Results 1 to 10 of about 134,380 (103)
PRDX1 Influences The Occurrence and Progression of Liver Cancer by Inhibiting Mitochondrial Apoptosis Pathway [PDF]
Cell Journal, 2022 ObjectiveThe aim of this study is to elucidate the role of PRDX1 in hepatocellular carcinoma using hepatomacells.Materials and MethodsIn this experimental study, we elucidated role of PRDX1, using hepatoma cell lines.ResultsPRDX1 was upregulated in ...
Hong-hua Sun +4 more
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Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022 Background Extracellular vesicles (EVs) are a popular treatment candidate for myocardial injury. This work investigated the effects of mesenchymal stem cells (MSCs)–secreted EVs–derived miR‐200b‐3p on cardiomyocyte apoptosis and inflammatory response ...
Jun Wan +6 more
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Archives of Medical Science, 2022 Introduction In this study, we aimed to investigate the role of rs531564 and the underlying signaling pathways. Material and methods Five hundred and twenty-eight spinal cord injury (SCI) patients were genotyped for the analysis of the effect of ...
Zhuang Zhang, Rubo Sui, Dongjian Xia
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Long Non-Coding RNA PNKY Modulates the Development of Choroidal Neovascularization
Frontiers in Cell and Developmental Biology, 2022 Long non-coding RNAs (lncRNAs) have been widely implicated in human diseases. Our aim was to explore the regulatory role of changes in the expression levels of PNKY and its linked signaling networks in mediating stress-induced choroidal ...
Lianjun Shi +14 more
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Electrotaxis of alveolar epithelial cells in direct-current electric fields
Chinese Journal of Traumatology, 2023 Purpose: This study aims to elucidate the electrotaxis response of alveolar epithelial cells (AECs) in direct-current electric fields (EFs), explore the impact of EFs on the cell fate of AECs, and lay the foundation for future exploitation of EFs for the
Chao-Yue Yang +11 more
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Journal of Translational Medicine, 2023 Background Irinotecan (CPT-11) is a classic chemotherapeutic agent that plays an important role in the clinical treatment of metastatic colon cancer and other malignant tumors. We previously designed a series of novel irinotecan derivatives.
Yongqi Li +9 more
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Brain Sciences, 2021 Several studies have documented the role of hyper-activation of extracellular signal-regulated kinases (ERK) in Autism pathogenesis. Alpha-mangostin (AMG) is a phytoconstituents with anti-oxidants, anti-inflammatory, and ERK inhibition properties in many
Aarti Tiwari +7 more
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Virulence, 2021 Thousands of human deaths occur annually due to Japanese encephalitis (JE), caused by Japanese encephalitis virus. During the virus infection of the central nervous system, reactive gliosis, uncontrolled inflammatory response, and neuronal cell death are
Usama Ashraf +5 more
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Expression of the Phosphatase Ppef2 Controls Survival and Function of CD8+ Dendritic Cells
Frontiers in Immunology, 2019 Apoptotic cell death of Dendritic cells (DCs) is critical for immune homeostasis. Although intrinsic mechanisms controlling DC death have not been fully characterized up to now, experimentally enforced inhibition of DC-death causes various autoimmune ...
Markus Zwick +12 more
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Identification of cis-acting elements and splicing factors involved in the regulation of BIM Pre-mRNA splicing. [PDF]
PLoS ONE, 2014 Aberrant changes in the expression of the pro-apoptotic protein, BCL-2-like 11 (BIM), can result in either impaired or excessive apoptosis, which can contribute to tumorigenesis and degenerative disorders, respectively.
Wen Chun Juan, Xavier Roca, S Tiong Ong
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