Bcl-2-Ome – a database and interactive web service for dissecting the Bcl-2 interactome [PDF]
Cell Death & Differentiation, 2016 published
Hantusch, Annika +3 more
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Bis, a Bcl-2-binding protein that synergizes with Bcl-2 in preventing cell death [PDF]
Oncogene, 1999 Bcl-2 is the best characterized inhibitor of apoptosis, although the molecular basis of this action is not fully understood. Using a protein interaction cloning procedure, we identified a human gene designated as bis (mapped to chromosome 10q25) that encoded a novel Bcl-2-interacting protein. Bis protein showed no significant homology with Bcl-2 family
Jeong-Hwa Lee +5 more
openaire +3 more sources
Leishmania donovani induced increase in macrophage Bcl-2 favors parasite survival
Frontiers in Immunology, 2016 Members of the Bcl-2 family are major regulators of apoptosis in mammalian cells and hence infection-induced perturbations in their expression could result into elimination of the parasites or creation of a niche favoring survival. In this investigation,
Rajeev Kumar Pandey +5 more
doaj +1 more source
Evaluation of Bcl-2 as a marker for chronic kidney disease prediction in cats
Frontiers in Veterinary Science, 2023 Chronic kidney disease (CKD) is a frequent condition in elderly cats. Bcl-2 is linked to kidney disease through the processes of apoptosis and fibrosis.
Pattiya Pila +6 more
doaj +1 more source
Circulating histones as clinical biomarkers in critically ill conditions
FEBS Letters, EarlyView.Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez +17 more
wiley +1 more source
Correlation between Bcl-2 Expression and the Efficacy of Bcl-2 Inhibitors in Patients with Myelodysplastic Syndromes [PDF]
Zhongguo quanke yixueBackground The heterogeneity of myelodysplastic syndromes (MDS) is strong, with poor efficacy of existing therapeutic regimens and large individual differences in patient prognosis. B-cell lymphomato-2 (Bcl-2) protein is highly expressed in patients with
WU Jiafei, WANG Jun, WANG Yijing, ZHENG Boyue, WANG Yu, JIANG Chuanyan, DONG Dandan, LI Hui
doaj +1 more source
Targeting BCL-2 regulated apoptosis in cancer
Open Biology, 2018 The ability of a cell to undergo mitochondrial apoptosis is governed by pro- and anti-apoptotic members of the BCL-2 protein family. The equilibrium of pro- versus anti-apoptotic BCL-2 proteins ensures appropriate regulation of programmed cell death ...
K. Campbell, S. Tait
semanticscholar +1 more source
Variants of bcl-2 specific siRNA for silencing antiapoptotic bcl-2 in pancreatic cancer [PDF]
Gut, 2005 Pancreatic cancer remains a devastating diagnosis with only limited therapeutic options. Specific inhibition of expression of target genes has become possible using small interfering (si) RNAs. We therefore investigated how far siRNA specific for bcl-2 may serve as a therapeutic option for pancreatic cancer in vitro and in vivo.siRNAs targeting two ...
Daniel Neureiter +7 more
openaire +3 more sources
Cyclic nucleotide signaling as a drug target in retinitis pigmentosa
FEBS Letters, EarlyView.Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää +2 more
wiley +1 more source
Bcl-XL but Not Bcl-2 Is a Potential Target in Medulloblastoma Therapy
Pharmaceuticals, 2022 Medulloblastoma (MB) is the most common solid tumour in children and, despite current treatment with a rather aggressive combination therapy, accounts for 10% of all deaths associated with paediatric cancer.
Mike-Andrew Westhoff +10 more
doaj +1 more source