Results 11 to 20 of about 134,380 (103)

Docking‐based approach for identification of mutations that disrupt binding between Bcl‐2 and Bax proteins: Inducing apoptosis in cancer cells

Molecular Genetics & Genomic Medicine, 2019
Background Inducing apoptosis in cancer cells is an important step for the successful treatment of cancer patients. Bcl‐2 is an antiapoptotic protein which determines apoptosis by interacting with proapoptotic members of the Bcl‐2 family.
Pawan Kumar Raghav, Rajesh Kumar, Vinod Kumar, Gajendra P. S. Raghava   +3 more
doaj   +1 more source

Progressive neuronal loss and behavioral impairments of transgenic C57BL/6 inbred mice expressing the carboxy terminus of amyloid precursor protein

Neurobiology of Disease, 2006
The β-secretase cleaved Aβ-bearing carboxy-terminal fragments (βCTFs) of amyloid precursor protein (APP) in neural cells have been suggested to be cytotoxic. However, the functional significance of βCTFs in vivo remains elusive.
Kang-Woo Lee, Joo-Young Im, Jin-Sook Song, Si Hyoung Lee, Ho-Jeong Lee, Hye-Yeong Ha, Jae-Young Koh, Byoung Joo Gwag, Sung-Don Yang, Sang-Gi Paik, Pyung-Lim Han   +10 more
doaj   +1 more source

Inhibition of miR-9 decreases osteosarcoma cell proliferation

Biomolecules & Biomedicine, 2020
Osteosarcoma (OS) is the most common primary bone tumor that affects adolescents and young adults. Disruption of microRNA (miRNA) regulation is well established in the pathophysiology of different cancers, including OS.
Wu Gang, Wei Tanjun, Huang Yong, Qin Jiajun, Zhang Yi, Hu Hao   +5 more
doaj   +1 more source

Acetyl-11-Keto-Beta Boswellic Acid (AKBA) Protects Lens Epithelial Cells Against H2O2-Induced Oxidative Injury and Attenuates Cataract Progression by Activating Keap1/Nrf2/HO-1 Signaling

Frontiers in Pharmacology, 2022
Age-related cataract (ARC) is one of the leading blinding eye diseases worldwide. Chronic oxidative stress and the apoptosis of human lens epithelial cells (HLECs) have been suggested to be the mechanism underlying cataract formation.
Tianke Yang, Tianke Yang, Tianke Yang, Tianke Yang, Xiaolei Lin, Xiaolei Lin, Xiaolei Lin, Xiaolei Lin, Hongzhe Li, Hongzhe Li, Hongzhe Li, Hongzhe Li, Xiyue Zhou, Xiyue Zhou, Xiyue Zhou, Xiyue Zhou, Fan Fan, Fan Fan, Fan Fan, Fan Fan, Jianing Yang, Jianing Yang, Jianing Yang, Jianing Yang, Yi Luo, Yi Luo, Yi Luo, Yi Luo, Xin Liu, Xin Liu, Xin Liu, Xin Liu   +31 more
doaj   +1 more source

Integrated System Pharmacology Approaches to Elucidate Multi-Target Mechanism of Solanum surattense against Hepatocellular Carcinoma

Molecules, 2022
Hepatocellular carcinoma (HCC) is one of the most common malignant liver tumors with high mortality. Chronic hepatitis B and C viruses, aflatoxins, and alcohol are among the most common causes of hepatocellular carcinoma.
Hafiz Rameez Khalid, Muhammad Aamir, Sana Tabassum, Youssef Saeed Alghamdi, Ahmad Alzamami, Usman Ali Ashfaq   +5 more
doaj   +1 more source

Role of FOXO3 Activated by HIV-1 Tat in HIV-Associated Neurocognitive Disorder Neuronal Apoptosis

Frontiers in Neuroscience, 2019
There are numerous types of pathological changes in human immunodeficiency virus (HIV)-associated neurocognitive disorder (HAND), including apoptosis of neurons.
Huaqian Dong, Xiang Ye, Li Zhong, Jinhong Xu, Jinhua Qiu, Jun Wang, Yiming Shao, Huiqin Xing   +7 more
doaj   +1 more source

Liraglutide Protects Cardiomyocytes against Isoprenaline-Induced Apoptosis in Experimental Takotsubo Syndrome

Biomedicines
Takotsubo syndrome (TTS) is a stress-induced cardiomyopathy, characterized by an increased concentration of catecholamines, free radicals, and inflammatory cytokines, endothelial dysfunction, and increased apoptotic activity.
Zorislava Bajic, Tanja Sobot, Ljiljana Amidzic, Natasa Vojinovic, Sanja Jovicic, Milica Gajic Bojic, Dragan M. Djuric, Milos P. Stojiljkovic, Sergey Bolevich, Ranko Skrbic   +9 more
doaj   +1 more source

Ivonescimab combined with chemotherapy shows promising efficacy in an ALK fusion-positive lung adenocarcinoma patient with ALK-TKI resistance: a case report

Frontiers in Oncology
This report describes a case of lung adenocarcinoma harboring an echinoderm microtubule-associated protein-like 4–anaplastic lymphoma kinase (EML4–ALK) fusion, high programmed death-ligand 1 (PD-L1) expression, and a Bcl-2-like protein 11 (BIM) deletion ...
Meiyuan Lin, Yuan Gao, Jun Deng
doaj   +1 more source

Therapeutic Effects of Transplanted Exosomes Containing miR-29b to a Rat Model of Alzheimer’s Disease

Frontiers in Neuroscience, 2020
Alzheimer disease (AD) is a complex neurodegenerative disorder with no definite treatment. The expression of miR-29 family is significantly reduced in AD, suggesting a part for the family members in pathogenesis of the disease.
Yavar Jahangard, Hamideh Monfared, Arman Moradi, Meysam Zare, Javad Mirnajafi-Zadeh, Seyed Javad Mowla   +5 more
doaj   +1 more source

Mechanism of Resistance to Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors and a Potential Treatment Strategy

Cells, 2018
Treatment with epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) improves the overall survival of patients with EGFR-mutated non-small-cell lung cancer (NSCLC).
Tatsuya Nagano, Motoko Tachihara, Yoshihiro Nishimura   +2 more
doaj   +1 more source