Results 21 to 30 of about 57,303 (248)

Anticipated reduction in COVID-19 mortality due to population-wide BCG vaccination: evidence from Germany

open access: yesHuman Vaccines & Immunotherapeutics, 2021
Bacillus Calmette-Guérin (BCG) vaccine is known to have “bystander benefits” in protecting against heterologous infections; interim analysis of the “ACTIVATE” trial shows protection against respiratory infections in the elderly population.
Daniela Marín-Hernández   +2 more
doaj   +1 more source

Safety of BCG vaccination and revaccination in healthcare workers

open access: yesHuman Vaccines & Immunotherapeutics, 2023
BCG vaccination and revaccination are increasingly being considered for the protection of adolescents and adults against tuberculosis and, more broadly, for the off-target protective immunological effects against other infectious and noninfectious ...
Paola Villanueva   +16 more
doaj   +1 more source

Tuberculosis control by novel vaccines development and Indian initiatives

open access: yesMGM Journal of Medical Sciences, 2023
Pulmonary tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) is one of the worst microbial diseases of humankind and an awful societal problem, especially in underdeveloped countries.
Prasanta Kumar Ghosh
doaj   +1 more source

Enhancing Enzyme Activity With Mutation Combinations Guided by Few‐Shot Learning and Causal Inference

open access: yesAngewandte Chemie, EarlyView.
We present an integrated workflow that predicts activity‐enhancing mutation combinations from minimal experimental data. By proposing in vivo unit yield (yield/expression) as a surrogate for kcat/Km through causal inference, and visualizing local activity landscape, it effectively guides product yield improvement. ABSTRACT Designing enzyme sequences to
Lin Guo   +15 more
wiley   +2 more sources

Effectiveness of booster BCG vaccination in preventing Covid-19 infection

open access: yesHuman Vaccines & Immunotherapeutics, 2021
The evidence that BCG (bacille Calmette-Guerin) vaccine may increase the ability of the immune system to fight off pathogens other than tuberculosis has been studied in the past.
lradj Amirlak   +5 more
doaj   +1 more source

Systematic Review and Meta-Analysis of Response Rates in BCG-unresponsive Non–Muscle-Invasive Bladder Cancer: a Consensus Statement From the International Bladder Cancer Group

open access: yesSociété Internationale d’Urologie Journal, 2022
There is a critical need to establish reference response rates following bladder-sparing therapies administered in the setting of bacillus Calmete-Guerin (BCG)-unresponsive non–muscle-invasive bladder cancer (NMIBC).
Kyle M. Rose   +10 more
doaj   +1 more source

Percutaneous BCG enhances innate effector antitumor cytotoxicity during treatment of bladder cancer: a translational clinical trial

open access: yesOncoImmunology, 2019
Background: Intravesical bacillus Calmette-Guérin (BCG) is the gold standard immunologic agent for treating patients with high-grade non-muscle invasive bladder cancer (NMIBC).
Niannian Ji   +12 more
doaj   +1 more source

Risk factors of severe course and fatality in children hospitalized for COVID-19: a two-center cohort study

open access: yesArchives of Medical Science, 2023
Introduction After 3 years of the pandemic, predictors of COVID-19 severity in children are still not completely known. This study was designed to define the high-risk group in hospitalized children.
Lidia Stopyra   +3 more
doaj   +1 more source

BCG Aortitis, a Rare Complication of BCG Therapy

open access: yesEJVES Vascular Forum, 2023
Intravesical Bacillus Calmette-Guerin (BCG) is an effective treatment for in situ bladder carcinomas; however, extravesical BCG infection may occur in remote organs in patients with underlying primary immunodeficiency and is a potentially serious complication in 3-5% of cases.
Joseph Haddad   +4 more
openaire   +3 more sources

The role of BCG in prevention of tuberculosis and the strategies to improve its immunogenicity

open access: yesHealth Promotion & Physical Activity, 2018
Tuberculosis (TB) remains a major public health problem and the main cause of death from the infectious diseases worldwide. Mycobacterium tuberculosis (Mtb), a causative agent of tuberculosis, is the oldest known human pathogen.
Jolanta Mazurek
doaj   +1 more source

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