Results 211 to 220 of about 369,993 (297)

A Polyproline Type II Peptidomimetic Disrupts a Grb2 SH3C Domain Protein–Protein Interaction Implicated in Breast Cancer

ChemBioChem, EarlyView.
Benzoylurea scaffolds accurately mimic the side‐chain vectors of the i, i + 1/2, and i + 3 positions of polyproline type II helices, showing functional activity in the disruption of a protein–protein interaction implicated in breast cancer. Given the essential role of protein–protein interactions (PPIs) in cellular signaling pathways, their selective ...
James Luccarelli, Philip C. Simister, Andrew D. Hamilton, Stephan M. Feller, Sam Thompson   +4 more
wiley   +1 more source

Selective BCL-2 inhibitor triggers STING-dependent antitumor immunity via inducing mtDNA release. [PDF]

J Immunother Cancer
Zhang W, Pan X, Wang L, Li W, Dai X, Zheng M, Guo H, Chen X, Xu Y, Wu H, He Q, Yang B, Ding L.   +12 more
europepmc   +1 more source

First‐order Sobolev spaces, self‐similar energies and energy measures on the Sierpiński carpet

Communications on Pure and Applied Mathematics, EarlyView.
Abstract For any p∈(1,∞)$p \in (1,\infty)$, we construct p$p$‐energies and the corresponding p$p$‐energy measures on the Sierpiński carpet. A salient feature of our Sobolev space is the self‐similarity of energy. An important motivation for the construction of self‐similar energy and energy measures is to determine whether or not the Ahlfors regular ...
Mathav Murugan, Ryosuke Shimizu
wiley   +1 more source

BCL-2 dependence is a favorable predictive marker of response to therapy for chronic lymphocytic leukemia. [PDF]

Mol Cancer
Chong SJF, Lu J, Valentin R, Lehmberg TZ, Eu JQ, Wang J, Zhu F, Kong LR, Fernandes SM, Zhang J, Herbaux C, Goh BC, Brown JR, Niemann CU, Huber W, Zenz T, Davids MS.   +16 more
europepmc   +1 more source

Dynamic expression of lamin B1 during adult neurogenesis in the vertebrate brain

Developmental Dynamics, EarlyView.
Abstract Background In mammals, specific brain regions such as the dentate gyrus (DG) of the hippocampus and the subventricular zone (SVZ) of the lateral ventricles harbor adult neural stem/progenitor cells (ANSPCs) that give rise to new neurons and contribute to structural and functional brain plasticity.
Diana Zhilina, Lizbeth A. Bolaños Castro, Juan Sebastian Eguiguren, Sara Zocher, Anne Karasinsky, Dimitri Widmer, Alexandre Espinós, Victor Borrell, Michael Brand, Kyoko Miura, Oliver Zierau, Maximina H. Yun, Tomohisa Toda   +12 more
wiley   +1 more source

Casticin Inhibits Osteoclastogenesis via NF-κB/BCL-2 Signaling Pathway. [PDF]

J Microbiol Biotechnol
Huang A, Gu Z, Jin J, Nie T.
europepmc   +1 more source

Changes in the Number, Proliferation Rates, and bcl‐2 Protein Immunoexpression of Epithelial and Periductal Cells From Rat Epididymis During Postnatal Development [PDF]

, 1999
R. Ramírez Parrondo, Rocı́o Martı́n, José Jesús Martín Martín, Jose R. Ramı́rez, Ricardo Paniagua, Luis Santamarı́a   +5 more
openalex   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

BCL-2 mutant B7H6-CAR-T cells synergized with venetoclax for treating small cell lung cancer. [PDF]

J Immunother Cancer
Zhang H, Xia L, Xuzhang W, Li Z, Zhang J, Li F, Cheng C, Wang J, Zong X, Yang X, Lu S.   +10 more
europepmc   +1 more source

Dysregulated Fas and Bcl-2 expression leading to enhanced apoptosis in T cells of multiple myeloma patients

, 1995
Massimo Massaia, Paolo Borrione, C Attisano, Paola M. Barral, Eloise Beggiato, Laura Montacchini, Annamaria Bianchi, Mario Boccadoro, Alessandro Pileri   +8 more
openalex   +1 more source