Results 31 to 40 of about 223,551 (298)

Reconstitution of the anti-apoptotic Bcl-2 protein into lipid membranes and biophysical evidence for its detergent-driven association with the pro-apoptotic Bax protein. [PDF]

PLoS ONE, 2013
The anti-apoptotic B-cell CLL/lymphoma-2 (Bcl-2) protein and its counterpart, the pro-apoptotic Bcl-2-associated X protein (Bax), are key players in the regulation of the mitochondrial pathway of apoptosis. However, how they interact at the mitochondrial
Marcus Wallgren, Martin Lidman, Anders Pedersen, Kristoffer Brännström, B Göran Karlsson, Gerhard Gröbner   +5 more
doaj   +1 more source

BEX1 promotes imatinib-induced apoptosis by binding to and antagonizing BCL-2. [PDF]

PLoS ONE, 2014
An enhanced anti-apoptotic capacity of tumor cells plays an important role in the process of breakpoint cluster region/Abelson tyrosine kinase gene (BCR/ABL)-independent imatinib resistance. We have previously demonstrated that brain expressed X-linked 1
Qian Xiao, Yeting Hu, Yue Liu, Zhanhuai Wang, Haitao Geng, Lifeng Hu, Dengyong Xu, Ke Wang, Lei Zheng, Shu Zheng, Kefeng Ding   +10 more
doaj   +1 more source

Inhibition of USP7 activity selectively eliminates senescent cells in part via restoration of p53 activity. [PDF]

, 2020
The accumulation of senescent cells (SnCs) is a causal factor of various age-related diseases as well as some of the side effects of chemotherapy. Pharmacological elimination of SnCs (senolysis) has the potential to be developed into novel therapeutic ...
Budamagunta, Vivekananda, Campisi, Judith, He, Yonghan, Li, Wen, Lv, Dongwen, Ortiz, Yuma T, Zhang, Xin, Zhang, Xuan, Zheng, Guangrong, Zhou, Daohong   +9 more
core   +1 more source

Relative transcript level of BMP15, BAX and CASP3 with qRT-PCR in vitrified equine immature cumulus-oocytes complexes

Semina: Ciências Agrárias, 2022
Research focused on female gamete vitrification has increased attention to develop a reliable cryopreservation method to preserve immature equine oocytes.
Mauro Flores Polenz, Gabriel Ribas Pereira, Vitor Braga Rissi, Kalyne Bertolin, Paulo Bayard Gonçalves, Geovani Celso Augusto, Sandra Mara Fiala Rechsteiner   +6 more
doaj   +1 more source

Oxidative Stress-Induced Unscheduled CDK1–Cyclin B1 Activity Impairs ER–Mitochondria-Mediated Bioenergetic Metabolism

Cells, 2021
Targeting the activities of endoplasmic reticulum (ER)–mitochondrial-dependent metabolic reprogramming is considered one of the most promising strategies for cancer treatment. Here, we present biochemical subcellular fractionation, coimmunoprecipitation,
Jan-Gowth Chang, Ni Tien, Yi-Chih Chang, Meng-Liang Lin, Shih-Shun Chen   +4 more
doaj   +1 more source

Emodin, an Emerging Mycotoxin, Induces Endoplasmic Reticulum Stress-Related Hepatotoxicity through IRE1α–XBP1 Axis in HepG2 Cells

Toxins, 2023
Emodin, an emerging mycotoxin, is known to be hepatotoxic, but its mechanism remains unclear. We hypothesized that emodin could induce endoplasmic reticulum (ER) stress through the inositol-requiring enzyme 1 alpha (IRE1α)–X-box-binding protein 1 (XBP1 ...
Su Been Park, Gun Hee Cho, Young Eun Park, Hyang Sook Chun   +3 more
doaj   +1 more source

Antiapoptotic herpesvirus Bcl-2 homologs escape caspase-mediated conversion to proapoptotic proteins [PDF]

, 2000
The antiapoptotic Bcl-2 and Bcl-x(L) proteins of mammals are converted into potent proapoptotic factors when they are cleaved by caspases, a family of apoptosis-inducing proteases (E. H.-Y. Cheng, D. G. Kirsch, R. J. Clem, R. Ravi, M. B. Kastan, A. Bedi,
Bellows, D. S., Burns, W. H., Chau, B. N., Hardwick, J. M., Lazebnik, Y., Lee, P.   +5 more
core   +2 more sources

Possible Protective Effects of Lutein against Ciprofloxacin Induced Bone Marrow Toxicity in Rats

Iraqi Journal of Pharmaceutical Sciences, 2021
Ciprofloxacin, which is a second generation of fluoroquinolone and one of the most effective and widely used drugs within fluoroquinolone. Unfamiliar adverse effects of ciprofloxacin such as bone marrow (BM) suppression, thrombocytopenia, anemia ...
Alaa R. Khudhair, Nada N Al-Shawi
doaj   +1 more source

Mcl-1 is a key regulator of the ovarian reserve [PDF]

, 2015
A majority of ovarian follicles are lost to natural death, but the disruption of factors involved in maintenance of the oocyte pool results in a further untimely follicular depletion known as premature ovarian failure.
Chi, M, Greenblatt, E, Jurisicova, A, Kim, K, Moley, K H, Naranian, T, Omari, S, Opferman, J T, Perumalsamy, A L, Waters, M   +9 more
core   +2 more sources

Hyperphosphorylation of BCL-2 family proteins underlies functional resistance to venetoclax in lymphoid malignancies

The Journal of Clinical Investigation, 2023
The B cell leukemia/lymphoma 2 (BCL-2) inhibitor venetoclax is effective in chronic lymphocytic leukemia (CLL); however, resistance may develop over time.
Stephen Jun Fei Chong, Fen Zhu, Olga Dashevsky, Rin Mizuno, Jolin X.H. Lai, Liam Hackett, Christine E. Ryan, Mary C. Collins, J. Bryan Iorgulescu, Romain Guièze, Johany Penailillo, Ruben Carrasco, Yeonjoo C. Hwang, Denise P. Muñoz, Mehdi Bouhaddou, Yaw Chyn Lim, Catherine J. Wu, John N. Allan, Richard R. Furman, Boon Cher Goh, Shazib Pervaiz, Jean-Philippe Coppé, Constantine S. Mitsiades, Matthew S. Davids   +23 more
doaj   +1 more source