Results 51 to 60 of about 166,673 (273)

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Secondary Publication: SARS-CoV-2 and Immunological Response

Tokyo Women's Medical University Journal, 2021
Viruses require the host cellular machinery for protein translation and replication. Upon proliferation, virions damage cells and are released from the infected cells before infecting other cells.
Hidehito Kato, Naoko Yanagisawa
doaj   +1 more source

Piezo1 Channel Mediates Mechanically Programmable Drug Delivery to Potentiate Intravesical Chemotherapy

Advanced Science, EarlyView.
This study utilizes programmable mechanical pressure as a therapeutic enhancer to establish a mechano‐chemotherapy strategy. Controlled pressure activates the mechanosensitive ion channel Piezo1 in bladder cancer, triggering a calcium ion cascade that transiently and reversibly amplifies membrane permeability to chemotherapeutics.
Minghai Ma, Xing Li, Minxuan Jing, Zezhong Yang, Jiale He, Jianpeng Li, Xiao Liang, Yunzhong Jiang, Rou Huang, Yuanquan Zhang, Yuanchun Pu, Jiawei Xiu, Yutong Chen, Kaibo Mi, Pu Zhang, Lei Wang, Jinhai Fan   +16 more
wiley   +1 more source

Phenylacetylcarbinol biotransformation by disrupted yeast cells using ultrasonic treatment in conjunction with a dipropylene glycol mediated biphasic emulsion system

Scientific Reports
Biotransformation of a pharmaceutical precursor, phenylacetylcarbinol (PAC), could be achieved by frozen-thawed Candida tropicalis whole cells (FT-WHC).
Rojarej Nunta, Kritsadaporn Porninta, Sumeth Sommanee, Chatchadaporn Mahakuntha, Charin Techapun, Juan Feng, Su Lwin Htike, Julaluk Khemacheewakul, Yuthana Phimolsiripol, Kittisak Jantanasakulwong, Pornchai Rachtanapun, Usa Bostong, Anbarasu Kumar, Noppol Leksawasdi   +13 more
doaj   +1 more source

Rede Brasileira de Pesquisas em Tuberculose (REDE-TB): missão de desenvolvimento científico para eliminar a tuberculose

Revista de Epidemiologia e Controle de Infecção
Justificativa e Objetivos: Desde seu lançamento, a Rede Brasileira de Pesquisas em Tuberculose (REDE-TB) tem contribuído significativamente para a produção científico-tecnológica no Brasil.
Rander Junior Rosa, Ana Beatriz Marques Valença, Letícia Perticarrara Ferezin, Natacha Martins Ribeiro, Paula Daniella de Abreu, Rubia Laine de Paula Andrade, Willie Otávio Bueno Bernardi, Diogo Henrique Mendes da Silva, Aline Aparecida Monroe, Erica Chimara Silva, Vânia Maria Silva Araújo, Anna Cristina Calçada Carvalho, Ethel Leonor Noia Maciel, Ana Paula Junqueira-Kipnis, Jose Roberto Lapa e Silva, Lia Gonçalves Possuelo, Ricardo Alexandre Arcêncio   +16 more
doaj   +1 more source

Ferroptosis Induction by Fenbendazole Combined With Photothermal Therapy Triggers Dual‐Immunotherapy Against Bladder Cancer

Advanced Science, EarlyView.
The novel intravesical delivery system exhibits GSH‐responsive drug release, enabling a synergistic therapeutic strategy that combines ferroptosis, ICD and PTT. ABSTRACT Ferroptosis, a newly recognized form of regulated cell death, has emerged as a promising strategy in cancer therapy.
Xiaojian Xu, Rui Liang, Anguo Zhao, Jun Zhang, Rongkang Li, Yang Liu, Dashi Deng, Qi Zhuang, Lisha Liu, Lei Peng, Miao Li, Xuedong Wei, Yuhua Huang, Shaohua Zhang, Liang Cheng, Jianquan Hou   +15 more
wiley   +1 more source

Analytical Review of Tools Used in Investment Decision in Agriculture [PDF]

Ovidius University Annals: Economic Sciences Series, 2020
In the last decades the analytical review of the decision-making process became a mixture of risk management and human behavior understanding. Mental capabilities, factor complexity and time constraints have created a state of “bounded rationality ...
Maria Girip, Dorin Martin, Denisa Radulescu   +2 more
doaj  

Infrared Emission from the Nearby Cool Core Cluster Abell 2597

, 2007
We observed the brightest central galaxy (BCG) in the nearby (z=0.0821) cool core galaxy cluster Abell 2597 with the IRAC and MIPS instruments on board the Spitzer Space Telescope.
Andres Jordan, Best P. N., Bolzonella M., Christopher P. O’Dea, Duccio Macchetto, G. Mark Voit, James E. Pringle, James E. Rhoads, Laura Ferrarese, Megan Donahue, Patrick Cote, Paul Goudfrooij, Sangeeta Malhotra, Stefi A. Baum, Voit G. M., William B. Sparks   +15 more
core   +1 more source

Maximal use of 0.05% topical isotretinoin in patients with congenital ichthyosis results in low systemic exposure

British Journal of Clinical Pharmacology, EarlyView.
Abstract Congenital ichthyoses (CI) are rare, inherited skin disorders characterized by hyperkeratosis, scaling and fissuring that significantly impair patients' quality of life. Treatment options are limited, with systemic retinoids reserved for severe cases owing to their adverse effect profile.
Holm Schneider, Christopher G. Bunick, Kathrin Hillmann, Thy N. Huynh, Steven Kempers, Nicolai Peschel, Ulrike Blume‐Peytavi, Joyce M. C. Teng, Alan M. Mendelsohn, John Stinson, Lara Wine Lee   +10 more
wiley   +1 more source

Effect of BCG on Respiratory Complications Caused by COVID-19: A Scoping Review

International Journal of General Medicine, 2022
Cristiane Giacomelli da Costa,1,* Mehrsa Jalalizadeh,1,* Reza Yadollahvandmiandoab,1 Keini Buosi,1 Leonardo O Reis1,2 1Department of UroScience, School of Medical Sciences, University of Campinas – UNICAMP, Campinas, São Paulo, Brazil ...
Costa CGD, Jalalizadeh M, Yadollahvandmiandoab R, Buosi K, Reis LO   +4 more
doaj