Results 21 to 30 of about 5,522 (115)

CRISPR Technology in Disease Management: An Updated Review of Clinical Translation and Therapeutic Potential

open access: yesCell Proliferation, Volume 58, Issue 11, November 2025.
CRISPR‐Cas systems offer transformative genome editing capabilities for precise manipulation of cellular genes. This enables two main therapeutic avenues: ex vivo modification of patient cells for re‐transplantation or direct in vivo gene targeting via advanced delivery methods.
Bahareh Farasati Far   +4 more
wiley   +1 more source

Innovative Wirkstoffe aus der antibakteriellen Forschung im Kampf gegen mikrobielle Resistenzen

open access: yesAngewandte Chemie, Volume 137, Issue 10, March 3, 2025.
Dieser Artikel gewährt einen Überblick über in den letzten drei Jahrzehnten untersuchte antibakteriellen Wirkstoffe. Aspekte der Herkunft, der zellulären Targetstrukturen, des antibakteriellen Wirkspektrums und dem Nachweis der Wirksamkeit in Tierstudien werden zusammen mit aktuellen Entwicklungen beleuchtet.
Roderich D. Süssmuth   +3 more
wiley   +1 more source

Fighting Antimicrobial Resistance: Innovative Drugs in Antibacterial Research

open access: yesAngewandte Chemie International Edition, Volume 64, Issue 10, March 3, 2025.
This article provides an overview over antibacterial drugs investigated in the past three decades. Aspects of the compound's origins, their cellular targets, the antibacterial spectrum and proof‐of‐concept in animal studies are covered and current trends are highlighted.
Roderich D. Süssmuth   +3 more
wiley   +1 more source

All Roads Lead to Rome: Pathways to Engineering Disease Resistance in Plants

open access: yesAdvanced Science, Volume 12, Issue 5, February 3, 2025.
Crops lost to diseases necessitate a deeper understanding of plant immunity and the development of disease resistance. Here, the arms‐race between plants and pathogens is briefly described, and a comprehensive overview of the current and emerging strategies for engineering disease resistance in plants is provided.
Aziz Ul Ikram   +8 more
wiley   +1 more source

Challenges to the ancient methane seep search strategy: The Bedford Canyon Formation (Middle Jurassic, Santa Ana Mountains, California)

open access: yesSedimentology, Volume 72, Issue 2, Page 688-707, February 2025.
Abstract Carbonates formed by anaerobic oxidation of methane at localized seeps have been recognized in the rock record based on a list of criteria, including anomalous deposition within detrital facies, complex petrofabrics, seep‐endemic macrofauna and 13C‐depleted isotopic signatures.
Russell S. Shapiro, Miquela Ingalls
wiley   +1 more source

The Rationality of Legal Discourse in Habermas's Discourse Theory

open access: yesInformal Logic, 2003
This paper argues that Habermas's conception of the rationality of moral and legal discussions has import for argumentation theorists interested in the rationality of public deliberations in politics and law.
Eveline T. Feteris
doaj   +1 more source

A Searchable Bibliography of Fallacies – 2016

open access: yesInformal Logic, 2016
This bibliography of literature on the fallacies is intended to be a resource for argumentation theorists. It incorporates and sup- plements the material in the bibliography in Hansen and Pinto’s Fallacies: Classical and Contemporary Readings (1995), and
Hans V. Hansen, Cameron Fioret
doaj   +1 more source

Clinical Validity of the Nursing Diagnoses Impaired Gas Exchange (00030) and Ineffective Breathing Pattern (00032) in Post‐COVID‐19 Individuals

open access: yesNursing Forum, Volume 2025, Issue 1, 2025.
Purpose: To examine the clinical construct validity and specific causal validity of the nursing diagnoses of impaired gas exchange (00030) and ineffective breathing pattern (00032) in post‐COVID‐19 individuals. Methods: A correlational and cross‐sectional study was conducted. A total sample of 199 individuals with a previous COVID‐19 diagnosis, aged 18 
Noemí González-Falcón   +6 more
wiley   +1 more source

Local haplotyping reveals insights into the genetic control of flowering time variation in wild and domesticated soybean

open access: yesThe Plant Genome, Volume 17, Issue 4, December 2024.
Abstract The timing of flowering in soybean [Glycine max (L.) Merr.], a key legume crop, is influenced by many factors, including daylight length or photoperiodic sensitivity, that affect crop yield, productivity, and geographical adaptation. Despite its importance, a comprehensive understanding of the local linkage landscape and allelic diversity ...
Shameela Mohamedikbal   +9 more
wiley   +1 more source

Nano‐ and Micro‐Platforms in Therapeutic Proteins Delivery for Cancer Therapy: Materials and Strategies

open access: yesAdvanced Materials, Volume 36, Issue 45, November 7, 2024.
Protein biologics is one of the future trends in oncology treatment, but free proteins and single‐protein treatment show insufficient therapeutic effects. Various nanoparticle and microsphere platforms provide opportunities to overcome their inherent defects and achieve synergetic combination therapies.
Huijie Han, Hélder A. Santos
wiley   +1 more source

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