Results 201 to 210 of about 231,834 (240)

Nano Delivery Strategy Opens Effective Avenues for the Treatment of Colorectal Cancer

Medicine Bulletin, EarlyView.
ABSTRACT Colorectal cancer (CRC) presents significant therapeutic challenges because of chemoresistance, systemic toxicity, and the complexity of the tumor microenvironment (TME). Nanodrug delivery systems (NDDS) have emerged as versatile platforms capable of overcoming these limitations by enhancing tumor accumulation, improving pharmacokinetics, and ...
Qiurong Wei, Yunli Xu, Tianjiao Zhang, Shuyu Xu, Haonan Wang, Yuan Wang, Xinxin Xie, Xiaolong Liang   +7 more
wiley   +1 more source

RETRACTION: Antiapoptotic and Antioxidant Properties of <i>Orthosiphon stamineus</i> Benth (Cat's Whiskers): Intervention in the Bcl-2-Mediated Apoptotic Pathway. [PDF]

Evid Based Complement Alternat Med
And Alternative Medicine EC.
europepmc   +1 more source

Apoptosis regulators of the Bcl-2 family play a key role in chemoresistance of cholangiocarcinoma organoids. [PDF]

Int J Cancer
Mi W, van Tienderen GS, Shi S, Broeders A, Monfils K, Roest HP, van der Laan LJW, Verstegen MMA.   +7 more
europepmc   +1 more source

The BCL-2 protein family: from discovery to drug development. [PDF]

Cell Death Differ
Croce CM, Vaux D, Strasser A, Opferman JT, Czabotar PE, Fesik SW.   +5 more
europepmc   +1 more source

Targeting the WSB2-NOXA axis in cancer cells for enhanced sensitivity to BCL-2 family protein inhibitors. [PDF]

Elife
Jiao D, Chang K, Jin J, Chen Y, Ren M, Zhang Y, Gao K, Xu Y, Wang L, Wang C.   +9 more
europepmc   +1 more source

[Retracted] ABT‑737, a Bcl‑2 family inhibitor, has a synergistic effect with apoptosis by inducing urothelial carcinoma cell necroptosis. [PDF]

Mol Med Rep
Cheng R, Liu X, Wang Z, Tang K.
europepmc   +1 more source

Vitexin induces apoptosis and enhances daunorubicin efficacy in acute leukemia via modulation of the HIF-1α/Bcl-2/caspase-3 pathway. [PDF]

Sci Rep
Jirawatpraphakorn C, Tanyong D, Jaree A, Owattanapanich W.   +3 more
europepmc   +1 more source

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Targeting the Bcl-2

Current Opinion in Oncology, 2009
Members of the Bcl-2 family of proteins are critical components in regulating the intrinsic apoptotic pathway. Bcl-2 protein overexpression is associated with drug resistance and poor clinical outcome in cancer patients. Preclinical and clinical evaluations demonstrate that downregulation of Bcl-2 restores the intrinsic apoptotic pathways with ...
Mehul P, Patel, Aisha, Masood, Priya S, Patel, Asher A, Chanan-Khan   +3 more
openaire   +2 more sources