Results 21 to 30 of about 34,325,732 (253)

Inhibition of miR-9 decreases osteosarcoma cell proliferation

Biomolecules & Biomedicine, 2020
Osteosarcoma (OS) is the most common primary bone tumor that affects adolescents and young adults. Disruption of microRNA (miRNA) regulation is well established in the pathophysiology of different cancers, including OS.
Wu Gang, Wei Tanjun, Huang Yong, Qin Jiajun, Zhang Yi, Hu Hao   +5 more
doaj   +1 more source

Pramanicin analog induces apoptosis in human colon cancer cells: critical roles for Bcl-2, Bim, and p38 MAPK signaling [PDF]

, 2013
Pramanicin (PMC) is an antifungal agent that was previously demonstrated to exhibit antiangiogenic and anticancer properties in a few in vitro studies. We initially screened a number of PMC analogs for their cytotoxic effects on HCT116 human colon cancer
Karslı, Gizem, Isimjan, Tayirjan T., Bodur, Çağrı, Kütük, Özgür, Başağa, Hüveyda, Harrison, Paul, Bodur Cagri, Ozgur Kutuk, Cagri Bodur, Gizem Karsli-Uzunbas, Ozgur Kutuk (282763), Huveyda Basaga (282766), Tayirjan T. Isimjan (282765), Paul Harrison (51644), Isimjan Tayirjan T., Tayirjan T Isimjan, Gizem Karsli-Uzunbas (282764), Paul Harrison, Harrison Paul, Huveyda Basaga, Cagri Bodur (282762), Karsli-Uzunbas Gizem, Kutuk Ozgur, Basaga Huveyda   +23 more
core   +2 more sources

Roles of Bcl-3 in the pathogenesis of murine type 1 diabetes [PDF]

, 2010
OBJECTIVE: It has long been recognized that autoimmunity is often associated with immunodeficiency. The mechanism underlying this paradox is not well understood.
Ruaidhri J. Carmody, Shi-Jun Zheng, Scott Palmer, Palmer, S., Ruan, Q., Chen, Y.H., Carmody, R.J., Youhai H. Chen, Zheng, S.-J., Qingguo Ruan   +9 more
core   +1 more source

BCL-2-regulated apoptosis.

, 2023
(A) The BCL-2-regulated apoptotic pathway involves the following proteins pro-survival BCL-2 proteins, pro-apoptotic BH3-only proteins, and apoptosis effectors BAX/BAK proteins. Lines indicate interactions between molecules. (B) In healthy cells, the pro-
Nathaniel Chien (14636956), Hyun Joo (199982), Jennifer Yi (14636950), Shivarni Patel (14636959), Vivian Kellner (14636953), Jerry Tsai (199995), Zaina Chaban (14636962)   +6 more
core   +1 more source

Forkhead box protein O3 suppresses uveal melanoma development by increasing the expression of Bcl‑2‑like protein 11 and cyclin‑dependent kinase inhibitor 1B

Molecular Medicine Reports, 2017
Forkhead box protein O3 (FoxO3a) is a forkhead box family transcription factor which serves an important role in a number of biological functions, including tumor growth. A previous study indicated that FoxO3a serves a role in insulin like growth factor‑induced growth, migration and invasion of uveal melanoma (UM) cells; however, whether FoxO3a is ...
Yan, Fengxia, Liao, Rifang, Lin, Shaofen, Deng, Xianguo, Little, Peter J, Zheng, Wenhua   +5 more
openaire   +6 more sources

Acetyl-11-Keto-Beta Boswellic Acid (AKBA) Protects Lens Epithelial Cells Against H2O2-Induced Oxidative Injury and Attenuates Cataract Progression by Activating Keap1/Nrf2/HO-1 Signaling

Frontiers in Pharmacology, 2022
Age-related cataract (ARC) is one of the leading blinding eye diseases worldwide. Chronic oxidative stress and the apoptosis of human lens epithelial cells (HLECs) have been suggested to be the mechanism underlying cataract formation.
Tianke Yang, Tianke Yang, Tianke Yang, Tianke Yang, Xiaolei Lin, Xiaolei Lin, Xiaolei Lin, Xiaolei Lin, Hongzhe Li, Hongzhe Li, Hongzhe Li, Hongzhe Li, Xiyue Zhou, Xiyue Zhou, Xiyue Zhou, Xiyue Zhou, Fan Fan, Fan Fan, Fan Fan, Fan Fan, Jianing Yang, Jianing Yang, Jianing Yang, Jianing Yang, Yi Luo, Yi Luo, Yi Luo, Yi Luo, Xin Liu, Xin Liu, Xin Liu, Xin Liu   +31 more
doaj   +1 more source

Integrated System Pharmacology Approaches to Elucidate Multi-Target Mechanism of Solanum surattense against Hepatocellular Carcinoma

Molecules, 2022
Hepatocellular carcinoma (HCC) is one of the most common malignant liver tumors with high mortality. Chronic hepatitis B and C viruses, aflatoxins, and alcohol are among the most common causes of hepatocellular carcinoma.
Hafiz Rameez Khalid, Muhammad Aamir, Sana Tabassum, Youssef Saeed Alghamdi, Ahmad Alzamami, Usman Ali Ashfaq   +5 more
doaj   +1 more source

Role of FOXO3 Activated by HIV-1 Tat in HIV-Associated Neurocognitive Disorder Neuronal Apoptosis

Frontiers in Neuroscience, 2019
There are numerous types of pathological changes in human immunodeficiency virus (HIV)-associated neurocognitive disorder (HAND), including apoptosis of neurons.
Huaqian Dong, Xiang Ye, Li Zhong, Jinhong Xu, Jinhua Qiu, Jun Wang, Yiming Shao, Huiqin Xing   +7 more
doaj   +1 more source

IGF-I protects cortical neurons against ceramide-induced apoptosis via activation of the PI-3K/Akt and ERK pathways; is this protection independent of CREB and Bcl-2?

, 2005
Current understanding of IGF-I-mediated neuroprotection implies the activation of phosphatidylinositol-3-kinase (PI-3K), which leads to the activation of Akt/Protein Kinase B.
Brugg, B., Arbez, N., Willaime-Morawek, S., Mariani, J.   +3 more
core   +1 more source

Bad expression influences time to androgen escape in prostate cancer [PDF]

, 2007
<b>OBJECTIVE</b>: To assess the role of selected downstream Bcl-2 family members (Bad, Bax, Bcl-2 and Bcl-xL) in the development of androgen-independent prostate cancer (AIPC), as androgen-deprivation therapy is the treatment of choice in ...
Teo, K., Traynor, P., Mukherjee, R., Edwards, J., Gemmell, L.   +4 more
core   +1 more source