Results 21 to 30 of about 134,380 (103)

Assessment of the 3-substituted thietane-1,1-dioxide derivative antidepressant effect using rat model of depression induced by reserpine

Research Results in Pharmacology
Introduction: 3-ethoxythietane-1,1-dioxide (3ETD) is a novel molecule that has demonstrated significant antidepressant properties when administered intraperitoneally (i.p.) to mice once or repeatedly.
Irina L. Nikitina, Gulnara G. Gaisina, Elena E. Klen, Lyubov A. Tkachenko   +3 more
doaj   +1 more source

Investigating the Expression Level of CCAT2 and BIM Genes in Colorectal Cancer Patients [PDF]

Journal of Genetic Resources
Colon cancer ranks as the second most common cancer among women and the third among men globally. Research has demonstrated that reduced expression of the Bcl-2-like protein 11 (BIM) gene in various cancers, including colon cancer, lowers cancer cell ...
Alireza Rangin, Fatemeh Jenagh
doaj   +1 more source

C1QBP promotes apoptosis of goat fetal turbinate cells via inhibiting the expression of TRIM5 or TNFSF10

Frontiers in Veterinary Science
BackgroundInfectious ecthyma is a severe and highly contagious disease caused by ORF virus (ORFV). The virus is responsible for significant economic losses in the goat industry and threatens humans.
Qiuyun Li, Zhengding Tang, Hua Xiang, Yixin Dan, Yupeng Ren, Huanrong Zhang, Falong Yang, Jiangjiang Zhu   +7 more
doaj   +1 more source

Clinical Histopathological and Immunohistochemistry of papillomavirus cutaneous lesions in animals in Al Muthanna veterinary hospital/ Iraq [PDF]

Mirror of Research in Veterinary Sciences and Animals, 2018
Papilloma viruses (PVs) are non-enveloped, small, double stranded DNA viruses with circular genomes that replicate intranuclearly in infected cells. Papilloma viruses have high affinity for stratified squamous epithelia of warm blooded animals including ...
Ibrahim Ali Erzuki, Tho Alfiqar Haidar Ali   +1 more
doaj  

The Parkinson's disease gene product DJ-1 modulates miR-221 to promote neuronal survival against oxidative stress

Redox Biology, 2018
DJ-1 is a highly conserved protein that protects neurons against oxidative stress and whose loss of function mutations are linked to recessively inherited Parkinson's disease (PD).
Stephanie E. Oh, Hye-Jin Park, Liqiang He, Catherine Skibiel, Eunsung Junn, M. Maral Mouradian   +5 more
doaj   +1 more source

Sevoflurane suppresses LPS-induced microglia injury by regulating USP11-mediated UHRF1 deubiquitination

Regenerative Therapy
Background: Spinal cord injury (SCI) is a devastating neurological and pathological condition that leads to severe motor, sensory, and autonomic dysfunctions.
Dongzhi Liu, Chengliang Sun, Xiuli Zhang, Shunheng Gao   +3 more
doaj   +1 more source

LAM-003, a new drug for treatment of tyrosine kinase inhibitor–resistant FLT3-ITD–positive AML

Blood Advances, 2019
: Acute myeloid leukemias (AML) harboring a constitutively active internal tandem duplication (ITD) mutation in the FMS-like kinase tyrosine kinase (FLT3) receptor are associated with poor patient prognosis.
Neil Beeharry, Sean Landrette, Sophia Gayle, Marylens Hernandez, Jeff E. Grotzke, Peter R. Young, Paul Beckett, Xuan Zhang, Bing Z. Carter, Michael Andreeff, Stephanie Halene, Tian Xu, Jonathan Rothberg, Henri Lichenstein   +13 more
doaj   +1 more source

Protein interaction networks characterizing the A549 cells Klotho transfected are associated with activated pro-apoptotic Bim and suppressed Wnt/β-catenin signaling pathway

Scientific Reports
Invasive assays and lung tumor-bearing mice models using a human lung adenocarcinoma cell line A549 cells transfected with the Klotho (KL) gene, A549/KL cells, have confirmed that KL suppresses invasive/metastatic potential.
Mitsuo Matsumoto, Naomi Ogawa, Tetsuya Fukuda, Yasuhiko Bando, Toshihide Nishimura, Jitsuo Usuda   +5 more
doaj   +1 more source

Effect of Acupotomy Intervention on Cervicomuscular Apoptosis in Cervical Spondylosis Rabbits

针刺研究, 2014
Objective To observe the effect of acupotomy therapy on cervicomuscular apoptosis and apoptosis regulator Bax protein expression in cervical spondylosis(CS)rabbits so as to investigate its mechanisms underlying improvement of CS.Methods Twenty-four New ...
GUO Chang-qing, LIU Fu-shui, MA Hui-fang, GUO Yan, LIANG Chu-xi   +4 more
doaj  

IL-1β Controls Proliferation, Apoptosis, and Necroptosis Through the PI3K/AKT/Src/NF-κB Pathway in Leukaemic Lymphoblasts

Biomedicines
Background: Chronic inflammation and the development of cancer are closely linked, with components that comprise the tumour microenvironment—including proinflammatory cytokines—exerting essential tumourigenic effects.
Zitlal-Lin Victoria-Avila, Elba Reyes-Maldonado, María Lilia Domínguez-López, Jorge Vela-Ojeda, Aranza Lozada-Ruiz, Omar Rafael Alemán, Ruth Angélica Lezama   +6 more
doaj   +1 more source