widely used as an anti-infective in traditional medicine. Escherichia coli exposed to berberine form filaments, suggesting an antibacterial mechanism that involves inhibition of cell division.
Jaroslaw M Boberek, Jem Stach, Liam Good
doaj +1 more source
Activation of AMP-activated protein kinase is required for berberine-induced reduction of atherosclerosis in mice: the role of uncoupling protein 2. [PDF]
PLoS ONE, 2011 Berberine, a botanical alkaloid purified from Coptidis rhizoma, is reported to activate the AMP-activated protein kinase (AMPK). Whether AMPK is required for the protective effects of berberine in cardiovascular diseases remains unknown.
Qilong Wang +5 more
doaj +1 more source
A preliminary study on the synthetic lethal effect of berberine and olaparib on pancreatic cancer cells and its mechanism [PDF]
E3S Web of Conferences, 2021 Pancreatic cancer is a kind of malignant tumor with high mortality rate. Early operation and late chemoradiotherapy are the treatment criteria, but the prognosis is still poor.
Zhang Chengyong +9 more
doaj +1 more source
Alternative final steps in berberine biosynthesis in Coptis japonica cell cultures [PDF]
, 1988 In Coptis japonica cell cultures an alternative pathway has been discovered which leads from (S)-tetrahydrocolumbamine via (S)-canadine to berberine. The two enzymes involved have been partially purified.
Wanner, G. +4 more
core +1 more source
Berberine Inhibits the Release of Glutamate in Nerve Terminals from Rat Cerebral Cortex. [PDF]
PLoS ONE, 2013 Berberine, an isoquinoline plant alkaloid, protects neurons against neurotoxicity. An excessive release of glutamate is considered to be one of the molecular mechanisms of neuronal damage in several neurological diseases.
Tzu-Yu Lin +4 more
doaj +1 more source