Results 121 to 130 of about 96,936 (279)

Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges

British Journal of Pharmacology, EarlyView.
This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu, Kaibin Dai, Zhensheng Lin, Mingfang Ye, Minfeng Chen, Xiaobo Li, Dongmei Zhang   +6 more
wiley   +1 more source

Evaluating Encodings for Bivariate Edges in Adjacency Matrices

Computer Graphics Forum, EarlyView.
Abstract We present the first empirical evaluation of techniques for encoding distributions of quantitative edge values within adjacency matrices. In many real‐world networks, edges represent not a single value but a set of measurements. While adjacency matrices preserve structural clarity, their compact cells limit the simultaneous display of multiple
J. Acosta‐Hernández, A. Lex, T. He
wiley   +1 more source

From Vision to Practice: How Sociotechnical Imaginaries Influence Municipal Healthcare Control

Financial Accountability &Management, EarlyView.
ABSTRACT Digital technologies influence social and organizational structures, materializing visions of desirable futures that both authorize and constrain how societies and organizations are organized, and how control is exercised. Drawing on Science and Technology Studies (STS), this paper examines how sociotechnical imaginaries of “modern and ...
Roy‐Ivar Andreassen, Per Ståle Knardal, Hakim Lyngstadås, Charlotte Morland   +3 more
wiley   +1 more source

BCG

Reactions Weekly, 2022
openaire   +1 more source

Hybrid grading systems improve progression risk stratification in non‐invasive papillary urothelial carcinoma and support a histomorphological continuum of disease progression

Histopathology, EarlyView.
Hybrid grading systems significantly improve progression‐risk stratification in non‐invasive papillary urothelial carcinoma compared with the WHO 2004/2016 binary classification, with most benefit achieved by a Hybrid 3‐Tier framework. These findings support the existence of a histomorphological continuum of progression risk within the conventional ...
Jane K Nguyen, Marcello P Toscano, Jianbo Li, Sean R Williamson, Christopher G Przybycin, Chia‐Sui Kao, Jonathan L Myles, Kristýna Pivovarčíková, Marián Švajdler, Marek Brousil, Mohamed Eltemamy, Laura Bukavina, Venkatesh Krishnamurthi, Christopher Weight, Rebecca A Campbell, Nima Almassi, Reza Alaghehbandan   +16 more
wiley   +1 more source

The PPD-specific T-cell clonal response in UK and Malawian subjects following BCG vaccination: a new repertoire evolves over 12 months.

, 2006
Mycobacterium bovis bacille Calmette Guerin vaccination protects against pulmonary tuberculosis in the United Kingdom but not in Malawi. We investigated whether a difference in the clonal T-cell response to BCG vaccination might account for this.
Bennett, Andrea A., Fine, Paul E.M., Weir, Rosemary E., Msiska, Glyn K., Crampin, Amelia C, Beverley, Peter C.L., Gorak-Stolinska, Patricia, Bennett, Andrea R, Fine, Paul EM, Crampin, Amelia C., Ben-Smith, Anne, Dockrell, Hazel M., Floyd, Sian, Msiska, Glyn K, de Lara, Catherine M, Beverley, Peter CL, Lalor, Maeve K., Weir, Rosemary E, Lalor, Maeve K, Dockrell, Hazel M, de Lara, Catherine M., Makamo, Kandakuone   +21 more
core   +1 more source

Linoleic Acid Enhances Murine Natural Killer Cell Function In Vitro but Compromises Mitochondrial Bioenergetic Function During Retroviral Infection

Immunology, EarlyView.
Natural Killer (NK) cells are potent effectors against virus‐infected and tumour cells. During Friend Virus (FV) infection, fatty acid metabolism supports NK‐cell effector functions. Here, we found that NK cells from FV‐infected mice preferentially take up linoleic acid (LA), which reduced proliferation, mitochondrial function, and increased reactive ...
Vaasudevan Sridhar, Simone Schimmer, Tanja Werner, Rachel Giesen, Mohamed Saad, Constantin P. Krempe, Sven W. Meckelmann, Ulf Dittmer, Elisabeth Littwitz‐Salomon   +8 more
wiley   +1 more source

Epigenetic and Metabolic Changes That Drive Trained Immunity in Response to Microbes and Vaccines

Immunology, EarlyView.
This graphical abstract illustrates how microbial products, vaccines and microbial metabolites activate pattern‐recognition receptor signalling, inducing metabolic rewiring and epigenetic remodelling. These changes establish long‐lasting trained immunity through the functional reprogramming of haematopoietic progenitors and innate immune cells, thereby
Desalegn Abebaw, Aytenew Atnaf, Bantayehu Addis Tegegne, Abebe Fenta, Bantegzie Selabat, Temesgen Baylie, Yonatan Kindie, Zigale Hibstu Teffera, Mekuriaw Belayneh, Mohammed Jemal, Adane Adugna   +10 more
wiley   +1 more source

Mixing It Up: Inflation at Risk

Journal of Money, Credit and Banking, EarlyView.
Abstract Understanding how risk factors shape the economic outlook is essential for guiding policy decisions. This paper develops a flexible framework that decomposes distributional risk forecasts of macro‐economic variables into underlying contributions and supports the construction of interpretable risk measures.
MAXIMILIAN SCHRÖDER
wiley   +1 more source

Vaccine Coverage and Vaccination Delays in Children With Chronic Illness: A French Multicentre Point‐Prevalence Survey

Acta Paediatrica, EarlyView.
F. Dubos, C. Santy, J. Toubiana, M. Caseris, J. Gaschignard, A. Morand, P. Minodier, Z. Maakaroun‐Vermesse, E. Launay, M. Lorrot, C. Brehin, I. Hau, E. Jeziorski, A. Tran, A. Agnani, A. Flammang, M. Meurin, M. Lagrée, D. Diallo   +18 more
wiley   +1 more source