Results 241 to 250 of about 369,993 (297)

Engineered Exosome‐Based Senolytic Therapy Alleviates Stroke by Targeting p21+CD86+ Microglia

Exploration, EarlyView.
We identified a harmful immune cell type, p21+CD86+ microglia, driving post‐stroke inflammation and developed a targeted exosome‐based therapy (Que@micro‐Exo) to eliminate these cells. This innovative treatment reduced inflammation, alleviated brain damage, and improved recovery in stroke models, offering a promising strategy for stroke and other ...
Jialei Yang, Shipo Wu, Miao He
wiley   +1 more source

Exploring the Neuroprotective Role of Selenium: Implications and Perspectives for Central Nervous System Disorders

Exploration, EarlyView.
Selenium (Se) is a crucial element in selenoproteins, key biomolecules for physiological function in vivo. Central nervous system can express all 25 kinds of selenoproteins, which protect neurons by reducing oxidative stress and inflammatory response. Neuroprotection is being investigated through the biological study of Se.
Guanning Huang, Ying Liu, Xiadong Zhu, Lizhen He, Tianfeng Chen   +4 more
wiley   +1 more source

Synergistic Inhibition of Colon Cancer Cell Proliferation via p53, Bax, and Bcl-2 Modulation by Curcumin and Plumbagin Combination. [PDF]

ACS Omega
Ahmad I, Ahmad S, Samad MA, Adam AM, Zughaibi TA, Alhosin M, Shakil S, Khan MS, Alsaieedi AA, Kumer A, Tabrez S.   +10 more
europepmc   +1 more source

Saikosaponin b1 Attenuates Liver Fibrosis by Blocking STAT3/Gli1 Interaction and Inducing Gli1 Degradation

Exploration, EarlyView.
Saikosaponin b1 attenuates liver fibrosis by competitively disrupting the interaction between signal transducer and activator of transcription 3 (STAT3) and glioma‐associated oncogene‐1 (Gli1) in the activated hepatic stellate cells (HSCs). The blocked interaction of STAT3 and Gli1 promotes the degradation of Gli1, inhibits Gli1 transcriptional ...
Meiyu Shao, Xiaoqing Zhang, Jiamei Sun, Hongyan Dong, Xin Han, Qiao Yang, Roufen Chen, Liteng Shen, Lei Xu, Lu Wang, Bo Zhu, Dongxin Tang, Shuosheng Zhang, Keda Lu, Mengyun Peng, Gang Cao   +15 more
wiley   +1 more source

Molecular Profile (Estrogen Receptor, Progesterone Receptor, Bcl-2 and Ki-67) of the Ectopic Endometrium in Patients with Endometriosis. [PDF]

Int J Mol Sci
Coroleucă CA, Coroleucă CB, Coroleucă R, Brătilă PC, Nodiți AR, Roșca I, Brîndușe LA, Brătilă E, Boț M.   +8 more
europepmc   +1 more source

Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation

, 1995
Tadaaki Miyazaki, Zhao‐Jun Liu, Atsuo Kawahara, Yasuhiro Minami, Kyoko Yamada, Yoshihide Tsujimoto, Edward L. Barsoumian, Roger M Perlmutter, Tadatsugu Taniguchi   +8 more
openalex   +1 more source

Black Garlic: Production Process, Bioactive Compounds, and Health Effects

Food Chemistry International, EarlyView.
Black garlic, produced under controlled temperature and humidity, undergoes biochemical transformations that enhance its antioxidant capacity, bioactive compounds, and unique flavor profile. This review highlights its production process, health benefits, and functional food potential based on scientific evidence.
Hatice Kubra Sasmaz, Turkan Uzlasir, Serkan Selli, Hasim Kelebek   +3 more
wiley   +1 more source

Critical Roles of VEGFR1, VEGFR2, VEGFR3, BAX, and BCL-2 in the Pathogenesis of Varicose Veins: Unveiling Molecular Mechanisms. [PDF]

Am J Mens Health
Abedinzadeh M, Nazari A, Vahidi SA, Pourmasumi S, Khorramdelazad H.   +4 more
europepmc   +1 more source

High expression of bcl-2 mRNA as a determinant of poor prognosis in acute myeloid leukemia

, 1998
T. Karakas, Ulrich Maurer, Eckhart Weidmann, C.C. Miething, D. Hoelzer, Lothar Bergmann   +5 more
openalex   +1 more source

Neuroprotective Properties of Wild Mango (Mangifera caloneura Kurz) Leaves on Alleviating Urban Air Pollutant Toxicity: Insights From Transcriptome Analysis of a Human Neuronal Cell Model

Food Frontiers, EarlyView.
ABSTRACT Exposure to urban air pollution, particularly particulate matter (PM), has been correlated with an increased risk of neurodegenerative diseases, notably Alzheimer's and Parkinson's diseases. However, the mechanisms underlying the association between urban air pollution and neurodegenerative diseases remain unclear.
Parinee Kittimongkolsuk, Suporn Sukjamnong, Sakawrat Janpaijit, Panthakarn Rangsinth, Sawarin Chumpolphant, Kamonwan Chaikhong, George Pak‐Heng Leung, Valerie W. Hu, Tewarit Sarachana, Anchalee Prasansuklab, Tewin Tencomnao   +10 more
wiley   +1 more source