Results 11 to 20 of about 5,446 (116)

Structure of face-centred icosahedral quasicrystals with cluster close packing. [PDF]

Acta Crystallogr A Found Adv
Using higher‐dimensional crystallography, a new 6D structure model is proposed for F‐type icosahedral quasicrystals with cluster close packing.A 6D structure model for face‐centred icosahedral quasicrystals consisting of so‐called pseudo‐Mackay and mini‐Bergman‐type atomic clusters is proposed based on the structure model of the Al69.1Pd22Cr2.1Fe6.8 3 ...
Yamada T, Takakura H, Yamamoto A.
europepmc   +2 more sources

Recent Insights in Multi-Target Drugs in Pharmacology and Medicinal Chemistry. [PDF]

ChemMedChem
This review highlights the rationale behind multitarget drug design as a promising approach to address diseases with complex etiologies. By combining pharmacophore features from different single‐target drugs, multitarget compounds can interact with multiple biological targets simultaneously.
Cemali SH, Poyraz S, Belveren S, Taş S, Tamer MA, Döndaş NY, Döndaş HA, Sansano JM.   +7 more
europepmc   +2 more sources

Dendritic Cell Migration: An Essential Step in Initiating Adaptive Immunity Across Tissues. [PDF]

Immunol Rev
ABSTRACT Immune surveillance of tissues is primarily carried out by dendritic cells (DCs), which act as sentinels for the adaptive immune system. To accomplish this task, DCs migrate from tissues to regional lymph nodes, or from blood‐exposed regions of the spleen to the white pulp, to prime T cell responses. DC migration is a tightly regulated process
Olson EC, Williams A, Eisenbarth SC.
europepmc   +2 more sources

Long non-coding RNAs as key regulators of neurodegenerative protein aggregation. [PDF]

Alzheimers Dement
Abstract The characteristic events in neurodegenerative diseases (NDDs) encompass protein misfolding, aggregation, accumulation, and their related cellular dysfunction, synaptic function loss. While distinct proteins are implicated in the pathological processes of different NDDs, the process of protein misfolding and aggregation remains notably similar
Xu Q, Liu D, Zhu LQ, Su Y, Huang HZ.
europepmc   +2 more sources

Aptamer and DNAzyme Based Colorimetric Biosensors for Pathogen Detection

Angewandte Chemie, Volume 137, Issue 4, January 21, 2025.
Pathogen detection is crucial for preventing and managing health risks. This review consolidates the selection of functional nucleic acids (FNAs) for pathogen detection and the development of cost‐effective, simple diagnostic applications. It focuses on integrating FNAs with gold nanoparticles, polydiacetylenes, protein enzymes, G‐quadruplexes, and ...
Rudi Liu, Jiuxing Li, Bruno J. Salena, Yingfu Li   +3 more
wiley   +2 more sources

Transcriptional Regulation of Microglial Metabolic and Activation States by P2RY12

Glia, Volume 73, Issue 12, Page 2464-2482, December 2025.
Main Points Transcriptionally, P2RY12‐deficient microglia show heightened metabolic activity, iron handling and oxidative stress at baseline. Upon LPS challenge, impaired glutathione antioxidant responses suggest increased vulnerability to ferroptosis. ABSTRACT Microglia are the resident immune cells of the CNS.
Aida Oryza Lopez‐Ortiz, Madison Doceti, JaQuinta Thomas, Abigayle Duffy, Morgan Coburn, Akhabue K. Okojie, Audrey Lee, Elizabeth Aidita Sou, Alban Gaultier, Ukpong B. Eyo   +9 more
wiley   +1 more source

The Significance of Informal Logic for Philosophy

Informal Logic, 2000
Informal logic is a new sub-discipline of philosophy, roughly definable as the philosophy of argument. Contributors have challenged the traditional concept of an argument as a premiss-conclusion complex, in favour of speech-act, functional and dialogical
David Hitchcock
doaj   +1 more source

CRISPR Technology in Disease Management: An Updated Review of Clinical Translation and Therapeutic Potential

Cell Proliferation, Volume 58, Issue 11, November 2025.
CRISPR‐Cas systems offer transformative genome editing capabilities for precise manipulation of cellular genes. This enables two main therapeutic avenues: ex vivo modification of patient cells for re‐transplantation or direct in vivo gene targeting via advanced delivery methods.
Bahareh Farasati Far, Marziyeh Akbari, Mohammad Amin Habibi, Morteza Katavand, Sherko Nasseri   +4 more
wiley   +1 more source

The Thomas-Nolt Dispute: Some Lessons about Induction

Informal Logic, 1999
I resolve an apparently unresolved dispute about how probable uniform experience makes an extrapolation from it, and draw some general lessons about such enumerative induction.
David Hitchcock
doaj   +1 more source

Innovative Wirkstoffe aus der antibakteriellen Forschung im Kampf gegen mikrobielle Resistenzen

Angewandte Chemie, Volume 137, Issue 10, March 3, 2025.
Dieser Artikel gewährt einen Überblick über in den letzten drei Jahrzehnten untersuchte antibakteriellen Wirkstoffe. Aspekte der Herkunft, der zellulären Targetstrukturen, des antibakteriellen Wirkspektrums und dem Nachweis der Wirksamkeit in Tierstudien werden zusammen mit aktuellen Entwicklungen beleuchtet.
Roderich D. Süssmuth, Marcel Kulike‐Koczula, Peng Gao, Simone Kosol   +3 more
wiley   +1 more source